Pedro Santamaria @p-santamaria.bsky.social · 13hWhile people believe in spirits, God, and Myths... www.lemonde.fr/sciences/art...lemonde.frA Paris, l’exposition « Magie, croire et savoir » met en lumière les mécanismes cognitifs qui se cachent derrière les illusionsMentalisme, lévitation, téléportation… Lors de cet événement conçu avec des compagnies de magie contemporaines, la Cité des sciences et de l’industrie invite les visiteurs à comprendre les raisons pou... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 15hWe could have bet on that ! And between researchers and teachers, the former would use AI less. www.nature.com/articles/d41...nature.comPhD students who write dissertation with AI less likely to stay in academiaUS PhD graduates who used artificial intelligence were more likely to work in industry. 000 0
Reposted by Pedro SantamariaMiles Huseyin @mileshuseyin.bsky.social · 15/10/2026(8/9) In the end, we concluded that there must be a component to Polycomb-mediated interactions that we don't know about yet. Given how they behave, we think something affinity-mediated is likely, but the mechanism remains an open question 131 3
Pedro Santamaria @p-santamaria.bsky.social · 16/10/2026I believe there's a misunderstanding somewhere. When cells lose their Identity, they have lost it ! It is identity (differentiation, Individual AND organ identity) that gives them their cellular bonds. The monozygotes twin girls A+B are just the same "culture". www.sciencealert.com/scientists-t...sciencealert.comScientists Trace How Cancer Passed Between Twins Before BirthA facial mass detected before birth prompted the early delivery of identical twin sisters. 000 0
Pedro Santamaria @p-santamaria.bsky.social · 16/10/2026- We all had to fight against that. - Positivity bias refers to the tendency to emphasize positive, statistically significant results over negative or null findings. - Linguistic bias refers to the use of optimistic or promotional language in research publications. www.science.org/doi/10.1126/...science.orgThe hidden cost of positivity: Ensuring integrity in scientific researchPositivity bias skews the scientific record by favoring positive results. Understanding the drivers and impact of such bias provides a foundation for creating solutions. 010 1
Pedro Santamaria @p-santamaria.bsky.social · 16/10/2026- At least he had started well, even though it was with leeches : ("I worked on homeobox genes that regulate body plan formation in leeches", said he). - Then he went astray, thinking he could cure individuals of the human species !! news.harvard.edu/gazette/stor...news.harvard.eduNobel laureate Karl Deisseroth’s time at HarvardHarvard graduate and new Nobel laureate reflects on his undergraduate years, early lab experiences, and his later work. 000 0
Pedro Santamaria @p-santamaria.bsky.social · 15/10/2026 "Within canonical Polycomb repressive complex 1 (cPRC1), polyhomeotic proteins are the primary contributors to interactions" !! 010 1
Pedro Santamaria @p-santamaria.bsky.social · 15/10/2026www.biorxiv.org/content/10.6...biorxiv.orgDissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactionsThe Polycomb system is an essential regulator of developmental genes which controls chromatin state through histone modifications and 3D chromatin organization. Although Polycomb-mediated histone modi... 120 2
Pedro Santamaria @p-santamaria.bsky.social · 15/10/2026" Il n’y a pas d’âge pour être idiot. Il n’y a pas d’âge pour confondre le souhaitable et le possible, pour tenir tout compromis pour une compromission, pour s’indigner et manifester. Il n’y a pas d’âge pour croire qu’on est courageux quand on est intransigeant". www.franc-tireur.fr/lfi-lage-bet...franc-tireur.frLFI, l’âge bête, l'édito de Raphaël EnthovenAux élections européennes, 33% des 18-24 ans ont voté pour LFI. Ce qui faisait 8 points d’avance sur le RN. Désormais, 42 % des jeunes... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 15/10/2026In a democracy, a (clearly noticeable !) pretentious, or presumptuous, Drama-King, who thinks he's a "Deus ex Machina", can still get elected.. anyway ! www.science.org/content/arti...science.orgTrump takes credit for a new ‘golden age’ of U.S. scienceIndustry heavyweights receive first national science medals awarded by the president 000 0
