Historically reserved for refractory, end-stage eyes, conventional “pop-power titration” continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) effectively lowered intraocular pressure (IOP) through destruction of the ciliary body epithelium but carried a relatively high-risk profile, including prolonged inflammation, hypotony, phthisis, and vision loss.1 Over the past 2 decades, advancements and refinements in energy-delivery strategies have reshaped the role of TSCPC in glaucoma management.

Congenital cataract and uveitis caused by Spiroplasma ixodetis are rare, with only a small number of cases reported worldwide. We report 2 infants with unilateral uveitic congenital cataracts. Both underwent lensectomy and anterior vitrectomy, received intracameral antibiotics, and were postoperatively treated with a topical corticosteroid-antibiotic regimen. Routine microbiological tests were negative, but 16S rRNA PCR detected S. ixodetis in the vitreous and lens. Identification was confirmed by partial sequencing of the Mollicutes 16S-23S rRNA intergenic spacer region and a species-specific real-time PCR targeting rpoB gene of S.

The traditional priorities in retinoblastoma treatment are guided by a simple trinity: first, save the life; second, preserve the eye while not placing the child at undue risk; and third, preserve useful vision. Because globe-preserving therapy has become more effective, particularly with intra-arterial chemotherapy (IAC), we have appropriately moved toward attempting to save ever more advanced eyes.

The choroid is a densely vascular layer that sustains the outer retina and may reflect systemic microvascular health. With the advent of new imaging techniques, choroidal imaging has become increasingly detailed, generating vast data volumes. Conventional analytic tools often fall short in managing these high-dimensional datasets. Artificial intelligence (AI) automatically enhances, segments, and analyzes choroidal images, facilitating the discovery of choroidal biomarkers relevant to ocular and systemic disease.

Editor’s note: This is a developing news story. Please check back soon for updates. The FDA approved Brytly, a nonprescription eye drop for the relief of eye redness from minor irritations, according to a press release. Brytly (apraclonidine ophthalmic solution, 0.125%, Alcon) is approved for people aged 12 and older and is meant to be used no more than two times per day. Contact lenses should be removed prior to use, and users should wait at least 10 minutes after applying the drops before reinserting their contacts. Users should also wait 5 minutes before applying other eye drops. The

The FDA approved a supplemental new drug application for Ryzumvi, a preservative-free eye drop, for the treatment of presbyopia. “Presbyopia affects approximately 90% of Americans over age 45, making everyday activities like reading, using smartphones and working on computers increasingly difficult. Many patients rely on reading glasses or other corrective lenses, creating a significant need for convenient, noninvasive treatment options,” George Magrath, MD, MBA, MS, CEO of Opus Genetics, told Healio. “Phentolamine ophthalmic solution 0.75% offers a pharmacological alternative designed to

The FDA approved a supplemental new drug application for Ryzumvi, a preservative-free eye drop, for the treatment of presbyopia. “Presbyopia affects approximately 90% of Americans over age 45, making everyday activities like reading, using smartphones and working on computers increasingly difficult. Many patients rely on reading glasses or other corrective lenses, creating a significant need for convenient, noninvasive treatment options,” George Magrath, MD, MBA, MS, CEO of Opus Genetics, told Healio. “Phentolamine ophthalmic solution 0.75% offers a pharmacological alternative designed to

Editor’s note: This is a developing news story. Please check back soon for updates. The FDA approved Brytly, a nonprescription eye drop for the relief of eye redness from minor irritations, according to a press release. Brytly (apraclonidine ophthalmic solution, 0.125%, Alcon) is approved for people aged 12 and older and is meant to be used no more than two times per day. Contact lenses should be removed prior to use, and users should wait at least 10 minutes after applying the drops before reinserting their contacts. Users should also wait 5 minutes before applying other eye drops. The

Anti-VEGF injections before cataract surgery may protect eyes with retinal vein occlusion from developing postoperative macular edema, according to data published in BMC Ophthalmology. “Patients with [retinal vein occlusion] and concurrent cataract have been shown to benefit from cataract extraction to significantly improve visual outcomes,” Kevin Dahlan, MD, of the department of ophthalmology at Stony Brook University Hospital, and colleagues wrote. “However, [cataract extraction] poses challenges, as it significantly increases the risk of postoperative macular edema in

