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Partnership for Clean Competition @pccantidoping.bsky.social · 01/10/2026

Authors developed methods to detect the synthetic peptide retatrutide & reported on excretion profiles in plasma & urine. It was only detectable in plasma & had a long detection window (~50 days). This shows plasma is a suitable matrix for retatrutide detection. pmc.ncbi.nlm.nih.gov/articles/PMC...

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Partnership for Clean Competition @pccantidoping.bsky.social · 30/09/2026

We're excited to share findings from Dr. John Eiler's PCC-funded research. He developed an orbitrap-based mass spectrometry method that provides multidimensional isotope fingerprints. The approach could help identify the sources of steroids in anti-doping samples. pubmed.ncbi.nlm.nih.gov/42752109/

The image shows details about the paper linked in the post. It was published in the journal Analytical Chemistry. The title of the article is, "Fragment-Resolved Carbon and Hydrogen Isotope Analysis of Urinary Steroids by Orbitrap Mass Spectrometry."

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Partnership for Clean Competition @pccantidoping.bsky.social · 29/09/2026

Steroids have long been banned in sport, but the risks of using them go beyond sitting out from competition. Dr. Aaron Baggish discussed the long-term consequences of doping and why doing it with medical supervision doesn’t necessarily make it safer. cleancompetition.org/anti-doping-podcast/181

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Partnership for Clean Competition @pccantidoping.bsky.social · 25/09/2026

Researchers developed & validated methods to detect testosterone & its metabolites using supercritical fluid chromatography that expedite separation & evaporation steps. Results using the new method were comparable to those obtained via common HPLC-based procedures. pubmed.ncbi.nlm.nih.gov/42764208/

The image shows details about the article linked in the post. It was published in the journal Drug Testing and Analysis. The title of the article is, "Supercritical Fluid Chromatography for Expedited Sample Clean-Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound."

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/09/2026

The PCC is heading to Chattanooga for the 2026 Science Symposium hosted by one of our founding members, USADA. We’re looking forward to a weekend full of updates, findings, and real-world anti-doping applications from top labs and researchers globally. Learn more: www.usada.org/science-rese...

This is a screenshot from the link in the post. It shows the Science and Research page of the USADA website.

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Partnership for Clean Competition @pccantidoping.bsky.social · 23/09/2026

Steroids are one of the most common substances of abuse for athletes who dope, but improved performance comes with a cost. In our new podcast episode, we talked Dr. Aaron Baggish about what athletes are truly risking when they decide to use performance enhancing drugs.

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Partnership for Clean Competition @pccantidoping.bsky.social · 21/09/2026

Authors review anti-doping applications of mass spectrometry, particularly advanced platforms. They also examine studies to date on microsampling, microextraction, and other sample pretreatment approaches. This may help labs choose methods that best fit their needs. pubmed.ncbi.nlm.nih.gov/42609009/

The image shows details about the paper linked in the post. It was published in the journal Critical Reviews in Analytical Chemistry. The title of the article is, "Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies."

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/09/2026

Authors tested the reproducibility of serum androgen profiles in 5,500+ samples from 1,600+ elite athletes. Their data provide insights into the expected variability of serum T, DHT, A4, and their ratios. This may help identify abnormal variations in the ABP. 🚫💊 🧪 pubmed.ncbi.nlm.nih.gov/42374920/

The image shows details about the article linked in the post. It was published in the journal Drug Testing and Analysis, and the title of the article is, "Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes."

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Partnership for Clean Competition @pccantidoping.bsky.social · 16/09/2026

Authors developed and validated highly sensitive methods to detect T-esters in urine sample. With this approach, doping with exogenous testosterone can be directly identified using just urine samples. This is especially valuable if a blood sample was not collected. pubmed.ncbi.nlm.nih.gov/42309655/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing And Analysis. The title of the paper is, "Detection of Testosterone Esters in Urine: Evidence of Trace-Level Detectability in Doping Control Samples."

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Partnership for Clean Competition @pccantidoping.bsky.social · 15/09/2026

Accurately estimating plasma volume matters in anti-doping. In this podcast episode, Dr. Bastien Krumm discussed his work developing a machine learning approach to estimate the volume of plasma in blood samples, and how this can help with interpreting Athlete Biological Passport data.