Pedro Santamaria @p-santamaria.bsky.social · 14/10/2026influence of Polycomb and Trithorax group function on the sexually dimorphic abdomen pigmentation of Drosophila melanogaster academic.oup.com/g3journal/ar...academic.oup.comThe influence of Polycomb and Trithorax group function on the sexually dimorphic abdomen pigmentation of Drosophila melanogasterAbstract. Animal traits develop through intricate patterns of gene expression that are regulated at multiple levels. This regulation includes interactions 010 1
Pedro Santamaria @p-santamaria.bsky.social · 14/10/2026Most of the time, that's how it goes. A good idea rescues it. Even great men are bad outside a specific (restricted) field. 100 1
Pedro Santamaria @p-santamaria.bsky.social · 14/10/2026www.irbbarcelona.org/en/news/scie...irbbarcelona.orgResearchers describe how a protein linked to cancer activates silent regions of DNAIn Ewing sarcoma, an abnormal protein formed by the fusion of two genes can activate repetitive DNA regions that normally remain silenced and turn them into gene regulatory elements. This mechanism co... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 14/10/2026They are Perverse ( Deliberately harmful ) because they believe in a "Higher Intelligence" as if they were talking about a God. But the concept of a God is a deviation into ill-informed pseudo-reasoning. gizmodo.com/a-guide-to-w...gizmodo.comA Guide to Which AI CEOs Now Say 'Super Intelligence' and Which Don'tWhich CEO has sunk the furthest into the putrid muck of Donald Trump’s decaying brain? 000 0
Pedro Santamaria @p-santamaria.bsky.social · 14/10/2026Who doesn't see that this buffoon, through his desire for inbreeding, is rather going to degenerate the nation ? www.nature.com/articles/d41...nature.comUS proposes $100,000 charge for international students to do postgraduate workSuggested change to immigration rules would choke off a crucial STEM talent pipeline, policy specialists say. 000 0
Pedro Santamaria @p-santamaria.bsky.social · 13/10/2026It's the same everywhere. It's not just a French thing. www.lemonde.fr/campus/artic...lemonde.fr« Etre une femme dans la recherche, c’est problématique. Etre une mère, plus encore » : le coût immense de la maternité pour les jeunes chercheuses« La recherche du temps perdu » (3/3). Une chercheuse sur trois quitte la recherche après avoir eu un enfant. Confrontées à une culture académique hostile à la maternité, certaines docteures repoussen... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 13/10/2026 Bertrand Russell propose une nouvelle forme de spiritualité et de sentiment religieux totalement affranchie des dogmes, des croyances théologiques et même de l'existence de Dieu. 010 1
Pedro Santamaria @p-santamaria.bsky.social · 13/10/2026When it comes to religion, even Canadians are less ridiculous than certain US states ! www.graphsaboutreligion.com/p/the-religi...graphsaboutreligion.comThe Religious Revival That Never CameTwenty years after a bold prediction, Canada's churches are still in decline. 000 0
Reposted by Pedro SantamariaLife Science Alliance @lsajournal.org · 12/10/2026A new piece of the Rho-ROCK signaling puzzle. This study reveals that the C-terminal PHC1 domain of ROCK1 helps recruit the kinase to active Rho signaling zones and contributes to transmitting Rho activity into cell contraction. @tu-dortmund.de www.life-science-alliance.org/content/9/12... 275 7
Pedro Santamaria @p-santamaria.bsky.social · 12/10/2026- Il est curieux comment on peut etre intelligente, honnête, juste, pondérée, et impartiale et Simultanément croire en Dieux créateurs, omniscients, omniprésents et issus des vieux peurs archaïques et absurdes créés par les hommes à l'époque où rien n'était compris. www.lemonde.fr/le-monde-des...lemonde.frDelphine Horvilleur, rabbine : « Après le 7-Octobre, il m’a fallu du temps pour parler de la souffrance des Palestiniens innocents »Trois ans après le 7-Octobre en Israël et le début de la guerre d’anéantissement contre Gaza, la rabbine revient, dans un entretien au « Monde », sur ce que ces drames ont provoqué en elle, dans la co... 000 0
Reposted by Pedro SantamariaTrends in Cancer @cp-trendscancer.bsky.social · 10/10/2026Enhancer of zeste homolog 2 links epigenetic plasticity to cholesterol metabolismdlvr.itEnhancer of zeste homolog 2 links epigenetic plasticity to cholesterol metabolismEnhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2), which mediates transcriptional repression. Kim and colleagues uncover a PRC2-independent EZH2-sterol regulatory element-binding protein 2 (SREBP2) axis that drives cholesterol biosynthesis, revealing an epigenetic-metabolic vulnerability exploitable through targeted protein degradation. 021 2