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Editor’s note: This is a developing story. Please check back soon for comments. The FDA approved Enspryng, an interleukin-6 inhibitor, for at-home subcutaneous treatment of thyroid eye disease, according to a press release from Genentech. The approval was supported by findings from the phase 3 SatraGO program in thyroid eye disease (TED). In patients with active and chronic moderate to severe TED, the SatraGO-2 trial demonstrated a “significant and clinically meaningful difference” of 52.9% in proptosis response and 60.7% in diplopia reduction with Enspryng vs. 23.4% and 25.8%, respectively, in

Editor’s note: This is a developing story. Please check back soon for comments. The FDA approved Enspryng, an interleukin-6 inhibitor, for at-home subcutaneous treatment of thyroid eye disease, according to a press release from Genentech. The approval was supported by findings from the phase 3 SatraGO program in thyroid eye disease (TED). In patients with active and chronic moderate to severe TED, the SatraGO-2 trial demonstrated a “significant and clinically meaningful difference” of 52.9% in proptosis response and 60.7% in diplopia reduction with Enspryng vs. 23.4% and 25.8%, respectively, in

To investigate the cross-sectional association between hypertension and OCTA-derived retinal microvascular characteristics.

En este estudio retrospectivo poblacional basado en datos del registro IRIS® (Intelligent Research in Sight), Ashourizadeh y otros (p. xxx) evaluaron la asociación entre la cirugía de cataratas (CS), y el riesgo de progresión de la degeneración macular asociada a la edad (dAMD) seca a AMD neovascular (nvAMD). El análisis de los 40.053 ojos incluidos en cada una de las cohortes, tanto la expuesta como la no expuesta, reveló que el CS se asociaba con un mayor riesgo de conversión de la dAMD a la nvAMD (relación de probabilidades: 1,22).

Eye, Published online: 15 October 2026; doi:10.1038/s41433-026-04934-yPersonalised ILM peeling for Myopic traction maculopathy

NEW ORLEANS — Oku Digital Health, which was recently launched from Topcon Healthcare, will use a network of more than 10,000 healthcare locations for early disease detection through routine eye exams, according to a press release. Oculomics is the use of ocular biomarkers to monitor for development of diseases. {{VIDEO}} At the American Academy of Ophthalmology meeting, Ali Tafreshi, CEO of Oku, told Healio that the company’s primary goal is to use this emerging field to address the healthcare cost crisis in the U.S. and globally. “We’ve been planting the seeds for what we call ‘healthcare from

NEW ORLEANS — Oku Digital Health, which was recently launched from Topcon Healthcare, will use a network of more than 10,000 healthcare locations for early disease detection through routine eye exams, according to a press release. Oculomics is the use of ocular biomarkers to monitor for development of diseases. {{VIDEO}} At the American Academy of Ophthalmology meeting, Ali Tafreshi, CEO of Oku, told Healio that the company’s primary goal is to use this emerging field to address the healthcare cost crisis in the U.S. and globally. “We’ve been planting the seeds for what we call ‘healthcare from

Faricimab showed a positive treatment effect for up to 6 months in patients with macular edema due to retinal vein occlusion, according to data published in Ophthalmology and Therapy. “Due to the very recent approval of faricimab for [macular edema] secondary to [retinal vein occlusion], and consequent restrictions on cost reimbursement by health systems, real-world data have been limited so far, and the first reports have only recently begun to emerge,” Katharina Heck, FMH, FEBO, of the Vista Augenklinik Binningen in Switzerland, and colleagues wrote. For a real-world look at

NEW ORLEANS — Verily Health has partnered with Bausch + Lomb to expand Verily Me, its consumer health app, into eye health for the first time. The launch adds personalized risk and symptom education, an AI-guided symptom conversation with AI agent “Vi,” and an overview of treatment options for dry eye disease. An estimated 150 million U.S. adults experience occasional or frequent dry eye symptoms, and about 38 million live with diagnosed dry eye disease. {{VIDEO}} “This is a disease that affects tens of millions of people, and there's a disconnect sometimes between what people are diagnosed with

