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gliperis.bsky.social @gliperis.bsky.social · 29/05/2026

Question 4 on emerging technologies to identify patient populations at risk #ESHREjc 👇🏻

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Noemi Salmeri, MD @noemisalmeri.bsky.social · 29/05/2026

You proposed N-of-1 trials in RIF (I have loved it)... Could a similar precision-medicine framework help identify the small subgroup of patients with true luteal insufficiency, assuming we can first define it? #ESHREjc academic.oup.com/humrep/artic...

academic.oup.com

Challenges ahead: catalyzing research for the 2% prevalence of repeated implantation failure

Sir,

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filiparafael.bsky.social @filiparafael.bsky.social · 29/05/2026

Yes, this is a biologically plausible hypothesis. In AC, the absence of a corpus luteum may affect vasoactive and angiogenic pathways involved in implantation and early placentation. This could contribute to the higher risk of hypertensive disorders and adverse perinatal outcomes observed #ESHREJC

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hmelzeiny.bsky.social @hmelzeiny.bsky.social · 29/05/2026

#ESHREjc The CL is far more than a progesterone pump. Beyond P4, it secretes relaxin, VEGF, oestrogen metabolites, prostaglandins, prorenin, and 5α-dihydroprogesterone — none of which are replaced in artificial cycles. Each has a distinct role at the implantation window 👇

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lainas1.bsky.social @lainas1.bsky.social · 29/05/2026

Interesting wrinkle #ESHREjc: AC shows more HDP & LGA, but SGA, preterm & birthweight are null — closer to an endometrial-metabolic phenotype than placental insufficiency? However, worth holding lightly given the obstetric data were partly incomplete. Curious how others read it.

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gliperis.bsky.social @gliperis.bsky.social · 29/05/2026

Question 3 of the #ESHREjc discussion on clinical direction in light of the findings 👇🏻

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Rita Vassena @rvassena.bsky.social · 29/05/2026

Also sperm, yes. It is hypothesized that it is caused by the lack of seminal plasma (in donor semen) and full non-self nature of the embryo (in donor oocytes). Of note, the effect seems cumulative, with double donation risk > oocyte > semen. #ESHREjc

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julie-labrosse.bsky.social @julie-labrosse.bsky.social · 29/05/2026

In addition to progesterone, the corpus luteum secretes relaxin and angiogenic substances that play a role in implantation and placentation #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 29/05/2026

Question 2 of the #ESHREjc discussion on safety 👇🏻 Join the discussion

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Rita Vassena @rvassena.bsky.social · 29/05/2026

In any case, these results are in line with the recently published RCT in the @bmj.com where only ovulatory women were included, and again NC came out better: #ESHREjc www.bmj.com/content/392/...

bmj.com

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Rita Vassena @rvassena.bsky.social · 29/05/2026

Or, a reviewer-in-me comment (recognized by authors): the two clinical approaches (NC and AC) are not fully interchangeable; so recipient are not all from one population. if not addressed, may affect the conclusions. Would have ❤️ a subanalysis w/ only regular menstrual cycles. #ESHREjc

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Paola Viganò @paolavigano.bsky.social · 29/05/2026

Relaxin seems to be the most interesting as it behaves almost like a “system-wide remodeling signal” rather than a narrowly targeted reproductive hormone.#ESHREjc

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Noemi Salmeri, MD @noemisalmeri.bsky.social · 29/05/2026

Studies that supports a corpus luteum hypothesis, usually do not actually measure any corpus luteum-derived factors….Are we observing an association or demonstrating a mechanism? Curious to know what you think @rvassena.bsky.social #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 29/05/2026

Q1: Beyond progesterone itself, which corpus luteum-derived factors may play a key role in implantation, placentation, and obstetrical outcomes after FET? #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 29/05/2026

This month the topic of discussion is endometrial preparation. Have a look at the #tweetorial below about the discussed paper 👇🏻

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Noemi Salmeri, MD @noemisalmeri.bsky.social · 25/05/2026

Can natural cycles be effectively utilized in women of advanced maternal age undergoing oocyte donation? 👀 To explore the answer, join the next #ESHREjc 📍May 29th, 17:00 CET 👉Featured paper: academic.oup.com/humrep/advan... Short summary (what we call “skytorial” or “bluettorial”) provided below👇

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gliperis.bsky.social @gliperis.bsky.social · 28/04/2026

🎉 Scientific Speed Dating returns at #ESHRE2026 in London! 🎉 👩🏼‍🔬 Junior professionals don’t miss this chance to connect with leading experts. 💡 Exchange ideas, spark collaborations, & discover new opportunities. 👥 Secure your spot ! Co-organised by the #ESHREjc & Young Talent Group #ESHRE

lnkd.in

This link will take you to a page that’s not on LinkedIn

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gliperis.bsky.social @gliperis.bsky.social · 27/03/2026

Q1: If severe male-factor infertility impairs fertilization and embryo development but not neonatal outcomes among live births, how should this change clinical counselling and treatment strategy? #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 27/03/2026

The important role of male in treatment outcomes will be discussed in this #ESHREjc edition!

