iiinova — where your digital self keeps evolving

Pawel Lorkiewicz @pklork01.bsky.social · 02/06/2025

Really looking forward to reading this paper

Reposted by Pawel Lorkiewicz

Stand Up for Science! @standupforscience.net · 01/06/2025

HAPPY PRIDE 🏳️‍🌈 Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them. Stand with us to protect LGBTQ+ science from political erasure. grant-watch.us/nih-data.html @rcmedphys.bsky.social

A word cloud made from flagged terms in terminated NIH grant proposals. The most prominent words in large font include “trans,” “diverse,” “diversity,” “minority,” “sex,” “expression,” “mental health,” “gender,” and “women.” Other visible terms include “LGBTQ,” “racial,” “underrepresented,” “disability,” “barriers,” “black,” “equity,” “health equity,” “vaccine,” “bias,” and “intersectionality.” The word cloud highlights terms related to identity, inclusion, and marginalized communities.

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Pawel Lorkiewicz @pklork01.bsky.social · 01/06/2025

Really impressed to see applied side of #massspec analysis. Just learned about a forensic assay for ~290 drugs with over 800 transitions - all in a 5 minute chromatographic run. Running on Agilent Technologies 6495D triple quad system with an amazing sensitivity. Pretty impressive stuff. #ASMS2025

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Pawel Lorkiewicz @pklork01.bsky.social · 01/06/2025

Starting my #ASMS2025 adventure with Waters users meeting. The TQ Absolute XR is definitely a highlight (we have the Absolute and we like it a lot; an increase in robustness is definitely a welcome feature). Decent talks. Getting almost too technical at times but I've learned a lot. #TeamMassSpec

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Pawel Lorkiewicz @pklork01.bsky.social · 23/05/2025

#ASMS2025 is just around the corner. This year we will have two presentations (poster and oral) discussing our approach to #LC-MS profiling and analysis of Phase II metabolites in the urine. #teammassspec

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Reposted by Pawel Lorkiewicz

Center for Integrative Environmental Health Sciences (CIEHS) @ciehs.bsky.social · 19/05/2025

We stand with you in this time of loss and recovery. Please consider donating to the Team Kentucky Storm Relief Fund to support those affected: secure.kentucky.gov/formservices... #TeamKentucky #KentuckyStrong

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Pawel Lorkiewicz @pklork01.bsky.social · 08/05/2025

Our latest manuscript describes an #LCMS platform profiling Phase II metabolites. We annotated 424 mercapturates, glucuronides, sulfates linked to over 200 environmental chemicals. This demonstrates ILGA's value for advancing #Exposomics Link doi.org/10.1016/j.en... #MassSpectrometry #Metabolomics

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Reposted by Pawel Lorkiewicz

Marisa Kabas @marisakabas.bsky.social · 03/04/2025

For my latest, I wrote about my HHS RIF tracking doc and why it felt important to cut through the fog of terror to capture the data:

thehandbasket.co

Tracking the HHS April Fools’ Massacre

The Handbasket has created a document to capture the destruction.

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Reposted by Pawel Lorkiewicz

David Broadhurst @davidbroadhurst.bsky.social · 15/11/2024

I created a Metabolomics starter pack. A list of researchers from the wonderful world of #metabolomics. If you would like to be added (or removed) just let me know. go.bsky.app/J3VPYKm

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Pawel Lorkiewicz @pklork01.bsky.social · 03/03/2025

When I began in analytical chemistry, I explored organic and inorganic compounds as matrices for MALDI imaging of lipids in the negative ion mode. MALDI-MS and MS-based lipidomics were so new that my early presentations fell under OTHER → other. Things have changed a lot since then.

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Pawel Lorkiewicz @pklork01.bsky.social · 20/02/2025

That will affect KY universities

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Reposted by Pawel Lorkiewicz

Jonathan Lambert @jonlambert.bsky.social · 18/02/2025

NEW: NSF confirmed that they fired 168 employees today, out of their staff of ~1,500 feds. This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.

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Reposted by Pawel Lorkiewicz

Alex Carll, PhD, MSPH @cardiocarll.bsky.social · 03/02/2025

Taking Omega3s and VitD over three years slowed biological aging by 3-4 months when combined with exercise. @ciehs.bsky.social @uoflenvirome.bsky.social

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Reposted by Pawel Lorkiewicz

Gary Siuzdak @siuzdak.bsky.social · 03/02/2025

“Because they wouldn’t let me give it away” my answer when people ask why did I not publish AMMS with a publishing house. Free PDF at Scripps Research: masspec.scripps.edu/about/mass-s... Royalty-free print version at Amazon ($15.08): a.co/d/8dEWO8a

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Reposted by Pawel Lorkiewicz

Dave Levitan @davelevitan.bsky.social · 31/01/2025

So, *very* unconfirmed, but I've heard from inside a fed agency that there is a chance a significant chunk of gov websites, in particular healthcare and energy-related ones, might just go dark today at 5 pm because it's impossible to scrub the DEI stuff by then.

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Pawel Lorkiewicz @pklork01.bsky.social · 31/01/2025

OK @uoflenvirome.bsky.social 🤩 Thanks for sharing my posts!!! I want to see Bluesky becoming a livelier platform.

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Reposted by Pawel Lorkiewicz

Dave Levitan @davelevitan.bsky.social · 30/01/2025

I’ve heard from people inside NIH, EPA, the National Cancer Institute, the National Parks Service, and more. Signal info is in bio if you are at any federal agency and want to chat.

splinter.com

'Insulted and Confused': Inside Agencies, Federal Employees React to Mass Resignation Offer

Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.

