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Partnership for Clean Competition @pccantidoping.bsky.social · 53m

Don’t miss our latest podcast episode where we talk with Stephen about his career and what it means to him to be an advocate for clean competition in sport. Listen to the full episode here: cleancompetition.org/anti-doping-... #podcast #science #antidoping #sportsentertainment #cleancompetition

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Partnership for Clean Competition @pccantidoping.bsky.social · 21h

This review article examines innovations & advances in microsampling techniques, technologies, sample preparation, and analyses. These include microsampling devices used in anti-doping testing and use of new analytical workflows to detect protein & peptide doping agents. pubs.rsc.org/ay/article/d...

The image shows details about the article linked in the post. It was published in the journal Analytical Methods. The title of the article is, "Microsampling of proteins from biological matrices: sampling methods and devices, typical workflows, clinical examples, novel applications and innovations."

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Partnership for Clean Competition @pccantidoping.bsky.social · 01/10/2026

Authors developed methods to detect the synthetic peptide retatrutide & reported on excretion profiles in plasma & urine. It was only detectable in plasma & had a long detection window (~50 days). This shows plasma is a suitable matrix for retatrutide detection. pmc.ncbi.nlm.nih.gov/articles/PMC...

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Partnership for Clean Competition @pccantidoping.bsky.social · 30/09/2026

We're excited to share findings from Dr. John Eiler's PCC-funded research. He developed an orbitrap-based mass spectrometry method that provides multidimensional isotope fingerprints. The approach could help identify the sources of steroids in anti-doping samples. pubmed.ncbi.nlm.nih.gov/42752109/

The image shows details about the paper linked in the post. It was published in the journal Analytical Chemistry. The title of the article is, "Fragment-Resolved Carbon and Hydrogen Isotope Analysis of Urinary Steroids by Orbitrap Mass Spectrometry."

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Partnership for Clean Competition @pccantidoping.bsky.social · 29/09/2026

Steroids have long been banned in sport, but the risks of using them go beyond sitting out from competition. Dr. Aaron Baggish discussed the long-term consequences of doping and why doing it with medical supervision doesn’t necessarily make it safer. cleancompetition.org/anti-doping-podcast/181

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Partnership for Clean Competition @pccantidoping.bsky.social · 25/09/2026

Researchers developed & validated methods to detect testosterone & its metabolites using supercritical fluid chromatography that expedite separation & evaporation steps. Results using the new method were comparable to those obtained via common HPLC-based procedures. pubmed.ncbi.nlm.nih.gov/42764208/

The image shows details about the article linked in the post. It was published in the journal Drug Testing and Analysis. The title of the article is, "Supercritical Fluid Chromatography for Expedited Sample Clean-Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound."

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/09/2026

The PCC is heading to Chattanooga for the 2026 Science Symposium hosted by one of our founding members, USADA. We’re looking forward to a weekend full of updates, findings, and real-world anti-doping applications from top labs and researchers globally. Learn more: www.usada.org/science-rese...

This is a screenshot from the link in the post. It shows the Science and Research page of the USADA website.

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Partnership for Clean Competition @pccantidoping.bsky.social · 23/09/2026

Steroids are one of the most common substances of abuse for athletes who dope, but improved performance comes with a cost. In our new podcast episode, we talked Dr. Aaron Baggish about what athletes are truly risking when they decide to use performance enhancing drugs.

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Partnership for Clean Competition @pccantidoping.bsky.social · 21/09/2026

Authors review anti-doping applications of mass spectrometry, particularly advanced platforms. They also examine studies to date on microsampling, microextraction, and other sample pretreatment approaches. This may help labs choose methods that best fit their needs. pubmed.ncbi.nlm.nih.gov/42609009/

The image shows details about the paper linked in the post. It was published in the journal Critical Reviews in Analytical Chemistry. The title of the article is, "Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies."