NEW ORLEANS — Verily Health has partnered with Bausch + Lomb to expand Verily Me, its consumer health app, into eye health for the first time. The launch adds personalized risk and symptom education, an AI-guided symptom conversation with AI agent “Vi,” and an overview of treatment options for dry eye disease. An estimated 150 million U.S. adults experience occasional or frequent dry eye symptoms, and about 38 million live with diagnosed dry eye disease. {{VIDEO}} “This is a disease that affects tens of millions of people, and there's a disconnect sometimes between what people are diagnosed with

WHAT IS ALREADY KNOWN ON THIS TOPIC * Laser peripheral iridotomy (LPI) is an effective treatment for angle widening in primary angle closure disease, but whether the narrowest quadrant should be targeted remains uncertain.WHAT THIS STUDY ADDS * In primary angle closure suspect eyes from the Zhongshan Angle-Closure Progression Trial, superior LPI produced greater short-term angle widening than temporal or nasal LPI, and placement within the narrowest quadrant did not improve the anatomic response.HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY * LPI site selection should not rely on the narrowest sector alone; future studies should test whether superior placement translates into better long-term clinical outcomes.Introduction The spectrum of primary angle closure (sPAC) begins with primary angle closure suspects (PACS) and progresses to primary angle closure glaucoma (PACG), a disease associated with severe visual morbidity that contributes to more than 3.6 million cases of blindness worldwide.1–5

Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts.

This case report discusses a clinical diagnosis of Waardenburg syndrome type II in a woman aged 69 years who presented with bilateral iris and choroidal hypopigmentation and hyperpigmentation and a history of congenital deafness, iris heterochromia, and a gray hair patch since birth.

This case series examines the anatomical and functional phenotype of a variant in EFEMP1, p.Arg140Trp, and its associations with retinal degeneration.

This Special Communication reviews the distinct features of thyroid eye disease, the limitations of the currently available metrics, and introduces the Innovate TED Initiative to develop new outcome metrics.

A 31-year-old woman from Guam with no known medical history was referred by an ophthalmologist to a US cornea clinic for bilateral progressive blurred vision and corneal opacities. What would you do next?

This case report describes a diagnosis of lipemia retinalis in a woman aged 27 years with creamy discoloration of the retinal vessels on fundus examination and markedly elevated serum triglyceride levels.

Axial elongation is undoubtedly an important hallmark of myopia progression; however, it represents only a 1-dimensional measurement of a fundamentally 3-dimensional (3D) process involving changes in eye shape. Pathologic myopia in particular is characterized by ocular deformity, especially in the posterior segment.

Stargardt disease, which is the most common hereditary maculopathy, with a prevalence of at least 1 case in 10 000 persons, is a significant cause of visual morbidity and its numerous secondary consequences. Disease pathology begins with recessive variants in the gene ABCA4, which encodes a transmembrane protein localized to photoreceptor outer segments critical for transporting retinoid products of the visual cycle. Dysfunction of ABCA4 protein causes accumulation of A2E and other bisretinoids, collectively referred to as lipofuscin, and ultimately photoreceptor and retinal pigment epithelium degeneration. Visual acuity consequently declines to 20/200 or worse in the majority of affected individuals. Multiple efforts are underway to translate knowledge about the genetic basis and cellular pathophysiology of Stargardt disease into therapies, but there are currently no approved treatments.

This cohort study investigates if, among optical coherence tomography (OCT), OCT angiography, and visual field testing, one of these modalities detects glaucoma progression earlier than the others.

The TEASE-1 randomized clinical trial evaluates the safety and efficacy of oral gildeuretinol acetate on the growth of retinal atrophic lesions in individuals with Stargardt disease.

Patients taking adalimumab for autoimmune diseases who test positive for anti-adalimumab antibodies, and therefore lose the effectiveness of adalimumab, were more likely to also have comorbid ocular inflammation.

