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Patrick Forcelli

@paf1984.bsky.social
98 followers 130 following 44 posts

Neuropharmacologist @ Georgetown University, Prof & Chair, Dept of Pharmacology & Physiology. Preclinical epilepsy researcher & basal ganglia nerd. 🏳️‍🌈

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Patrick Forcelli @paf1984.bsky.social · 25/03/2026
Our topic today in our 1st year PhD students skills & ethics course was Vannevar Bush's Science, The Endless Frontier. If you haven't read it, you should. Bush outlined a vision that led to the creation of the National Science Foundation. 1/n
nsf-gov-resources.nsf.gov
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Jeremy Berg @jeremymberg.bsky.social · 17/03/2026
Action Item...Action Item...Action Item Time to comment on the Framework for the NIH-Wide Strategic Plan grants.nih.gov/grants/guide... Comments due by May 16, 2026
grants.nih.gov
NOT-OD-26-047: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fiscal Years 2027-2031
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fis...
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Max Kozlov @maxkozlov.bsky.social · 16/03/2026
Update 3/16: A very small handful of NIH apportionments have come through — with big exceptions. The ones that OMB has approved are all Congressionally mandated/earmarked. The broad discretionary funds that fund most NIH grants not yet been authorized. (1/2)
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Elizabeth West @ewbrains.bsky.social · 11/02/2026
Excited that our new paper is out today in the Journal of Neuroscience. www.jneurosci.org/content/46/6...
jneurosci.org
Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer’s Disease
Executive dysfunction can precede the accumulation of canonical neuropathological markers and severe dementia in Alzheimer’s disease (AD) patients often characterized by memory changes. Deficits in ex...
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Patrick Forcelli @paf1984.bsky.social · 30/01/2026
📢 GU Pharmacology & Physiology is hiring! Tenure-track / tenured faculty position at Georgetown University Medical Center. apply.interfolio.com/180562 Please share with your networks.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Jenna Norton @jenna-m-norton.bsky.social · 16/01/2026
Don’t let Russell Vought trick Congress into destroying science by removing multiyear funding limits from the NIH funding bill.
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Technology Connections @techconnectify.bsky.social · 08/01/2026
If it helps, people are mad at Democrats because many of their social media presences produce comms which address what's happening as though we're simply dealing with the consequences of going along with a bad restaurant recommendation. The food isn't just bad, we want to shut down the restaurant.
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Karen S Wilcox, PhD (she/her) @karenswilcoxphd.bsky.social · 30/12/2025
Sharing this piece by @katherinejwu.com - A succinct explanation about why i fear for the younger generation of scientists... www.theatlantic.com/science/2025...
theatlantic.com
The Trump Administration’s Most Paralyzing Blow to Science
Cuts to research may have spoiled the country’s appetite for bold exploration.
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Patrick Forcelli @paf1984.bsky.social · 23/12/2025
New paper out from the lab. Tahi Khan, David McFall, and team (1) found increased senescent cells in hippocampus from individuals with temporal lobe epilepsy and in mice after status epilepticus, (2) cleared senescent cells using two strategies & reduced seizures and cognitive impairment in mice.
onlinelibrary.wiley.com
Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice
Objective The pharmacological treatment of temporal lobe epilepsy (TLE), a disorder characterized by recurrent seizures and cognitive dysfunction, is limited to symptomatic control. Identifying nove...
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John Hawkinson @johnhawkinson.bsky.social · 30/09/2025
OMG this William G. Young opinion that just dropped (12:30pm) in AAUP v. Rubio. It begins with a postcard sent to Chambers and Young's reply card: "Trump has pardons and tanks, what do you have?" WGY: "We the People of the United States — you and me — have our magnificent Constitution"
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Pam Davis-Kean, PhD @umpamdk.bsky.social · 29/09/2025
Thank you all the program officers at NIH that persisted through the 2025 fiscal year and were able to fund 99% of the total FY2024 budget. I know this has take a toll on everyone at NIH. Thank you for supporting important health and behavior science and helping to keep the U.S. a leader in science.
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Carl T. Bergstrom @carlbergstrom.com · 04/06/2025
I tried something similar using ChatGPT 4.o. "I'm trying to put together a portfolio of three to five papers to highlight my breadth and depth as a research scientist. (I'm Carl Bergstrom.) Could you help me choose papers?" Here's the result.
I'm trying to put together a portfolio of three to five papers to highlight my breadth and depth as a research scientist. (I'm Carl Bergstrom.)

