📄 PAPER HIGHLIGHT
Prostate cancer spreading to bone often resists immunotherapy. @petermaccc.bsky.social researchers have uncovered how these tumours hide from immune attack and identified a molecule (B7-H3) that could be targeted to fight back.
🔗 doi.org/10.1158/0008... @belindaparker.bsky.social
doi.org
Spatial Profiling Reveals Immune Escape Pathways and Therapeutic Vulnerabilities in Prostate Cancer Bone Metastases
AbstractProstate cancer frequently metastasizes to bone, marking incurable disease. This progression is driven by an immunologically cold bone tumor microenvironment that fosters resistance to therapy...