The common antibiotic doxycycline inhibits the ribosome. Here, using cryo-EM, the authors identify additional binding sites for doxycycline in the Coxiella burnetii and E. coli ribosomes.

Antimicrobial resistance is driving the search for new antibiotics and a greater understanding of their mechanism of action. Doxycycline is amongst the most-prescribed antimicrobials. It demonstrates ...

Outnumbering their hosts by at least a factor of 10, viruses are the most common biological entity on Earth, are major drivers of evolution, and greatly impact on the dynamics of our planet's ecosyste...