Reposted by Paul LayugCancerCare Manitoba @cancercaremb.bsky.social · 16/07/2026Congratulations to Dr. Yale Michaels on receiving a $550,000 Canadian Cancer Society Grant to advance the next generation of CAR T-cell therapy for cancer. His research aims to develop stem cell-based CAR T treatments that could reduce costs, shorten wait times, and make it accessible for patients. 031
Paul Layug @pauljerardl.bsky.social · 14/01/2026Check out our protocol for streamlined isolation and immunophenotyping of leukocytes from various mouse tissues! Excited to implement these in our in vivo mouse models to better understand the immune system and harness it for safe and effective immunotherapies. @um-radyfhs.bsky.social 064
Reposted by Paul LayugPROMISE Theme @promise-theme.bsky.social · 27/11/2025Join us for the last CHRIM Research Rounds of the termon Dec 1st! We'll hear from Dr. Yale Michaels and Huda Alfarekh, sharing their presentation "Broadening access to genetically modified cell therapies through cost-effective manufacturing." See you there! #RPOMISE #CHRIM #CCMB 033
Paul Layug @pauljerardl.bsky.social · 04/11/2025And thank you to the Paul Albrechtsen Research Institute @cancercaremb.bsky.social for supporting my attendance through the Dr. Leigh Murphy Manitoba Tumour Bank Travel Award! 010
Paul Layug @pauljerardl.bsky.social · 04/11/2025Highlights from a wonderful #CCRC2025. Thank you to the organizers for the opportunity to give a lightning talk on our work in creating better and safer CAR T cell therapies. It was a fruitful 3 days of networking and great science! The future of cancer care is alive in 🇨🇦 131
Reposted by Paul LayugBritt Drogemoller @brittdrog.bsky.social · 01/10/2025Interested in using single cell technologies to unravel the molecular origins and evolution of ovarian cancer? We are looking for a graduate student! More details here 👇 024
Reposted by Paul LayugJulie Lajoie @julielajoie13.bsky.social · 12/04/2025If you are a Canadian Researcher, faculty member, RA, PDF or graduate student in Canada please consider signing our letter to ask for increase of funding in research to make Canada a leader in science and build a stronger economy. docs.google.com/document/d/1...docs.google.comNational LetterOpen Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne... 041
Paul Layug @pauljerardl.bsky.social · 09/04/2025Thank you BioCanRx Cancer Stakeholder Alliance for inviting me to participate in this year's Learning Institute! I couldn't think of a better way of celebrating #DaffodilMonth than with my #TeamManitoba Patient Scholars, Sandra and Cynthia 💛🩷💚 021
Paul Layug @pauljerardl.bsky.social · 09/04/2025...Meghan Kates' award-winning HQP plenary talk on immuno-metabolism, Dr. Livnat Jerby's @stanford.edu groundbreaking synbio technologies, and the plenaries ending on a high note with Dr. Denis Migliorini's novel CAR designs for high-grade gliomas. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025My personal favourites from this year's Summit included: Dr. Katy Rezvani's @mdanderson.bsky.social scientific keynote on their amazing translational discoveries on CAR-NK, Milan Heck's eye-opening patient partner keynote, Shannon Snelling's wonderful patient-grad student partnership program... 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025This plenary was concluded by Dr. Christian Hinrichs @rutgerscancer.bsky.social who presented their progress in utilizing cell therapies against HPV-related epithelial cancers. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025HQP Leanne Palichuk (Lee Lab @ucalgary.bsky.social) talked about her work on utilizing rare DN T cells to improve the potency of anti-tumour T cells against relapsed pediatric AML. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025Then, Dr. Marie Bleakley @fredhutch.bsky.social featured their innovative work on TCR T cells against minor histocompatibility antigens for patients who relapse post-HSCT. 110
Paul Layug @pauljerardl.bsky.social · 09/04/2025First, Dr. Doug Mahoney @ucalgary.bsky.social presented on their Canadian clinical trial using GCAR1 CAR T cells, which target GPNMB on sarcomas. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025Sandra (my Patient Scholar) and I were tasked to present on Plenary 1: Clinical Testing of Innovative T cell Therapies for Cancer. This thought- (and hope-) provoking plenary highlighted novel T-cell therapies and their progress towards clinical utility. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025This year, we had 5 outstanding plenaries on T cell therapies, non-T players of the immune system, immuno-metabolism, spatial immunobiology, and mRNA-based immunotherapies. 100
