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PhageExe

@phagexe.bsky.social
19 followers 7 following 3 posts

Promoting the University of Exeter's world leading research in translational phage biology

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Meaghan Castledine @mcastd.bsky.social · 10/07/2025
How do macrophages influence the evolution of phage resistance? We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance. Pre-print 👇 www.biorxiv.org/content/10.1...
biorxiv.org
Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance
Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Ev...
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Reposted by PhageExe
Ben Temperton @btemperton.bsky.social · 04/06/2025
At long last, the MHRA have released their much promised guidance document for phage therapeutics in the UK: assets.publishing.service.gov.uk/media/683ed3... Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.
assets.publishing.service.gov.uk
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PhageExe @phagexe.bsky.social · 31/05/2025
If you want to improve promiscuity and yield of Pseudomonas aeruginosa for production of phages, start by taking out its restriction modification system: www.biorxiv.org/content/10.1...
biorxiv.org
Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation
Phage therapy is a promising treatment for multidrug-resistant bacterial infections. Due to their high host specificity, phages must be matched to the target clinical strains. Efficiently identifying ...
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PhageExe @phagexe.bsky.social · 29/04/2025
Remy Chait's super-cool paper on phage lasers is now up on Biorxiv. A beautiful collaboration between modelling and experimental work, driven by passionate curiosity about unusual features Remy observed on some spot assays. www.biorxiv.org/content/10.1...
biorxiv.org
Stable coexistence and transport of lytic phage infections with migrating bacterial hosts
Bacteriophages (phages), viruses that exclusively infect bacterial hosts, are the most abundant living entities across diverse environments, coexisting with their bacterial hosts at densities exceedin...
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PhageExe @phagexe.bsky.social · 07/03/2025
Using CRISPRi to non-invasively manipulate and probe the lifecycle and infectivity of T7. Very cool work from @bergmillerlab.bsky.social . T7 is a tough cookie to control! www.frontiersin.org/journals/mic...
frontiersin.org
Frontiers | Programming CRISPRi to control the lifecycle of bacteriophage T7
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Ben Temperton @btemperton.bsky.social · 05/03/2025
Amazing few days with collaborators at Mowi and PhD student @mrliambh.bsky.social understanding where phage therapeutics could have the greatest impact in salmon farming in Scotland.
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Meaghan Castledine @mcastd.bsky.social · 15/11/2024
Hello new phage phollowers! I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition" www.cell.com/trends/micro...
cell.com
Critically evaluating the relative importance of phage in shaping microbial community composition
The ubiquity of bacteriophages (phages) and the major evolutionary and ecological impacts they can have on their microbial hosts has resulted in phages often cited as key drivers shaping microbial com...
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citizenphage.bsky.social @citizenphage.bsky.social · 27/02/2025
On a day where the National Audit Office reported that the government was not doing enough to combat the threat of untreatable bacterial infections (www.theguardian.com/society/2025...), we met with legislators to highlight the power of phage therapy to provide new treatments to patients.
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The Gold Lab @the-gold-lab.bsky.social · 12/12/2024
Early Christmas present! @mathewmclaren.bsky.social @willstuart.bsky.social @daumlab.bsky.social
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