Sign in

Omar Ammar

@omarammar.bsky.social
113 followers 107 following 45 posts

C. Embryologist | TEDx speaker | #ESHREjc editor & @theESHRE5 | Alum @CheveningFCDO, @Dundeeuni, @UniofOxford | Views own

PostsRepliesMedia
Omar Ammar @omarammar.bsky.social · 05/07/2026
Amazing talk by Sofia Mackieva on ICSI vs IVF and rICSI! Early rescue ICSI (~8 hours) is better than late rescue ICSI! ESHRE SIG Embryology #eshre2026 @eshre.bsky.social
020
Omar Ammar @omarammar.bsky.social · 05/07/2026
Evidence (low certainty) supports the usage of 5% O2 for embryo culture as it increases clinical outcomes! Roger Sturmey ESHRE SIG Embryology #ESHRE2026 @eshre.bsky.social
000
Omar Ammar @omarammar.bsky.social · 29/05/2026
Will Implantation assessment eventually become a liquid biopsy? Exosomes, cfRNA, and miRNAs could detect abnormal receptivity or placentation before clinical manifestations? Strong biology. Still weak clinical validation. #eshrejc link.springer.com/article/10.1...
link.springer.com
Current knowledge on the role of extracellular vesicles in endometrial receptivity - European Journal of Medical Research
Endometrial receptivity has been widely understood as the capacity of the endometrium to receive implantable embryos. The establishment of endometrial receptivity involves multiple biological processe...
051
Omar Ammar @omarammar.bsky.social · 29/05/2026
evidence suggests decidualization defects may begin during the mid-luteal window, before implantation is clinically detectable, while most placental biomarkers only emerge later in the 1st trimester. mechanistic evidence exists for transcriptomic decidual signatures. gap is still huge. #eshrejc
051
Omar Ammar @omarammar.bsky.social · 29/05/2026
Strongest current signals: • HOXA10/11 • FOXO1 • IGFBP1 • PlGF/sFlt-1 Best evidence today: transcriptomics + angiogenic markers. Biggest gap: no validated predictive model for artificial/FET cycles. www.mdpi.com/1422-0067/25...
mdpi.com
000
Omar Ammar @omarammar.bsky.social · 29/05/2026
Totally agree! #eshrejc! What would you suggest as outcomes? How to assess?
131
Omar Ammar @omarammar.bsky.social · 29/05/2026
Q4-Which biomarkers, imaging approaches, or omics technologies could help identify impaired decidualization, abnormal implantation, or defective placentation in artificial cycles before clinical complications become evident? #ESHREjc
static.klipy.com
ALT:
563
Reposted by Omar Ammar
Mr.Att (Attilio Anastasi) @mr-att.bsky.social · 05/05/2026
🚨🚨🚨 Scientific Speed Dating returns to the #ESHRE Annual Meeting in London❗ 🚨🚨🚨 🌟 Meet experts and peers in reproductive medicine to exchange ideas, build connections, and discover new opportunities 🌟 First come, first served — don’t miss your chance to join 👉 lnkd.in/eVMhaDCf #ESHRE2026
223
Reposted by Omar Ammar
Mr.Att (Attilio Anastasi) @mr-att.bsky.social · 05/05/2026
@omarammar.bsky.social @mr-att.bsky.social @juanjo-fraire.bsky.social @noemisalmeri.bsky.social @dkalaitzopoulos.bsky.social Maíra Casalechi Julie LABROSSE #ESHRE
021
Reposted by Omar Ammar
Georges Raad, PhD @dr-georges-raad.bsky.social · 22/04/2026
Pleased to share that 7 abstracts have been accepted at #ESHRE2026, including 1 oral presentation. Looking forward to presenting and exchanging with colleagues in London this July. #eshre #ivf #infertility #ttc @omarammar.bsky.social @eshre.bsky.social
Pleased to share that 7 abstracts have been accepted at #ESHRE2026, including 1 oral presentation. Looking forward to presenting and exchanging with colleagues in London this July.