Pedro Santamaria @p-santamaria.bsky.social · 10/10/2026You can be a Tycoon and simultaneously a harmful and detrimental Simple-minded. The Antichrist is a archaic Myth. gizmodo.com/peter-thiel-...gizmodo.comPeter Thiel: You Know Who Else Wants to Regulate AI? The AntichristThiel's 'Antichrist' lecture series in Nashville is reportedly focused on casting AI regulation advocates as antichrist enablers. 000 0
Pedro Santamaria @p-santamaria.bsky.social · 09/10/2026That is how optogenetics discovery is applied !! 000 0
Pedro Santamaria @p-santamaria.bsky.social · 09/10/2026 "A l’heure actuelle, la déprise du catholicisme en France se poursuit". - The word: Déprise, mens to have less of a grip (less influence) on french people. - Which doesn't mean that people have become reasonable ! www.lemonde.fr/idees/articl...lemonde.frLa visite de Léon XIV en France ne peut faire oublier la déprise du catholicismeANALYSE. L’indéniable charisme du pape et la ferveur des fidèles qui l’ont suivi pendant quatre jours s’inscrivent dans un contexte de perte d’influence continue de l’Eglise, que ne compense pas l’aff... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 09/10/2026- Unlike Eclecticism ( to pick and mix various items loosely ), Syncretism blends them into something new. - Which religion is not, more or less, Syncretic with those that preceded it temporally or spatially ? - Therefore, all made by humans. www.mahj.org/fr/programme...mahj.orgConférence : L'aigle, le lion et la menorah. Traces d'un syncrétisme judéo-anatolien en Asie MineureConférence : Conférence de David Magueijo, auteur de L’aigle, le lion et la Ménorah. Approche socioculturelle de la diaspora juive d’Asie Mineure aux époques tardo-républicaine et impériale romaines (... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 08/10/2026Zut ! J'aurais aimé l'ouir ! Sûrement une belle perspective. 000 0
Reposted by Pedro SantamariaCSIC @csic.es · 08/10/2026🪵Un universo #neandertal de piedra y madera ⛏️Un trabajo de @iphes-cerca.bsky.social con personal de @mncn-csic.bsky.social analiza 597 restos de madera en el yacimiento del Abric Romaní 🔎Revelan el papel de este material en la vida cotidiana hace 40.000 años 👉https://f.mtr.cool/hg3phwfiw1 0148 14
Reposted by Pedro SantamariaHumanists International @humanists.bsky.social · 08/10/2026¡Disculpen que nos sumemos a la tendencia! ¿Qué clase de «medio» humanista eres tú? Humanists International es la organización global que agrupa a personas humanistas, ateas, laicistas y librepensadoras de todo el mundo, y que promueve los derechos humanos y los valores laicos en todas partes. 011 1
Pedro Santamaria @p-santamaria.bsky.social · 08/10/2026www.agenciasinc.es/Noticias/Un-...agenciasinc.esUn yacimiento español revela el dominio de la madera por parte de los neandertalesEste material se integraba en múltiples actividades de su vida cotidiana, con una tecnología diversa que incluía lanzas, herramientas, recipientes y elementos estructurales, además de un singular obje... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 08/10/2026"Analysis of wooden Neanderthal tools retrieved from Abric Romaní, an archaeological site (between 62,000 and 42,000 years ago) near Barcelona, Spain". - I have 2.5% of their DNA. And I'm not ashamed... "for sure". gizmodo.com/a-wooden-clu...gizmodo.comA Wooden Club and Other Rare Finds Reveal 'Invisible' Side of Neanderthal Life“Perhaps the simplest message is that the Palaeolithic was not a world made only of stone.” 100 1
Pedro Santamaria @p-santamaria.bsky.social · 08/10/2026- The young epigenome (... they mean DNA methylation) of Jonathan. - They compared his DNA methylation to five other DNA methylomes ranging in age between 5 and 91 years old, "his DNA methylome in some mitochondrial genes was as youthful as the 5-year-old’s". gizmodo.com/jonathan-the...gizmodo.comJonathan the Tortoise Has Survived 2 Centuries and a Fake Death. Now Scientists Are Unraveling His Anti-Aging SecretsScientists studied the genetics of the nearly 200-year-old giant tortoise. What they learned could some day help us extend our longevity. 000 0
Pedro Santamaria @p-santamaria.bsky.social · 07/10/2026www.biorxiv.org/content/10.6...biorxiv.orgPHC2-Dependent PRC1 Assemblies Stabilize Motor Neuron Hox CodesPolycomb Repressive Complexes PRC1 and PRC2 establish and maintain chromatin architectures critical for cell-type specific gene expression. In the developing spinal cord, PRC1 is essential for impleme... 000 0
Reposted by Pedro SantamariaPerrimon Lab @perrimonlab.bsky.social · 07/10/2026 FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs Yanhui Hu, et al bioRxiv 2026.09.28.755010; doi: doi.org/10.64898/202...doi.org 042 4