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/09/2026

To better understand how RU 58841 may impact ABP interpretation, authors examined the drug's metabolism & the extent of systemic exposure. Though the drug & its metabolites were detected in urine & dried blood, 1 topical dose didn't confound the ABP steroid profile. pubmed.ncbi.nlm.nih.gov/42615108/

analyticalsciencejournals.onlinelibrary.wiley.com

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen-dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to asse...

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Partnership for Clean Competition @pccantidoping.bsky.social · 11/09/2026

What challenges & questions remain in anti-doping social sciences research? Authors critically examine the state of the science & consider steps towards meaningful progress. They advocate for further research capacity-building, diversifying models, & other changes. pubmed.ncbi.nlm.nih.gov/41371322/

The image shows details about the article linked in the post. It was published in the journal Psychology of Sport and Exercise. The title of the article is, "Progress or performance in anti-doping (social science) research? A critical reflection on achievements and future directions."

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Partnership for Clean Competition @pccantidoping.bsky.social · 09/09/2026

Troponin activators are prohibited at all times in sport. Authors developed a rapid, simple, sensitive, and reliable method to screen for 6 troponin activators using dried urine spots. The dried urine spot samples had higher long-term stability versus liquid urine. pubmed.ncbi.nlm.nih.gov/42447638/

The image provides details about the paper linked in the post. It was published in the Journal of Chromatography A. The title of the paper is, "Dried urine spot strategy coupled with UHPLC-MS/MS for the analysis of troponin activators."

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Partnership for Clean Competition @pccantidoping.bsky.social · 08/09/2026

Does machine learning have the potential to improve plasma volume estimation? In our latest podcast episode, we talked with Dr. Bastien Krumm about factors that influence plasma volume fluctuations and what they mean for the athlete biological passport.

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Partnership for Clean Competition @pccantidoping.bsky.social · 04/09/2026

Authors used advanced analytic techniques to identify an unknown compound found in a supplement purchased online. The compound was identified as 6-BrAED, a designer steroid that is prohibited at all times as a non-approved substance. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

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Partnership for Clean Competition @pccantidoping.bsky.social · 02/09/2026

Increasing efficiency, cost-effectiveness, sensitivity, specificity, & sustainability are key goals in anti-doping. In line with these goals, authors successfully applied the Bar Adsorptive MicroExtraction method to identify cocaine and 3 metabolites in human urine. www.nature.com/articles/s41...

The image shows details about the article linked in the post. It was published in the journal Scientific Reports. The title of the article is, "Bar adsorptive microextraction for the qualitative detection of cocaine and its metabolites in urine for anti-doping control."

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Partnership for Clean Competition @pccantidoping.bsky.social · 01/09/2026

Can a new high-resolution mass spectrometry (HRMS) approach improve detection of small molecule doping agents? Don’t miss our latest podcast episode with Dr. Kara Lynch where she discusses work establishing HRMS as a method for doping analysis.

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Partnership for Clean Competition @pccantidoping.bsky.social · 31/08/2026

Anti-doping requires contributions from many experts. Drs. Susan Backhouse & Laurie Patterson describe how psychological research has enhanced our understanding of doping in sport. They describe scientific advances, challenges, & areas for future research. 🚫💊 🧪 www.sciencedirect.com/.../pii/S146...

The image shows details about the article linked in the text. It was published in the journal Psychology of Sport and Exercise. The title of the article is, "Bridging research and practice in the psychology of doping in sport: Reflections and future directions."

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Partnership for Clean Competition @pccantidoping.bsky.social · 28/08/2026

To avoid doping detection, synthetic urine may be substituted or used to dilute an authentic sample. Authors examined approaches to detect synthetic urine. All approaches flagged pure synthetic urine. In particular, EA-IRMS could complement anti-doping analyses. pubmed.ncbi.nlm.nih.gov/42312799/

This image shows details about the paper linked in the post. It was published in the journal Drub Testing And Analysis. The title of the paper is, "Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC-MS/MS and LC-MS/MS Analysis."

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Partnership for Clean Competition @pccantidoping.bsky.social · 27/08/2026

We’re two years away from the Opening Ceremony of the 2028 Paralympic Games! This will be the first ever Paralympics hosted in Los Angeles. The 2024 Paris Paralympic Games saw nearly 2,700 samples collected, with athletes from 112 out of 169 delegations tested at least once.