022
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 27/03/2026
@mr-att.bsky.socialwill be the lead moderator of this #ESHREjc – thank you Attilio, the floor is yours 😊
153
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 27/03/2026
Housekeeping essentials 👇 1. Use the hashtag #ESHREjc in all your posts 2. The #ESHREjc will take place over the weekend starting now until tomorrow 28 March 17.00 CET 🕔 3. Please always comment in the thread of the questions (they will be identified with Q1, Q2, …)
164
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 27/03/2026
We’d also like to welcome our experts @prof-lotti.bsky.social @smdsresearch.bsky.social @drdanielmarcu.bsky.social Monica Vazquez-Levin Luca Boeri #ESHREjc
184
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 27/03/2026
Welcome to this month's #ESHREjc moderators 🙌 Have fun! @mr-att.bsky.social @juanjo-fraire.bsky.social @gliperis.bsky.social @ribeirosara.bsky.social @dkalaitzopoulos.bsky.social @fabrizzio-horta.bsky.social @noemisalmeri.bsky.social @omarammar.bsky.social
174
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 31/01/2026
🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social And the # ESHREjc team 💫 Until next time! 👋🏻
277
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 31/01/2026
What have we been discussing during the #ESHREjc discussion on the oocyte cortex? Have a look at the summaries starting with q1 on its role in maturation 👇🏻
043
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 31/01/2026
Until next time! 👋🏻 @omarammar.bsky.social @mr-att.bsky.social @noemisalmeri.bsky.social @juanjo-fraire.bsky.social @dkalaitzopoulos.bsky.social @ribeirosara.bsky.social
063
Reposted by Omar Ammar
Noemi Salmeri, MD @noemisalmeri.bsky.social · 31/01/2026
Almost over for this session of the #ESHREjc ⏰ Summary for #Q2 👇🏼 @eshre.bsky.social
062
Omar Ammar @omarammar.bsky.social · 31/01/2026
Here’s the summary for Q1 on structural components of the oocyte cortex and GV to MII remodeling #ESHREJC @eshre.bsky.social
042
Omar Ammar @omarammar.bsky.social · 31/01/2026
Technically a bit difficult! From which follicular stage the testing should be initiated? From primordial? Or once we have more cumulus layers? #eshrejc
020
Omar Ammar @omarammar.bsky.social · 31/01/2026
To test cortical stiffness is easy and can be done before icsi for example. Measuring young’s modulus by poking the cortex. This could be then correlated with tissue stiffness and further development of the oocyte/embryo. #eshrejc
150
Reposted by Omar Ammar
Juan J. Fraire-Zamora @juanjo-fraire.bsky.social · 30/01/2026
Q3. Coticchio et al suggest cortical properties (stiffness, viscoelasticity) could be biomarkers of oocyte developmental competence. Which technologies 🧫🔬🤖could realistically be applied in an IVF lab 👩🏻‍🔬 to measure cortex mechanics and what are the major barriers to clinical 🧑🏻‍⚕️ translation? #ESHREjc
media.tenor.com
a circle with a blue wave in it
ALT: a circle with a blue wave in it
654
Reposted by Omar Ammar
Dimitrios Rafail Kalaitzopoulos @dkalaitzopoulos.bsky.social · 30/01/2026
Q4:Given that the cortex is a part of the interface between the oocyte and cumulus cells, how might abnormalities in the follicular environment alter cortical signaling or architecture, and how could these changes be detected through non-invasive follicular fluid or cumulus cell biomarkers? #ESHREjc
media.tenor.com
a card that says have an egg-stra egg-cellent day with a blue penguin
ALT: a card that says have an egg-stra egg-cellent day with a blue penguin
673
Omar Ammar @omarammar.bsky.social · 30/01/2026
In mouse, these fragments track poorer progression and lower blastocyst quality/cell number. In humans, fragmentation correlates with poorer prognosis, but the mechanistic link is still a gap. High scale perturbation/imaging is needed. #ESHREjc
051
Omar Ammar @omarammar.bsky.social · 30/01/2026