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/09/2026

Lead author Dr. David J. Handelsman has received PCC funding to support his research. #antidoping #cleansport #drugtesting

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/09/2026

Authors tested the reproducibility of serum androgen profiles in 5,500+ samples from 1,600+ elite athletes. Their data provide insights into the expected variability of serum T, DHT, A4, and their ratios. This may help identify abnormal variations in the ABP. 🚫💊 🧪 pubmed.ncbi.nlm.nih.gov/42374920/

The image shows details about the article linked in the post. It was published in the journal Drug Testing and Analysis, and the title of the article is, "Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes."

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Partnership for Clean Competition @pccantidoping.bsky.social · 16/09/2026

Senior author Dr. Günter Gmeiner has previously been awarded PCC research funding. #antidoping #cleansport #testosterone #drugtesting

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Partnership for Clean Competition @pccantidoping.bsky.social · 16/09/2026

Authors developed and validated highly sensitive methods to detect T-esters in urine sample. With this approach, doping with exogenous testosterone can be directly identified using just urine samples. This is especially valuable if a blood sample was not collected. pubmed.ncbi.nlm.nih.gov/42309655/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing And Analysis. The title of the paper is, "Detection of Testosterone Esters in Urine: Evidence of Trace-Level Detectability in Doping Control Samples."

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Partnership for Clean Competition @pccantidoping.bsky.social · 15/09/2026

He shared promising preliminary findings from this work, important limitations, and how these kinds of models could continue to enhance anti-doping analyses in the future. Listen to the full episode here: cleancompetition.org/anti-doping-... #science #podcast #antidoping #machinelearning #plasma

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Partnership for Clean Competition @pccantidoping.bsky.social · 15/09/2026

Accurately estimating plasma volume matters in anti-doping. In this podcast episode, Dr. Bastien Krumm discussed his work developing a machine learning approach to estimate the volume of plasma in blood samples, and how this can help with interpreting Athlete Biological Passport data.

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/09/2026

Senior author Dr. Mario Thevis has previously received PCC funding to support his research. #antidoping #cleansport #steroids #masking #science

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/09/2026

To better understand how RU 58841 may impact ABP interpretation, authors examined the drug's metabolism & the extent of systemic exposure. Though the drug & its metabolites were detected in urine & dried blood, 1 topical dose didn't confound the ABP steroid profile. pubmed.ncbi.nlm.nih.gov/42615108/

analyticalsciencejournals.onlinelibrary.wiley.com

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen-dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to asse...

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Partnership for Clean Competition @pccantidoping.bsky.social · 11/09/2026

What challenges & questions remain in anti-doping social sciences research? Authors critically examine the state of the science & consider steps towards meaningful progress. They advocate for further research capacity-building, diversifying models, & other changes. pubmed.ncbi.nlm.nih.gov/41371322/

The image shows details about the article linked in the post. It was published in the journal Psychology of Sport and Exercise. The title of the article is, "Progress or performance in anti-doping (social science) research? A critical reflection on achievements and future directions."

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Partnership for Clean Competition @pccantidoping.bsky.social · 09/09/2026

Troponin activators are prohibited at all times in sport. Authors developed a rapid, simple, sensitive, and reliable method to screen for 6 troponin activators using dried urine spots. The dried urine spot samples had higher long-term stability versus liquid urine. pubmed.ncbi.nlm.nih.gov/42447638/

The image provides details about the paper linked in the post. It was published in the Journal of Chromatography A. The title of the paper is, "Dried urine spot strategy coupled with UHPLC-MS/MS for the analysis of troponin activators."

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Partnership for Clean Competition @pccantidoping.bsky.social · 08/09/2026

Does machine learning have the potential to improve plasma volume estimation? In our latest podcast episode, we talked with Dr. Bastien Krumm about factors that influence plasma volume fluctuations and what they mean for the athlete biological passport.

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Partnership for Clean Competition @pccantidoping.bsky.social · 04/09/2026

Authors used advanced analytic techniques to identify an unknown compound found in a supplement purchased online. The compound was identified as 6-BrAED, a designer steroid that is prohibited at all times as a non-approved substance. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

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Partnership for Clean Competition @pccantidoping.bsky.social · 02/09/2026

Increasing efficiency, cost-effectiveness, sensitivity, specificity, & sustainability are key goals in anti-doping. In line with these goals, authors successfully applied the Bar Adsorptive MicroExtraction method to identify cocaine and 3 metabolites in human urine. www.nature.com/articles/s41...

