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Pascal Grumbach

@pascal-grumbach.bsky.social

44 followers 83 following 7 posts

Almost MD | Interested in multimodal neuroimaging of psychiatric disorders

Posts Replies Media

Reposted by Pascal Grumbach

Awais Aftab @awaisaftab.bsky.social · 20/09/2025

Rewriting the Grand Plan of Clinical Neuroscience A Review of “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That” by Nicole C. Rust ( @nicolecrust.bsky.social ) www.psychiatrymargins.com/p/rewriting-...

psychiatrymargins.com

Rewriting the Grand Plan of Clinical Neuroscience

A Review of “Elusive Cures” by Nicole C. Rust

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

doi.org/10.1038/s414...

doi.org

Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes - Nature Communications

Consistent local activity reductions in autism co-localize with glutamatergic and GABAergic neurotransmission. These patterns resemble brain changes induced by ketamine, highlighting altered excitatio...

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

4) Specifically, ketamine reduced functional activity in those regions of the default mode network where it was also reduced in autism.

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

2) The consistent functional alterations in autism co-localized with distinct neurotransmitter properties, including glutamatergic (NMDA, mGluR5) and GABAergic (GABAa) neurotransmission.

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.

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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

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Reposted by Pascal Grumbach

Jonathan Repple @jonathanrepple.bsky.social · 05/09/2025

Looking for a 3-year 100% postdoc position at the intersection of mental health, neuroimaging and biological markers? Come join our team: short.sg/j/59191808

short.sg

Postdoktorandin / Postdoktorand / PostDoc – Klinik für Psychiatrie, Psychosomatik und Psychotherapie

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Reposted by Pascal Grumbach

Bratislav Misic @misicbata.bsky.social · 04/08/2025

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

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Reposted by Pascal Grumbach

Juergen Dukart @juergendukart.bsky.social · 10/04/2025

JuSpace 2.0 is now released. Key changes: - New modern UI (also standalone is now available upon request) - New visualization functionalities - Added many new PET maps - Added different cell atlases github.com/juryxy/JuSpace

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