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Partnership for Clean Competition @pccantidoping.bsky.social · 26/08/2026

Multi-step sample preparation and analysis workflows add time and cost to anti-doping analyses. Researchers developed and validated a rapid, streamlined, and harmonized workflow for the detection of 54 prohibited substances in dried blood spots, serum, and plasma. 🚫💊 🧪 pubs.rsc.org/an/article-a...

The image provides detail about the paper linked in the post. It was published in the journal Analyst. The title of the paper is, "Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices."

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Partnership for Clean Competition @pccantidoping.bsky.social · 25/08/2026

High-Resolution Mass Spectrometry (HRMS) is a critical tool for identifying and differentiating small molecules in anti-doping analyses. In our new podcast episode, we talk with PCC grant recipient Dr. Kara Lynch.

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/08/2026

Mark your calendars: our full application deadline is quickly approaching. If you submitted an LOI/Pre-Application and were invited to submit a full application, be sure to log in and complete your application by September 1.

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Partnership for Clean Competition @pccantidoping.bsky.social · 21/08/2026

In #antidoping samples, it can be difficult to distinguish steroids with similar molecular structures. Authors showed how cryogenic gas-phase infrared spectroscopy can identify & distinguish steroids with very similar structures when an ion mobility approach could not. pubs.acs.org/amachv/artic...

The image shows details about the paper linked in the post. It was published in the journal Measurement Science, and the title of the article is, "Steroid Fingerprinting with Cryogenic Gas-Phase Infrared Spectroscopy."

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Partnership for Clean Competition @pccantidoping.bsky.social · 19/08/2026

Blood doping is especially hard to detect in homogeneous populations. Scientists made a tailored panel for antigen markers from red blood cells & platelets that detected simulated transfusion scenarios. Population-specific panels may improve blood doping detection. pubmed.ncbi.nlm.nih.gov/42338234/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing and Analysis. The title of the article is, "Exploring the Potential of Population-Optimized Red Blood Cell Antigens and Platelet HLA Typing for Homologous Blood Transfusion Detection in Japanese Athletes."

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Partnership for Clean Competition @pccantidoping.bsky.social · 18/08/2026

Don't miss the latest episode of the Anti-Doping Podcast featuring Adam Nelson. Adam is a three-time Olympian in the shot put. His silver medal from the 2004 games was upgraded to gold after a competitor was disqualified for a doping violation.

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Partnership for Clean Competition @pccantidoping.bsky.social · 17/08/2026

This is the 1st report of quantitative excretion data for the M5-b long-term metabolite of LGD-4033 w/ micro-dose conditions. Authors examined excretion for 1-5 day administration at 3 doses, providing valuable evidence for interpreting adverse analytical findings. pubmed.ncbi.nlm.nih.gov/42547066/

The image shows details about the paper linked in the post. It was published in the journal Drug Testing and Analysis. The title of the paper is, "Quantification of the Carboxylated LGD-4033 Long-Term Metabolite in Human Micro-Dose Excretion Study Urine Samples."

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/08/2026

The cost of #antidoping analyses is a challenge. Authors made a low-cost electrochemical platform to screen for the prohibited steroid danazol. It was effective in spiked water & synthetic urine/saliva. Future work can validate it & assess potential applications. pubmed.ncbi.nlm.nih.gov/42494320/

The image shows details of the article linked in the post. It was published in the journal Analytical Methods. The title of the article is, "A low-cost electrochemical screening platform for danazol in anti-doping analysis."

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Partnership for Clean Competition @pccantidoping.bsky.social · 12/08/2026

National anti-doping organizations (NADOs) are key players in the global fight against doping. European NADO leaders shared insights on their challenges & strategic needs. The findings can inform the new anti-doping policies & capacity-building efforts. pubmed.ncbi.nlm.nih.gov/42311486/

This image shows details of the article linked in the post. It was published in the journal Frontiers in Sports and Active Living, and the title is, "Strategic priorities and barriers to an effective anti-doping programme: views and opinions of European NADO leaders."

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Partnership for Clean Competition @pccantidoping.bsky.social · 11/08/2026

Our new podcast episode features Olympic gold medalist Adam Nelson. Adam was awarded a silver medal in the shot put at the 2004 Olympics that was later upgraded to gold after it was discovered that a competitor was disqualified for doping.

