iiinova — where your digital self keeps evolving

Reposted by Mario R Mestre

Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 18/03/2026

Great start to the CPH MGE Computational Workshop! Awesome organization by @pentamorfico.bsky.social, @leightonpayne.bsky.social, & Dana Rorin, and a great lineup of speakers! @apcamargo.bsky.social kicking things off this morning!

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Reposted by Mario R Mestre

Alvaro Sanchez @asanchezlab.bsky.social · 09/03/2026

New preprint on the limits of detecting higher-order interactions in microbial communities. www.biorxiv.org/content/10.6... We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.

biorxiv.org

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Reposted by Mario R Mestre

Sternberg Lab @sternberglab.bsky.social · 04/03/2026

Out now! In collaboration with Leifu Chang, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems! Links to the published articles: tinyurl.com/55kpavet tinyurl.com/sk6djwx3 Previous thread for the preprint: bsky.app/profile/did:...

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Reposted by Mario R Mestre

Sternberg Lab @sternberglab.bsky.social · 17/10/2025

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

biorxiv.org

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase

Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

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Reposted by Mario R Mestre

RdRp Summit @rdrpsummit.bsky.social · 19/02/2025

The abstract submission & registration for #RdRpSummit2025 is NOW OPEN!!! 🎉🙌 Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal? Consider submitting your research in one of our sessions! More info: RdRp.io

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Seth Shipman @seth-shipman.bsky.social · 30/01/2025

We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: www.biorxiv.org/content/10.1...

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Asimov Press @asimovpress.bsky.social · 29/01/2025

For example, Crick speculated that DNA → protein might be possible but seemed unlikely. He also suggested that RNA → DNA could be feasible, even though there was no evidence for it yet. This turned out to be prophetic.

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Asimov Press @asimovpress.bsky.social · 29/01/2025

Most people misunderstand the Central Dogma. In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification. Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵

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Yunha Hwang @microyunha.bsky.social · 19/11/2024

Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio

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