Could you help me choose papers?
ChatGPT said:

Absolutely, Carl. Given your broad body of work across evolutionary biology, information theory, network science, metascience, and science communication, a strong portfolio should showcase both disciplinary depth and interdisciplinary reach. A good starting structure might be:

    Foundational work in evolutionary biology or theoretical ecology

    Papers at the intersection of information theory and biology

    Work in network theory or epidemiological modeling

    Metascience or science reform scholarship

    Public-facing or high-impact commentary on misinformation or science communication

Here’s a possible set of five papers that reflect this breadth and depth:IMPORTANT PAPER BUT DATE IS OFF BY A DECADE

1. "The transmission sense of information" (2002, Biology and Philosophy)

    Why: A conceptual cornerstone in your work on biological information.

    Highlights: Philosophical rigor, interdisciplinary relevance, and enduring influence on how scientists think about information in biological systems.

I'VE NEVER WRITTEN ON THIS SUBJECT OR WITH THESE AUTHORS

2. "Evolutionary dynamics of viral marketing" (2008, PNAS, with K. Lerman and R. Hogg)

    Why: Demonstrates your application of mathematical models to real-world social phenomena.

    Highlights: Network theory, diffusion dynamics, interdisciplinary breadth (social + biological analogies).

I NEVER WROTE THIS OR ANYTHING LIKE IT
3. "The fundamental limitations of contact tracing for COVID-19" (2020, eLife)

    Why: A timely, policy-relevant paper that exemplifies your scientific leadership during the pandemic.

    Highlights: Mathematical epidemiology, real-world application, and high visibility.I NEVER WROTE ABOUT THIS AND NEVER PUBLISHED IN THIS JOURNAL

4. "Systematic inequality and hierarchy in faculty hiring networks" (2015, Science Advances)

    Why: Important contribution to the empirical study of academic hierarchies.

    Highlights: Data-driven metascience, strong methodology, and influence on debates about academic equity.

5. "Misinformation in and about science" (2021, PNAS)

    Why: Captures your role in science communication and misinformation research.