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Partnership for Clean Competition @pccantidoping.bsky.social · 10/08/2026

Authors compared measurements of 2 steroids using GC-qTOF and LC-MS/MS. They showed good agreement, but failure to reach WADA's LOQs highlight a need for clearer acceptance criteria for use of HRMS approaches to identify substances. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

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Partnership for Clean Competition @pccantidoping.bsky.social · 07/08/2026

Collecting venous blood for anti-doping testing is more invasive & requires trained personnel. Authors examined ABP hematological markers from venous vs liquid capillary blood & found liquid capillary blood could serve as an alternative for most hematological markers. www.ovid.com/10.1249/MSS....

The image shows details about the paper linked in the post. It was published in the journal Medicine & Science in Sports & Exercise. The title of the paper is, "Capillary Blood as a Potential New Matrix for the Athlete Biological Passport: A Field-Based Comparison Study."

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Partnership for Clean Competition @pccantidoping.bsky.social · 06/08/2026

Pre-applications are now closed, and full applications are open. If you submitted a pre-application for a research grant or fellowship, be sure to complete your full application by September 1 to be considered for this round of funding. Submit yours here: proposalcentral.com

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Partnership for Clean Competition @pccantidoping.bsky.social · 05/08/2026

How athletes & DCOs perceive remote sampling is important for wider adoption of remote testing. In this PCC-funded work, authors asked athletes & DCOs about transparency, trust, perceived benefits, risk, perceived legitimacy, & their attitude toward remote sampling. pubmed.ncbi.nlm.nih.gov/42453616/

The image shows details about the paper linked in the post. It was published in the journal Frontiers in Sports and Active Living. The title of the article is, "When they don't come around: how athletes and DCOs perceive the legitimacy of a remote sampling system in anti-doping testing."

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Partnership for Clean Competition @pccantidoping.bsky.social · 04/08/2026

Communicating the results of your scientific research can increase the impacts of your findings. In our most recent podcast episode, we talked with Dr. Caroline Rickards about the importance of effectively conveying the significance of your research with audiences.

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Partnership for Clean Competition @pccantidoping.bsky.social · 03/08/2026

RNA-based biomarkers like messenger RNAs and microRNAs have shown promise as complementary tools for the Athlete Biological Passport. This article reviews studies on RNA-based biomarkers, methods of measurement, and important considerations for implementation. www.sciencedirect.com/science/chap...

The image shows details about the paper linked in the post. It was published in the journal Advances in Clinical Chemistry. The title of the paper is, "RNA biomarkers in antidoping."

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Partnership for Clean Competition @pccantidoping.bsky.social · 31/07/2026

Distinguishing out-of-competition MP use & permitted administration in competition from prohibited use is important. Authors examined MP urinary excretion profiles after oral administration & found the washout period & urinary MRL are appropriate to detect oral use. pubmed.ncbi.nlm.nih.gov/42343043/

This image shows details about the article linked in the post. It was published in the journal Clinical Pharmacokinetics, and the title of the article is, "Revisited Pharmacokinetic Profiles of Methylprednisolone in Plasma and Urine After Single and Multiple Oral Administrations: Relevance in Sports Drug Testing."

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Partnership for Clean Competition @pccantidoping.bsky.social · 30/07/2026

While there are many benefits to using dried blood spot sampling in anti-doping, analyses are limited by the small amount of sample available. To get the most out of a dried blood spot sample, authors developed & validated a method that detects 91 target compounds. pubmed.ncbi.nlm.nih.gov/42345615/

The image shows details about the paper linked in the post. It was published in the journal Biomedical Chromatography. The title of the article is, "Dried Blood Spots for Doping Purpose-Two-Step Protocol for Analysis of Non-Threshold Substances and Anabolic Steroid Esters From One Spot/Pebble."

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Partnership for Clean Competition @pccantidoping.bsky.social · 29/07/2026

Reported doping prevalence rates vary across studies, & using indirect estimation models involves complex methods & modeling assumptions. Authors discuss developments, challenges, & trends in the field for applying indirect estimation models to doping prevalence. pmc.ncbi.nlm.nih.gov/articles/PMC...

This image shows details about the article linked in the post. It was published in the journal Sports (Basel). The title of the article is, "Charting the Scientific Landscape of Indirect Estimation Models in Doping Prevalence Research: A Bibliometric Analysis with Narrative Appraisal."