The image shows details about the article linked in the post. It was published in the journal Scientific Reports. The title of the article is, "Bar adsorptive microextraction for the qualitative detection of cocaine and its metabolites in urine for anti-doping control."

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Partnership for Clean Competition @pccantidoping.bsky.social · 01/09/2026

Kara also plans to build upon existing HRMS methods to improve specificity and sensitivity. She is a professor at the University of California San Francisco and a recipient of PCC funding. Listen to the full episode here: cleancompetition.org/anti-doping-...

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Partnership for Clean Competition @pccantidoping.bsky.social · 01/09/2026

Can a new high-resolution mass spectrometry (HRMS) approach improve detection of small molecule doping agents? Don’t miss our latest podcast episode with Dr. Kara Lynch where she discusses work establishing HRMS as a method for doping analysis.

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Partnership for Clean Competition @pccantidoping.bsky.social · 31/08/2026

Anti-doping requires contributions from many experts. Drs. Susan Backhouse & Laurie Patterson describe how psychological research has enhanced our understanding of doping in sport. They describe scientific advances, challenges, & areas for future research. 🚫💊 🧪 www.sciencedirect.com/.../pii/S146...

The image shows details about the article linked in the text. It was published in the journal Psychology of Sport and Exercise. The title of the article is, "Bridging research and practice in the psychology of doping in sport: Reflections and future directions."

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Partnership for Clean Competition @pccantidoping.bsky.social · 28/08/2026

Senior author Dr. Mario Thevis has previously received PCC funding to support his research. #antidoping #drugtesting #analyticalchemistry #MassSpectrometry

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Partnership for Clean Competition @pccantidoping.bsky.social · 28/08/2026

To avoid doping detection, synthetic urine may be substituted or used to dilute an authentic sample. Authors examined approaches to detect synthetic urine. All approaches flagged pure synthetic urine. In particular, EA-IRMS could complement anti-doping analyses. pubmed.ncbi.nlm.nih.gov/42312799/

This image shows details about the paper linked in the post. It was published in the journal Drub Testing And Analysis. The title of the paper is, "Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC-MS/MS and LC-MS/MS Analysis."

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Partnership for Clean Competition @pccantidoping.bsky.social · 27/08/2026

The following article by the International Paralympic Committee (IPC) shares some other exciting highlights to look out for on the road to LA28. Read the full article here: bit.ly/4zGmgDZ #LA28 #RoadtoLA #ParaSport #Paralympics

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Partnership for Clean Competition @pccantidoping.bsky.social · 27/08/2026

We’re two years away from the Opening Ceremony of the 2028 Paralympic Games! This will be the first ever Paralympics hosted in Los Angeles. The 2024 Paris Paralympic Games saw nearly 2,700 samples collected, with athletes from 112 out of 169 delegations tested at least once.

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Partnership for Clean Competition @pccantidoping.bsky.social · 26/08/2026

Results also highlighted that all compounds examined were detectable for at least 2 months in dried blood spots without cold storage. Dried blood spots could help preserve sample integrity & reduce shipping costs. Dr. Peter Van Eenoo is a prior recipient of PCC research funding.

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Partnership for Clean Competition @pccantidoping.bsky.social · 26/08/2026

Multi-step sample preparation and analysis workflows add time and cost to anti-doping analyses. Researchers developed and validated a rapid, streamlined, and harmonized workflow for the detection of 54 prohibited substances in dried blood spots, serum, and plasma. 🚫💊 🧪 pubs.rsc.org/an/article-a...

The image provides detail about the paper linked in the post. It was published in the journal Analyst. The title of the paper is, "Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices."

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Partnership for Clean Competition @pccantidoping.bsky.social · 25/08/2026

High-Resolution Mass Spectrometry (HRMS) is a critical tool for identifying and differentiating small molecules in anti-doping analyses. In our new podcast episode, we talk with PCC grant recipient Dr. Kara Lynch.