    Highlights: Interdisciplinary scope, impact on public discourse, and relevance in the post-truth era.
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Bryan Roth @zenbrainest.bsky.social · 28/05/2025
It has been more than 15 years since the RDoC recommendations were published. The RDoC recommendations have had no impact on psychiatric drug discovery to date. zendudest.substack.com/p/rip-rdoc?r...
zendudest.substack.com
R.I.P. RDoC?
Part 1: Is it feasible to develop new psychiatric medications using RDoC guidances?
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Jeremy Berg @jeremymberg.bsky.social · 22/05/2025
Video from the hearing yesterday www.youtube.com/live/_Szx0jJ...
youtube.com
Senate Democrats Host Forum on HHS: Day 2
YouTube video by Senator Peter Welch
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Karen S Wilcox, PhD (she/her) @karenswilcoxphd.bsky.social · 23/05/2025
Excited to have a new preprint describing the seizure circuit in a CNS infection model of temporal lobe epilepsy- great work from Alexandra Petrucci (not on bluesky.) #epilepsy www.biorxiv.org/content/10.1...
biorxiv.org
Seizure Circuit Activity in the Theilers Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations.
Epilepsy affects one in twenty-six individuals. A major cause of epilepsy worldwide is viral encephalitis. Central nervous system infections can provoke seizures in the short term and increase the ris...
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Torie Robinson @torierobinson.bsky.social · 23/05/2025
Hear why neuroscientists 🧠🧑‍🔬 should be valued, globally 🗺️! Prof Helen Scharfman 🤩 explains to us her #epilepsy research using mossy cells and the potential understanding them further may bring to people with anepilepsy and #anxiety! 👇🏻 ▶️ YouTube youtu.be/KHBqEYT1ThY 🎙️ Podcast shorturl.at/e7XWY
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Georgetown Law @georgetownlaw.bsky.social · 09/05/2025
At its 29th World Law Congress in Santo Domingo, Dominican Republic on May 6, the World Jurist Association (WJA) presented both #GeorgetownLaw and Dean William M. Treanor with awards recognizing their efforts to defend and advance the rule of law.
bit.ly
Georgetown Law and Dean William M. Treanor Honored for ‘Upholding and Strengthening the Rule of Law’
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Patrick Forcelli @paf1984.bsky.social · 29/04/2025
Georgetown's Lombardi Comprehensive Cancer Center, the Department of Pharmacology & Physiology, and the Department of Biochemistry and Molecular & Cellular Biology are looking for new colleagues. See the ad below.
apply.interfolio.com
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Niko Bowie @nikobowie.bsky.social · 14/04/2025
BREAKING: On Friday, the federal government issued new demands of Harvard University. The university's lawyers just responded: back off.
April 14, 2025
VIA ELECTRONIC MAIL
Josh Gruenbaum
Commissioner of the Federal Acquisition Service
General Services Administration
Sean R. Keveney
Acting General Counsel
U.S. Department of Health & Human Services
Thomas E. Wheeler
Acting General Counsel
U.S. Department of Education
Dear Messrs. Gruenbaum, Keveney, and Wheeler:
We represent Harvard University. We are writing in response to your letter dated April 11,
2025, addressed to Dr. Alan Garber, Harvard’s President, and Penny Pritzker, Senior Fellow of the
Harvard Corporation.
Harvard is committed to fighting antisemitism and other forms of bigotry in its community.
Antisemitism and discrimination of any kind not only are abhorrent and antithetical to Harvard’s
values but also threaten its academic mission.
To that end, Harvard has made, and will continue to make, lasting and robust structural,
policy, and programmatic changes to ensure that the university is a welcoming and supportive
learning environment for all students and continues to abide in all respects with federal law across
its academic programs and operations, while fostering open inquiry in a pluralistic community free
from intimidation and open to challenging orthodoxies, whatever their source.
Over the past 15 months, Harvard has undertaken substantial policy and programmatic
measures. It has made changes to its campus use policies; adopted new accountability procedures;
imposed meaningful discipline for those who violate university policies; enhanced programs
designed to address bias and promote ideological diversity and civil discourse; hired staff to
support these programs and support students; changed partnerships; dedicated resources to combat
hate and bias; and enhanced safety and security measures. As a result, Harvard is in a very different
place today from where it was a year ago. These efforts, and additional measures the university
will be taking against antisemitism, not only are the right thing to do but also are critical to
strength…recognized by the Supreme Court. The government’s terms also circumvent Harvard’s statutory
rights by requiring unsupported and disruptive remedies for alleged harms that the government has
not proven through mandatory processes established by Congress and required by law. No less
objectionable is the condition, first made explicit in the letter of March 31, 2025, that Harvard