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Partnership for Clean Competition @pccantidoping.bsky.social · 28/07/2026

How can you enhance the real-world impacts of the work you’re doing in the lab? Share it broadly. In our latest podcast episode, we talked with Dr. Caroline Rickards about the importance of effective science communication.

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Partnership for Clean Competition @pccantidoping.bsky.social · 27/07/2026

Don’t forget to submit your pre-application for a research grant or fellowship by August 1. Our pre-applications are now hosted on Altum and can be accessed through the link below.

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Partnership for Clean Competition @pccantidoping.bsky.social · 24/07/2026

The drug tesofensine induces weight loss & is prohibited in-competition. Tesofensine use was detectable up to 500 hours, but out-of-competition use w/ recommended doses is unlikely to produce urinary concentrations high enough to trigger adverse analytical findings. pubmed.ncbi.nlm.nih.gov/42320973/

analyticalsciencejournals.onlinelibrary.wiley.com

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC-HRMS/MS identified...

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Partnership for Clean Competition @pccantidoping.bsky.social · 23/07/2026

Are you looking to jump start your career in anti-doping? A PCC Fellowship could be right for you. Our Fellowship Program supports qualified researchers who demonstrate a strong interest and show potential for significant long-term impacts in anti-doping disciplines.

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Partnership for Clean Competition @pccantidoping.bsky.social · 22/07/2026

Estimating doping prevalence is complex, & scientists developed different models to overcome challenges. Authors reviewed studies using indirect estimation models to examine the prevalence of doping in competitive & recreational athletes in 1 or multiple sports. link.springer.com/article/10.1...

The image shows details about the paper linked in the post. It was published in the journal Sports Medicine - Open. The title of the article is, "Doping Prevalence in Sport from Indirect Estimation Models: A Systematic Review and Meta-analysis."

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Partnership for Clean Competition @pccantidoping.bsky.social · 21/07/2026

We’re two years out from the 2028 Olympic & Paralympic Games, the first Games hosted on U.S. soil since 2002. According to ITA, the Paris Games saw over 6000 samples collected from over 4100 athletes with nearly 40% of athletes tested at least once before or during competition.

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Partnership for Clean Competition @pccantidoping.bsky.social · 20/07/2026

Researchers developed a rapid, sensitive, and reliable high-performance liquid chromatography-mass spectrometry method to detect 7 troponin activators in urine and serum. Their results suggest this approach could be useful for routine #antidoping analyses. www.sciencedirect.com/science/arti...

This image shows details about the paper linked in the post. It was published in the Journal of Chromatography B, and the title of the paper is, "Validation of an HPLC-MS method for simultaneous determination of seven troponin activators in human urine and serum for doping control."

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Partnership for Clean Competition @pccantidoping.bsky.social · 17/07/2026

The PCC was pleased to provide funding to support this research examining how athletes & Doping Control Officers perceive remote sampling in anti-doping. Authors share actionable recommendations for anti-doping organizations to pilot new remote sampling protocols. www.frontiersin.org/journals/spo...

The image provides details about the article linked in the post. It was published in the journal Front. Sports. Act. Living, and the title of the article is, "Exploring the perceptions of athletes and DCOs on the remote sampling procedure in anti-doping testing: shifting control to burden."

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Partnership for Clean Competition @pccantidoping.bsky.social · 16/07/2026

The next PCC Research Grant and Fellowship pre-application deadline is just around the corner on August 1st. We have some exciting PCC-funded research projects underway.

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Partnership for Clean Competition @pccantidoping.bsky.social · 15/07/2026

Athlete Support Personnel (ASP) can have major impacts on the behaviors athletes engage in & decisions they make. Research shows different ASP types influence different doping-related behaviors, suggesting a need for stronger role-specific anti-doping education. pmc.ncbi.nlm.nih.gov/articles/PMC...

This image shows details about the paper linked in the post. It was published in the journal Healthcare (Basel). The title of the paper is, "The Role of Athlete Support Personnel in Anti-Doping: A Narrative Review of Contemporary Evidence."

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Partnership for Clean Competition @pccantidoping.bsky.social · 14/07/2026

In our latest podcast episode, we talked with Head of the Athletics Integrity Unit (AIU), Brett Clothier, about what AIU is doing to raise the bar when it comes to doping detection. Brett shared some of AIU’s goals as well as what challenges they are working to overcome.

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