Paul Layug @pauljerardl.bsky.social · 09/04/2025That's a wrap for this year's BioCanRx #Summit4CI! Here are some "bites" from Canada's Immunotherapy network from the lens of a Learning Institute Scholar— a thread. #oncosky #cansky #immunosky 130
Paul Layug @pauljerardl.bsky.social · 01/04/2025Thanks @umbmg.bsky.social! Looking forward to connecting with folks attending #BioCanRx #Summit4CI this weekend! 020
Reposted by Paul LayugWaggoner Lab @labwaggoner.bsky.social · 17/03/2025Design of sensitive monospecific and bispecific synthetic chimeric TCRs for cancer therapy @naturecancer.bsky.social @sylvainsimon.bsky.social www.nature.com/articles/s43... 062
Reposted by Paul LayugMichael de Adder @deadder.bsky.social · 11/02/2025It's 𝗜𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗗𝗮𝘆 𝗼𝗳 𝗪𝗼𝗺𝗲𝗻 𝗮𝗻𝗱 𝗚𝗶𝗿𝗹𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲. I only know because this is being shared a lot across all platforms. 191878718
Reposted by Paul LayugWHO @who.int · 04/02/2025Today is #WorldCancerDay Did you know❓ Vaccination against #hepatitisB can help prevent liver cancer in children, while #HPV vaccination for young girls can reduce the risk of #CervicalCancer later in life. Learn more 👉bit.ly/2NeFF8B 131281341
Reposted by Paul LayugBruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · 22/01/2025Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies in 783 Patients (38 clinical trials) -Analysis in 169 patients = no pathological insertions linked to secondary malignancies -Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41... 073
Reposted by Paul LayugStylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 20/12/2024#NCB2024 In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma. www.nature.com/articles/s41...nature.comA group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell BiologyWerbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla... 182
Reposted by Paul LayugBiochemistry & Medical Genetics @umbmg.bsky.social · 07/12/2024The Department of Biochemistry and Medical Genetics at the University of Manitoba is excited to join BlueSky! Follow us for updates on our groundbreaking research, departmental achievements, and latest developments in the field! Find out more about more here: umanitoba.ca/medicine/dep...umanitoba.caMax Rady College of Medicine | University of Manitoba - Department of Biochemistry and Medical GeneticsBiochemistry is the study of the chemistry within all living organisms. Through innovative research and scholarship, we are working to understand, prevent and treat disease, including genetic disorder... 176
Reposted by Paul LayugPROMISE Theme @promise-theme.bsky.social · 06/12/2024Hello! We are the Pediatric Research in Oncology in #Manitoba: Innovation, Science, Excellence (PROMISE) theme, a dedicated research group established through the Children's Hospital Research Institute of Manitoba (CHRIM) and CancerCare Manitoba (CCMB). 043
Reposted by Paul LayugRich LeDuc (He/Him) @rich-leduc.bsky.social · 28/11/2024I've made a starter pack for the department of Biochem and Med Genetics at the University of Manitoba Rady Faculty of Health Sciences. Comment if you'd like me to add you. Please feel free to share with others. go.bsky.app/PH1RXXX 174
Reposted by Paul LayugOlivier Saulnier @olivier-saulnier.bsky.social · 24/11/2024Let's build a starter pack for childhood cancer research. Please send a message to be added! 🎗️ go.bsky.app/Tpd9QnM 2913827
Reposted by Paul LayugJohanna Joyce @johannajoyce.bsky.social · 23/11/2024Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA 3224388
Reposted by Paul LayugAleeza Gerstein @acgerstein.bsky.social · 16/11/2024I couldn't help myself, I did the thing. I'm sure people are missing (and/or are still arriving) - drop your name below, and I'll add you. #winnipeg go.bsky.app/Qj6c2ZG 72410
Paul Layug @pauljerardl.bsky.social · 17/11/2024Thanks for this! Would love to connect with more trainees here 🦋 010
Paul Layug @pauljerardl.bsky.social · 16/11/2024This is awesome- thank you! would love to join the pack! 020