Reposted by PhageExe
How do macrophages influence the evolution of phage resistance?
We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.
Pre-print 👇
www.biorxiv.org/content/10.1...
biorxiv.org
Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance
Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Ev...