Data so far suggest embryo fragmentation can arise de novo during early cleavages: mitotic chromosome segregation problems keep DNA near the cortex long enough to trigger ectopic actomyosin contractions, essentially a misfired “polar body–like” response. #ESHREjc pubmed.ncbi.nlm.nih.gov/37427462/
pubmed.ncbi.nlm.nih.gov
Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway - PubMed
Cell fragmentation is commonly observed in human preimplantation embryos and is associated with poor prognosis during assisted reproductive technology (ART) procedures. However, the mechanisms leading to cell fragmentation remain largely unknown. Here, light sheet microscopy imaging of mouse embryos …
162
Reposted by Omar Ammar
Noemi Salmeri, MD @noemisalmeri.bsky.social · 30/01/2026
Q2: The paper proposed that cortical dysregulation can lead to blastomeri fragmentation and reduced blastocyst quality. What are the proposed mechanisms by which ectopic chromosomal signaling or cortical instability leads to abnormal cleavage patterns in early embryos? #ESHREjc
462
Omar Ammar @omarammar.bsky.social · 30/01/2026
What’s your preferred readout of this switch in human oocytes: PB2 kinetics, PN centration, or cortex stiffness? #eshrejc
030
Omar Ammar @omarammar.bsky.social · 30/01/2026
Exactly and the testable point is causality: chromatin proximity breaks symmetry (Cdc42/Ran cues), Arp2/3 builds the polar domain, and spatially restricted myosin-II then converts that polarity into mechanics (spindle rotation + PB extrusion) #ESHREjc
140
Omar Ammar @omarammar.bsky.social · 30/01/2026
chromatin→cortex axis is likely multi-step: chromatin proximity builds a Ran-GTP/Cdc42 polarity cue, and Fyn may gate/amplify local outputs. Downstream suspects include Cdc42–N/WASP→Arp2/3, formins (mDia), pERM, and myosin-II via MRCK/ROCK. #ESHREjc
150
Omar Ammar @omarammar.bsky.social · 30/01/2026
Mouse gives mechanistic resolution, but human validation is essential given cortical thickness/stiffness differences. Key question is whether the logic (polarity modules + spatially distinct myosin pools) is conserved, even if parameters shift. Any human time-lapse/biomech data? #eshrejc
050
Omar Ammar @omarammar.bsky.social · 30/01/2026
Myosin-II in the oocyte cortex isn’t a one thing. distinct cortical pools (eg, a polarized ring vs the cytokinetic furrow) are wired to different upstream kinases. So “myosin inhibition” can uncouple polarity from mechanics, giving distinct maturation phenotypes. #ESHREjc
030
Omar Ammar @omarammar.bsky.social · 30/01/2026
Yes, distinct phenotypes make sense cuz Arp2/3 and myosin-II sit in different control layers. Arp2/3 shapes cortical architecture + actin flows that establish/maintain polarity and cap organization, while myosin-II executes stage-specific force generation needed for rotation/cytokinesis. #eshrejc
040
Omar Ammar @omarammar.bsky.social · 30/01/2026
Yes, distinct phenotypes make sense cuz Arp2/3 and myosin-II sit in different control layers. Arp2/3 shapes cortical architecture + actin flows that establish/maintain polarity and cap organization, while myosin-II executes stage-specific force generation needed for rotation/cytokinesis. #eshrejc
140
Omar Ammar @omarammar.bsky.social · 30/01/2026
Internet issue not a skill issue 😭🤣 #eshrejc
150
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 30/01/2026
The discussion is open for the next 24h until 17:00 CET tomorrow Saturday Join the discussion 💫
media.tenor.com
Run GIF
ALT: Run GIF
021
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 30/01/2026
Housekeeping rules Always use the #ESHREjc for all relevant discussion points
media.tenor.com
a cartoon of spongebob holding a vacuum cleaner
ALT: a cartoon of spongebob holding a vacuum cleaner
131
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 30/01/2026
The discussion will be moderated by the #ESHREjc team: @juanjo-fraire.bsky.social @omarammar.bsky.social @noemisalmeri.bsky.social @ribeirosara.bsky.social @mr-att.bsky.social @dkalaitzopoulos.bsky.social @fabrizzio-horta.bsky.social