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Pawel Lorkiewicz @pklork01.bsky.social · 29/01/2025

OK, we've seen it before—use glucuronidase & sulfatase, hydrolyze conjugates, release parent chemical (or phase I met) & measure that. Call us crazy, but we thought "What if we just identify and measure all the conjugates instead?".. So we did. papers.ssrn.com/sol3/papers.... #Massspec #metabolomics

papers.ssrn.com

Mapping of Phase Ii Human Urinary Metabolome

Humans are constantly exposed to both natural-occurring and anthropogenic chemicals. Targeted mass spectrometry approaches are frequently used to measure a smal

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Reposted by Pawel Lorkiewicz

mzmine @mzmine.bsky.social · 28/01/2025

New #mzmine release out now! Matching millions of reference spectra against thousands of samples was never faster. Go and test it today. Download: github.com/mzmine/mzmin... youtu.be/AFv55sUn9Lg

youtu.be

New features in mzmine 4.5

YouTube video by mzio GmbH

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Reposted by Pawel Lorkiewicz

Dave Levitan @davelevitan.bsky.social · 28/01/2025

My understanding is that clinical trials should not be interrupted, so hopefully the reports about canceled appointments are done... but it's hard to say. If you are a participant in a clinical trial (or at NIH clinical center) and have seen disruptions, I'd love to hear from you—Signal in bio.

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Reposted by Pawel Lorkiewicz

Dave Levitan @davelevitan.bsky.social · 23/01/2025

I have heard some internal confirmation that NIH study sections are being suspended theoretically under the Federal Advisory Committee Act. Which is insane.

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Pawel Lorkiewicz @pklork01.bsky.social · 21/01/2025

This looks like a very extensive and useful resource. The authors put a lot of work into this manuscript. Can't wait to read it.

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Pawel Lorkiewicz @pklork01.bsky.social · 20/01/2025

Our paper describing a dilute-and-shoot targeted LC-MS/MS method for measuring 35 urinary metabolites of #VOCs and #tobacco alkaloids is now published in Journal of Chromatography B. The article is available here: www.sciencedirect.com/science/arti... #MassSpecRSS #teamMassSpec #LC-MS #exposomics

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Reposted by Pawel Lorkiewicz

The Conversation U.S. @us.theconversation.com · 16/01/2025

Wildfire smoke is now the top source of harmful PM2.5, microscopic particulate matter that can penetrate into the lungs, in the western U.S.. An environmental toxicologist examines the impact: buff.ly/4gPXmbk (Luke Montrose, Colorado State University) 🌎 #climatesky #california #LAfires

buff.ly

LA fires: Long-term exposure to wildfire smoke is poorly understood − and a growing risk

Human bodies aren’t prepared for the toxic chemicals in smoke, and the effects can be harmful in the short term and longterm.

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Pawel Lorkiewicz @pklork01.bsky.social · 13/01/2025

Our paper was accepted for publication in Journal of Chromatography B. Great way to start the week.

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Reposted by Pawel Lorkiewicz

Scott Waldman @scottpwaldman.bsky.social · 03/01/2025

The incoming Trump administration plans to target the National Climate Assessment so that it can't be used to defend regulations in court. Russ Vought, Trump's OMB pick, wants to personally approve a team of climate denialists to rewrite it. www.eenews.net/articles/tru...

eenews.net

Trump team takes aim at crown jewel of US climate research

A top aide to the president-elect wants tighter control over the National Climate Assessment.

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Pawel Lorkiewicz @pklork01.bsky.social · 03/01/2025

Here's a preprint of our manuscript papers.ssrn.com/sol3/papers.... a result of ~2 yr of work on #LC-MS ILGA workflow for comprehensive Phase II #metabolomics analysis. We highlight ILGA's use in #exposomics and elucidate impact of #environmental exposures on health. #MassSpecRSS #MassSpectrometry

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Pawel Lorkiewicz @pklork01.bsky.social · 17/12/2024

This manuscript just came out in JBC I'm glad we got to collaborate with Dr Wysoczynski and Tyler Jobe from his lab. Together with De Silva we provided stable isotope resolved #metabolomics data used in the manuscript. Link: www.sciencedirect.com/science/arti... #teammasspec #envirome

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Pawel Lorkiewicz @pklork01.bsky.social · 11/12/2024

Found out about this DNA adduct database: sites.google.com/umn.edu/dnaa... from a manuscript that came out from Turesky, Villalta et al. - Mass Spectral Library for DNA Adductomics pubs.acs.org/doi/10.1021/... #exposomics #teammasspec #adductomics

sites.google.com

Home

Humans are continuously exposed to hazardous chemicals in the environment and diet, or to endogenously produced electrophiles, all of which can form covalent modifications to DNA (DNA adducts). If not...

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Pawel Lorkiewicz @pklork01.bsky.social · 10/12/2024

From the page: "Wildfire smoke exposure was associated with greater odds of being diagnosed with dementia. The findings suggest that reducing wildfire smoke exposure could potentially reduce the risk of dementia." www.nih.gov/news-events/...

nih.gov

Wildfire smoke exposure and dementia risk

Wildfire smoke exposure was associated with greater odds of being diagnosed with dementia.

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Pawel Lorkiewicz @pklork01.bsky.social · 10/12/2024

Our paper describing a dilute-and-shoot targeted LC-MS/MS method for measuring 35 urinary metabolites of #VOCs and #tobacco alkaloids is currently under review. The article is available as a pre-print here: papers.ssrn.com/sol3/papers.... #exposomics #LCMS #massspec #tobaccoresearch

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