Click here to read the Healio Exclusive, “Expert panel examines myopia control spectacle lenses, pediatric imaging.” Pediatric progressive myopia is now treatable. Every eye doctor who sees children in their practice needs to be knowledgeable in this area as treatment options are expanding and improving. This is a field of special personal interest, and I disclose that I am active on the boards of directors and/or medical advisory boards for companies that target this treatment vertical. The incidence of pediatric progressive myopia (PPM) is growing worldwide. In the U.S. in 1980, when I started

Click here to read the Healio Exclusive, “Expert panel examines myopia control spectacle lenses, pediatric imaging.” Pediatric progressive myopia is now treatable. Every eye doctor who sees children in their practice needs to be knowledgeable in this area as treatment options are expanding and improving. This is a field of special personal interest, and I disclose that I am active on the boards of directors and/or medical advisory boards for companies that target this treatment vertical. The incidence of pediatric progressive myopia (PPM) is growing worldwide. In the U.S. in 1980, when I started

Publication date: Available online 14 October 2026 Source: AJO International Author(s): Kasem Seresirikachorn, Nattaporn Vongsa, Ta Chen Peter Chang

Publication date: Available online 15 October 2026 Source: Experimental Eye Research Author(s): Han-Ping Cheng, Lo-Jei Ching, Chia-Hao Wang, Muhammad Reza Putra Mahardhika, Huan Ou-Yang, Chun-Yuan Lee, Yuh-Lih Chang, Der-Chong Tsai, Chih-Chien Hsu, De-Kuang Hwang, Shih-Hwa Chiou, Shih-Jen Chen, Tai-Chi Lin, Yi-Ping Yang

An 8-year-old boy was found to have a right macular abnormality during routine screening. Best-corrected visual acuity was 20/20. Fundus photography showed 2 foveal reflexes (A). OCT angiography revealed an additional area of reduced capillary density temporal to the foveal avascular zone (B). Three-dimensional OCT reconstruction and the corresponding B-scan (C, bottom) showed an accessory depression adjacent to the primary fovea. Microperimetry showed fixation at the primary fovea, with measurable sensitivity near the temporal accessory depression (D).

Eye, Published online: 14 October 2026; doi:10.1038/s41433-026-04979-zSelf-administered intraocular injection of tattoo ink resulting in retinotoxicity and secondary glaucoma

To analyze the outcomes of an intravitreal methotrexate protocol in eyes that underwent complex retinal detachment (RD) repair for proliferative vitreoretinopathy (PVR).

To determine long-term visual and ocular outcomes in a large cohort of patients with choroidal melanoma treated using palladium-103 (103Pd) plaque brachytherapy.

Prediction marketplaces are taking their first steps into the pharmaceutical field — a move that some experts say may threaten the integrity of clinical trials. Prediction markets are platforms where users buy and sell shares on the future outcomes of events across a variety of subjects, like entertainment, sports, politics and technology. According to Matthew Vogel, MBA, a professor of health policy at Brown University, and colleagues, online prediction markets like Kalshi and Polymarket are introducing betting on drug development outcomes such as “whether POLARIS-AD, a phase 3 trial of the

Prediction marketplaces are taking their first steps into the pharmaceutical field — a move that some experts say may threaten the integrity of clinical trials. Prediction markets are platforms where users buy and sell shares on the future outcomes of events across a variety of subjects, like entertainment, sports, politics and technology. According to Matthew Vogel, MBA, a professor of health policy at Brown University, and colleagues, online prediction markets like Kalshi and Polymarket are introducing betting on drug development outcomes such as “whether POLARIS-AD, a phase 3 trial of the

A 35-year-old woman was referred by her optometrist for a neuro-ophthalmology evaluation for left optic disc edema and transient visual symptoms in the left eye. Her medical and ocular histories were notable for elevated BMI but were otherwise unremarkable. She was not taking any prescribed or over-the-counter medications at that time. Approximately 1 year before presentation, she began experiencing severe left retro-orbital pain that gradually decreased in severity over several months but otherwise remained. At the same time, she began experiencing intermittent, transient episodes of blurred

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