Reposted by Pedro SantamariaHumanists International @humanists.bsky.social · 07/10/2026Our advocacy team is once again hard at work at the UN Human Rights Council. In a statement, we called on States to repeal "blasphemy" laws and to make sure that reform of the UN system widens rather than narrows the space in which human rights defenders can be heard.humanists.internationalHumanists International calls for the repeal of "blasphemy" laws as UN experts warn of rising far-right extremismIn a statement to the general debate at the 63rd session of the UN Human Rights Council, Humanists International has asked States to count the non-religious among the human rights defenders targeted b... 031 3
Reposted by Pedro SantamariaTugce Aktas @aktast.bsky.social · 06/10/2026WT and mutant DNA methylation data clearly showed this ‘two-genome’ partition. Promoters of genes in the PRC1/2 program (GEP8) are hypo-methylated in E6.5 Epiblast; conversely, DNA/Chromatin/HUSH program (GEP37/29) gene promoters are strongly methylated. 111 1
Reposted by Pedro SantamariaTugce Aktas @aktast.bsky.social · 06/10/2026The power of this joint analysis was that it allowed us to build a cell state resolved genetic interaction map, where PRC-associated regulators are heavily focused on body axis genes, while lots of heterochromatin factors were focused on “junkier” parts of the genome. 121 2
Reposted by Pedro SantamariaTugce Aktas @aktast.bsky.social · 06/10/2026Our findings support the developmental hourglass model: late gastrulation is the most genomically and morphologically constrained period. Before this, suppressive epigenetic regulators silence repeats and evolutionary young genes, while PRC1/2 regulators safeguard cell-specific gene sets. 131 3
Reposted by Pedro SantamariaIva Tolić @ivatolic.bsky.social · 07/10/2026Optogenetics was our "remote control": light ON pulled the protein PRC1 off the mitotic spindle mid-division, light OFF brought it back. Without PRC1, the spindle changed shape and chromosomes struggled to line up. 122 2
Reposted by Pedro SantamariaGenetics Society of America @genetics-gsa.bsky.social · 06/10/2026🌟 Presenting the first essay in the “Notch and the Awesome Power of Genetics” series in #GENETICS Iva Greenwald shows how genetics remains essential in answering questions, even as the molecular events associated with Notch activation are elucidated in exquisite detail. 🔗 buff.ly/z4e5gT4 021 2
Reposted by Pedro SantamariaHumanists International @humanists.bsky.social · 06/10/2026En todo el mundo, el número de personas no religiosas crece constantemente. Se estima que hay 1,100 millones de personas sin afiliación religiosa, es decir, que se identifican como ateas, agnósticas o describen su religión como «ninguna en particular». 121 2
Pedro Santamaria @p-santamaria.bsky.social · 06/10/2026We concord in atheist... but the bay has the two names. As the paper said. Good thalasso and swimming ! 000 0
Pedro Santamaria @p-santamaria.bsky.social · 06/10/2026Bahía de Algeciras (Al-Jazira al-Khadra (الجزيرة الخضراء), Means Green Island. www.smithsonianmag.com/smart-news/i...smithsonianmag.comIn a Graveyard of Shipwrecks Between Europe and Africa, Archaeologists Discovered Vessels Doomed Over Thousands of YearsThe "harbor" of the Strait of Gibraltar is the final resting place for shipwrecks from ancient Rome, the medieval era and World War II, according to a new archaeological survey 110 1
Pedro Santamaria @p-santamaria.bsky.social · 06/10/2026The proof by the exemple ! www.smithsonianmag.com/smart-news/t...smithsonianmag.comTrio of Scientists Wins Medicine Nobel for a Method to Turn Nerve Cells On and Off With Light, Helping to Unravel the Brain's MysteriesKarl Deisseroth, Peter Hegemann and Georg Nagel received the 2026 award for their contributions to a revolutionary technique in neuroscience called optogenetics, which allows researchers to examine pr... 000 0
Pedro Santamaria @p-santamaria.bsky.social · 06/10/2026- Pure Scientific Research requires neither justification, profitability, nor application to humans ! - Now is the time to adapt this technique towards other cell types... and to forget about the hypothetical medical applications, brain’s roles and behaviours ! www.nature.com/articles/d41...nature.comMedicine Nobel awarded for brain ‘switch’ that controls neurons with lightKarl Deisseroth, Peter Hegemann and Georg Nagel win the 2026 Nobel Prize in Physiology or Medicine for their work on optogenetics, which has revolutionized neuroscience. 120 2