Neutrophils infiltrate glioblastomas with the capacity to engage pro/anti tumoural responses. Here the authors developed proteomic workflows to stratify neutrophil heterogeneity by function. This work...

Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...

For four weeks this summer, IRR hosted local high school students as part of both the BioQuarter’s Summer Interns and University’s Career Ready programmes.

RSV infection induces lasting epigenetic and transcriptional changes in LECs, upregulating MHC-I and MHC-II, further amplified by LPS exposure. This is accompanied by increased antigen uptake, proc...

SUMMARYRespiratory viral infections cause extensive cell death in the lung epithelium, resulting from both direct viral action and exuberant immune responses. Recovery following viral infection requir...

Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...