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/08/2026

If you missed the deadline for this round, LOIs for our spring application cycle will open on September 2 and are due February 1. Full applications can be submitted using the link below. Submit your application here: proposalcentral.com

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/08/2026

Mark your calendars: our full application deadline is quickly approaching. If you submitted an LOI/Pre-Application and were invited to submit a full application, be sure to log in and complete your application by September 1.

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Partnership for Clean Competition @pccantidoping.bsky.social · 21/08/2026

In #antidoping samples, it can be difficult to distinguish steroids with similar molecular structures. Authors showed how cryogenic gas-phase infrared spectroscopy can identify & distinguish steroids with very similar structures when an ion mobility approach could not. pubs.acs.org/amachv/artic...

The image shows details about the paper linked in the post. It was published in the journal Measurement Science, and the title of the article is, "Steroid Fingerprinting with Cryogenic Gas-Phase Infrared Spectroscopy."

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Partnership for Clean Competition @pccantidoping.bsky.social · 19/08/2026

Blood doping is especially hard to detect in homogeneous populations. Scientists made a tailored panel for antigen markers from red blood cells & platelets that detected simulated transfusion scenarios. Population-specific panels may improve blood doping detection. pubmed.ncbi.nlm.nih.gov/42338234/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing and Analysis. The title of the article is, "Exploring the Potential of Population-Optimized Red Blood Cell Antigens and Platelet HLA Typing for Homologous Blood Transfusion Detection in Japanese Athletes."

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/08/2026

Adam's story highlights the importance of keeping the athlete experience at the center of anti-doping policies and practices. Listen to the full episode here: cleancompetition.org/anti-doping-...

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/08/2026

Don't miss the latest episode of the Anti-Doping Podcast featuring Adam Nelson. Adam is a three-time Olympian in the shot put. His silver medal from the 2004 games was upgraded to gold after a competitor was disqualified for a doping violation.

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Partnership for Clean Competition @pccantidoping.bsky.social · 17/08/2026

Senior author Dr. Mario Thevis has previously received PCC funding to support his research. #antidoping #cleansport #drugtesting #SARMS #chemistry

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Partnership for Clean Competition @pccantidoping.bsky.social · 17/08/2026

This is the 1st report of quantitative excretion data for the M5-b long-term metabolite of LGD-4033 w/ micro-dose conditions. Authors examined excretion for 1-5 day administration at 3 doses, providing valuable evidence for interpreting adverse analytical findings. pubmed.ncbi.nlm.nih.gov/42547066/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing and Analysis. The title of the paper is, "Quantification of the Carboxylated LGD-4033 Long-Term Metabolite in Human Micro-Dose Excretion Study Urine Samples."

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/08/2026

The cost of #antidoping analyses is a challenge. Authors made a low-cost electrochemical platform to screen for the prohibited steroid danazol. It was effective in spiked water & synthetic urine/saliva. Future work can validate it & assess potential applications. pubmed.ncbi.nlm.nih.gov/42494320/

The image shows details of the article linked in the post. It was published in the journal Analytical Methods. The title of the article is, "A low-cost electrochemical screening platform for danazol in anti-doping analysis."

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Partnership for Clean Competition @pccantidoping.bsky.social · 12/08/2026

National anti-doping organizations (NADOs) are key players in the global fight against doping. European NADO leaders shared insights on their challenges & strategic needs. The findings can inform the new anti-doping policies & capacity-building efforts. pubmed.ncbi.nlm.nih.gov/42311486/

This image shows details of the article linked in the post. It was published in the journal Frontiers in Sports and Active Living, and the title is, "Strategic priorities and barriers to an effective anti-doping programme: views and opinions of European NADO leaders."

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Partnership for Clean Competition @pccantidoping.bsky.social · 11/08/2026

Our new podcast episode features Olympic gold medalist Adam Nelson. Adam was awarded a silver medal in the shot put at the 2004 Olympics that was later upgraded to gold after it was discovered that a competitor was disqualified for doping.

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