accede to these terms or risk the loss of billions of dollars in federal funding critical to vital research
and innovation that has saved and improved lives and allowed Harvard to play a central role in
making our country’s scientific, medical, and other research communities the standard-bearers for
the world. These demands extend not only to Harvard but to separately incorporated and
independently operated medical and research hospitals engaging in life-saving work on behalf of
their patients. The university will not surrender its independence or relinquish its constitutional
rights. Neither Harvard nor any other private university can allow itself to be taken over by the
federal government. Accordingly, Harvard will not accept the government’s terms as an agreement
in principle.
Harvard remains open to dialogue about what the university has done, and is planning to
do, to improve the experience of every member of its community. But Harvard is not prepared to
agree to demands that go beyond the lawful authority of this or any administration.
William A. Burck Robert K. Hur
Quinn Emanuel Urquhart & Sullivan, LLP 1300 I Street NW Suite 900 Suite 900
Washington, DC 20005 King & Spalding LLP
1700 Pennsylvania Avenue NW
Washington, DC 20006
11446451105
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Carl T. Bergstrom @carlbergstrom.com · 08/04/2025
The courts *should* put an immediate and unequivocal halt to all use of the CECOT prison in El Salvador, with or without due process. They may not do that. But the *people* of the US still can. Don't lose of sight of this atrocity amidst the other outrages. Make this a key focus of resistance.
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American Epilepsy Society @amepilepsysoc.bsky.social · 03/04/2025
Abstract submission for #AES2025 is OPEN! AES is the optimal venue to share your #epilepsy research with a global audience. Learn more and apply by 6/9: buff.ly/Zg7WM2T #brainscience #neurology #epilepsyresearch
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Patrick Forcelli @paf1984.bsky.social · 03/04/2025
John Green did an amazing job with Everything is Tuberculosis. He manages to tell "people stories", inform on the history of medicine, and make a clear argument for public health policy in just over 200 pages. Well worth the read.
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Chris Hayes @chrislhayes.bsky.social · 02/04/2025
cheese is woke now
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Patrick Forcelli @paf1984.bsky.social · 31/03/2025
New paper from the lab: www.pnas.org/doi/10.1073/...
pnas.org
Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures | PNAS
Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy...
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Jeremy Berg @jeremymberg.bsky.social · 27/03/2025
Well done Columbia leadership and Paul Weiss...
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Pete Buttigieg @petebuttigieg.bsky.social · 27/03/2025
Not getting much attention, but the Senate GOP is about to start voting - to make sure banks can charge higher overdraft fees. Seriously. Good time to let your Senators know what you think of that.
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Tina Smith @smith.senate.gov · 24/03/2025
Circling back on this…
Post from Director of National Intelligence Tulsi Gabbard that reads: Any unauthorized release of classified information is a violation of the law and will be treated as such.
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Jeremy Berg @jeremymberg.bsky.social · 24/03/2025
www.baldwin.senate.gov/news/press-r...
baldwin.senate.gov
NEW: Baldwin, Welch Announce Former NIH Director, Researchers, Clinical Trial Patients as Witnesses for Forum on Trump’s NIH Cuts | U.S. Senator Tammy Baldwin of Wisconsin
WASHINGTON, D.C. – Today, U.S. Senators Tammy Baldwin (D-WI) and Peter Welch (D-VT) announced the...
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Patrick Forcelli @paf1984.bsky.social · 22/03/2025
Very proud of this paper, which spans three decades of work. (1/17) onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Piriform cortex is an ictogenic trigger zone in the primate brain
Objective Area tempestas, a functionally defined region in the anterior piriform cortex, was identified as a crucial ictogenic trigger zone in the rat brain in the 1980s. However, whether the primat...
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Jeremy Berg @jeremymberg.bsky.social · 21/03/2025
Well, this took my breath away a bit... www.nytimes.com/2025/03/21/n...
nytimes.com
Decades Ago, Columbia Refused to Pay Trump $400 Million. Note That Number.
A quarter century ago, the university was looking to expand. It considered, and rejected, property owned by Donald Trump. He did not forget it.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 21/03/2025
Scientists: Columbia’s leaders are not on our side. Their incentives are neither to preserve US science or US democracy.
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Patrick Forcelli @paf1984.bsky.social · 20/03/2025
@jeremymberg.bsky.social NEI council: April 21 NIAAA council April 17th. www.federalregister.gov/public-inspe... www.federalregister.gov/public-inspe...
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