153
Omar Ammar @omarammar.bsky.social · 30/01/2026
Q1. How do the structural components of the oocyte cortex (e.g., actin, myosin-!, pERM, Arp2/3, Fyn kinases) dynamically remodel during the transitions from GV to MIl and how do these changes mechanistically support spindle positioning and polar body extrusion? #ESHREjc
media.tenor.com
a picture of a woman with the words i 'm just an egg
ALT: a picture of a woman with the words i 'm just an egg
553
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 30/01/2026
Housekeeping essentials 👇 1. Use the hashtag #ESHREjc in all your posts 2. The #ESHREjc will take place over the weekend starting now until tomorrow 31 January 17.00 CET 🕔 3. Please always comment in the thread of the questions (they will be identified with Q1, Q2, …)
164
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 30/01/2026
Welcome to this month's #ESHREjc moderators 🙌 Have fun! @gliperis.bsky.social @noemisalmeri.bsky.social @omarammar.bsky.social @mr-att.bsky.social @juanjo-fraire.bsky.social @dkalaitzopoulos.bsky.social @ribeirosara.bsky.social @fabrizzio-horta.bsky.social
195
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 30/01/2026
For those who have not had the chance to read the paper our moderators have created a great Skytorial 👉 bsky.app/profile/glip... #ESHREjc
164
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 30/01/2026
Welcome everyone, we are back for the 51st edition of the #ESHREjc and the very first one on Bluesky! 🙌 🦋
155
Reposted by Omar Ammar
ESHRE @eshre.bsky.social · 30/01/2026
This edition’s paper is “The emerging role of the oocyte cortical domain in maturation, fertilization, and development” published in our academic journal Human Reproduction 👩‍🎓 🔗 doi.org/10.1093/humr... #ESHREjc
doi.org
The emerging role of the oocyte cortical domain in maturation, fertilization, and development
Abstract. The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent i
164
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 23/01/2026
🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer 
To find out join #ESHREjc on Friday 29/1 starting 17:00 CET. @paolavigano.bsky.social @rvassena.bsky.social @enricabianchi.bsky.social&authors Giovanni Cotichio and Danilo Cimadomo Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/ 🧵 #bluetorial 👇🏻
pubmed.ncbi.nlm.nih.gov
The emerging role of the oocyte cortical domain in maturation, fertilization, and development - PubMed
The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent in mammalian oocytes. As in other cells, the cortex ensures appropriate shape and robustness of oocytes. It is also involved in other key and more specific …
187
Reposted by Omar Ammar
gliperis.bsky.social @gliperis.bsky.social · 05/01/2026
🚨 The #ESHRE journal club is now on Bluesky! Is the oocyte cortex the hidden key to egg quality, fertilisation, and embryo development? Join us for the next #ESHREjc 🗓 30–31 January ⏰ 17:00 CET start-stop academic.oup.com/humrep/artic... Experts 👉🏻 RitaVassena @paolavigano.bsky.social
2159
Omar Ammar @omarammar.bsky.social · 01/12/2025
Welcome @eshre.bsky.social Let’s revive the good old days of science communication here!!
020
Omar Ammar @omarammar.bsky.social · 07/11/2025
Dear connections, any expert I have here that has good understanding of the current drought situation of Tigris river in Iraq? Science and geopolitics wise. I wanna do a short interview for my instagram.
010
Omar Ammar @omarammar.bsky.social · 07/06/2025
Whatever you’re offering as an in intervention whether big or small in the MAR world if it doesn’t tick one of these then it’s unnecessary especially if it comes with a fee to pay. Ticking these requires evidence not a claim.
000
Omar Ammar @omarammar.bsky.social · 02/05/2025
Thanks
000
Omar Ammar @omarammar.bsky.social · 01/05/2025
Hi everyone, anyone aware of universities accepting researchers to do PhDs by publications (retrospective)? @academic-chatter.bsky.social
321