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gliperis.bsky.social @gliperis.bsky.social · 27/03/2026

If you would like to join use the #ESHREjc hashtag

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gliperis.bsky.social @gliperis.bsky.social · 26/03/2026

Join the #ESRHEjc for an important topic! 💫

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social And the # ESHREjc team 💫 Until next time! 👋🏻

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

Question 3 summary of usable clinical markers from the discussion 👇🏻 #ESHREjc

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Juan J. Fraire-Zamora @juanjo-fraire.bsky.social · 31/01/2026

Here the summary of our discussion for Q3 on biomechanic parameters of oocyte developmental competence #ESHREjc @eshre.bsky.social

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

On question 2 of the #ESHREjc here the summary of the discussion on the role of the oocyte cortex in downstream embryo development 👇🏻

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

What have we been discussing during the #ESHREjc discussion on the oocyte cortex? Have a look at the summaries starting with q1 on its role in maturation 👇🏻

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

Follicular markers can be indicative but face practical difficulties in clinical settings 👇🏻 #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

Could we find ways to predict oocyte survival post egg freezing cycles? This would be a game changer in counselling for patients undergoing egg freezing for fertility preservation and social reasons #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 31/01/2026

How does the follicular environment might affect 👇🏻#ESHREjc

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Rita Vassena @rvassena.bsky.social · 31/01/2026

On this, I am team pipette. It's not invasive, positioning by the embryologist and automated measure (think of the automated blood pressure band on the arm). The question is, as always, one of sensitivity and sensibility, still very much to be tested. #ESHREjc

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Paola Viganò @paolavigano.bsky.social · 30/01/2026

We have to assume that trancriptomic profile is able to quantify/reflect mechanical forces. #ESHREjc

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Juan J. Fraire-Zamora @juanjo-fraire.bsky.social · 30/01/2026

In the fruit fly embryos, mechanical forces modulate the expression of some genes 😎 we would need to look in humans. Maybe blastoids could help?! #ESHREjc www.cell.com/fulltext/S15... Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

cell.com

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

Mechanical deformations associated with embryonic morphogenetic movements have been suggested to actively participate in the signaling cascades regulating developmental gene expression. Here we develo...

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Paola Viganò @paolavigano.bsky.social · 30/01/2026

Impressive that this paper on characterization of the injection funnel during ICSI has 10 years....new findings can revive older evidence.#ESHREjc

sciencedirect.com

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Juan J. Fraire-Zamora @juanjo-fraire.bsky.social · 30/01/2026

At the moment, data available finds a difference in biomechanical parameters that can lead to embryo viability and live birth. But the cause of this abnormal parameters will be difficult to adress #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 30/01/2026

Question 4 on cortex effects on paracrine interactions #ESHREjc 👇🏻

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Mr.Att (Attilio Anastasi) @mr-att.bsky.social · 30/01/2026

2/2 Major barriers to clinical 🧑🏻‍⚕️ translation remain throughput, operator dependency, lack of standardization, and crucially proving added predictive value beyond existing morphological and morphokinetic markers. 🚨🚨🚨 #ESHREjc

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Mr.Att (Attilio Anastasi) @mr-att.bsky.social · 30/01/2026

Building on Coticchio et al., cortical mechanics as biomarkers is not entirely speculative. For example, Yanez et al. (PNAS, 2016) showed that oocyte stiffness measured by AFM correlates with meiotic competence and spindle integrity. #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 30/01/2026

Question 3 on clinical markers of cortical activity is now live. Join the #ESHREjc discussion 👇🏻

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gliperis.bsky.social @gliperis.bsky.social · 30/01/2026

Data from emerging optical microscopy approaches needed 📣 #ESHREjc

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gliperis.bsky.social @gliperis.bsky.social · 30/01/2026

Multilayered control 🪖⛑️🧢👇🏻 #ESHREjc

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Paola Viganò @paolavigano.bsky.social · 30/01/2026

Fyn-null oocytes have problems in maintaining cortical integrity....they are subfertile #ESHREjc

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Mr.Att (Attilio Anastasi) @mr-att.bsky.social · 30/01/2026

Studying ectopic chromosomal signaling that misactivates RhoA–myosin II at the cortex is fundamental to understanding this key mechanism underlying abnormal cleavage and fragmentation. #ESHREjc

media.tenor.com

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gliperis.bsky.social @gliperis.bsky.social · 30/01/2026

The effects of cortical dysregulation in embryo development are discussed in the 2nd question of the #ESHREjc 👇🏻

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Paola Viganò @paolavigano.bsky.social · 30/01/2026

Appropriate stiffness due to acto-myosin network is crucial for splindle positioning and PB extrusion. #ESHREjc

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