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María Olmedo

@olmedo-lab.bsky.social
129 followers 150 following 8 posts
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Reposted by María Olmedo
PLOS Biology @plosbiology.org · 28/07/2026
#Development requires precise temporal coordination of cellular programs. This study by @olmedo-lab.bsky.social reveals how reduced insulin signaling in C. elegans slows down cell division to realign developmental timing before the next molt. 🧪#AcademicSky plos.io/4g17uiv
Diagram of the events of the molting process and seam cell divisions during larval development, with indication of the events monitored in the study. Images of a worm are below, showing the body structure and seam cells, labeled in green.
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
Science moves forward through collaboration. This study would not have been possible without the fantastic collaboration between the @unisevilla.us.es, Jeroen van Zon @amolf-nl.bsky.social , and @marthamerrow.bsky.social @lmu.de. Thank you to all co-authors and collaborators (6/6)
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
Our results suggest that larval stages behave as modular developmental units, with a compensatory mechanism that prevents timing defects from propagating during development. (5/6)
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
The duration of the L2lag correlates with the extent to which seam cell divisions occur after ecdysis, linking developmental desynchrony with stage delay. Experimentally advancing or delaying seam cell divisions shortens or extends the lag, supporting a causal relationship. (4/6)
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
We identify a previously unrecognized "L2lag" phase that appears at the beginning of larval stages and is particularly prominent in daf-2 mutants. Reduced insulin signaling delays both molting and cell divisions, but divisions are affected more strongly, generating developmental desynchrony. (3/6)
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
We uncover a developmental buffering mechanism in C. elegans: when seam cell divisions lag behind molting, larvae delay the onset of the next stage, restoring synchrony between developmental events. (2/6)
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María Olmedo @olmedo-lab.bsky.social · 27/07/2026
Our latest research is published in @plosbiology.org Development is not just about keeping time—it is also about correcting timing errors. (1/6) journals.plos.org/plosbiology/...
journals.plos.org
A desynchrony mechanism between events triggers a compensatory delay during Caenorhabditis elegans development
Development requires precise temporal coordination of parallel cellular programs, such as molting and cell division in C elegans larvae. This study shows reduced insulin signaling delays both of proce...
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Reposted by María Olmedo
Daphne Cabianca @daphne-cabianca.bsky.social · 30/04/2026
My lab is looking for a PhD student 🔥 Starting date: flexible - end of 2026/beginning of 2027 👉 Are you interested in understanding how diet, metabolism and the environment shape cell and organismal function through chromatin and nuclear organisation? Read more 👇
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Reposted by María Olmedo
EMBO @embo.org · 12/01/2026
Registration and abstract submission deadlines extended until 6 February for the EMBO | The Company of Biologists Workshop "𝘊. 𝘦𝘭𝘦𝘨𝘢𝘯𝘴 Biology" in Merida, México, 24–28 February 2026. meetings.embo.org/event/26-worm #EMBOWorms2026 #Celegans #conference #meeting #EMBOevents 🧪
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María Olmedo @olmedo-lab.bsky.social · 06/01/2026
You can find the article here: www.nature.com/articles/s41...
nature.com
Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth - Nature Communications
Insulin-mediated FOXO nuclear translocation is a key step in the stress response. Here, the authors show that C. elegans DAF-16/FOXO translocates in stochastic pulses. These pulses are synchronized th...
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María Olmedo @olmedo-lab.bsky.social · 06/01/2026
Our latest work in collaboration with the group of Jeroen van Zon. The transcription factor DAF-16/FOXO moves in and out of the nucleus in a strikingly synchronous manner across cells, regulating organismal growth. www.linkedin.com/posts/amolf_...
linkedin.com
Rhythm contains important information for the cell | AMOLF
😊 AMOLF kicks off the new year with a fascinating rhythm 😊 Together with collaborators, C. elegans researchers in the group of Jeroen van Zon discovered that the insulin-driven protein DAF-16 does no...
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Reposted by María Olmedo
Savage-Dunn lab @cswormlab.bsky.social · 14/02/2025
Community is more valuable than ever - submit an abstract and attend #Worm25 !
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Reposted by María Olmedo
Margarete Diaz Cuadros @mdiazcuadros.bsky.social · 20/12/2024
Can't miss opportunity for anyone interested in developmental timing!! See you in Paris⏳️
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Reposted by María Olmedo
Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · 27/01/2025
Join us this coming May 6-9 in Paris for the second EMBO Meeting on developmental timing across species. Registration now OPEN. Stellar line-up of inv. speakers + talks selected from abstracts. meetings.embo.org/event/25-dev... @trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social
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Reposted by María Olmedo
MicroClock ERCSyG @microclockerc.bsky.social · 05/11/2024
The first ERC Synergy grant for chronobiology has been awarded to Microclock to investigate the Bacillus subtilis circadian clock. MicroClock is a collaboration between Martha Merrow, Antony Dodd and Akos T Kovacs #LMU_Muenchen #JohnInnesCentre #UniLeiden #ERC_Research #ERCSyG
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Reposted by María Olmedo
The Hassan Brain Development Team @hassanbraindevlab.bsky.social · 01/12/2024
Second edition of the EMBO workshop on Developmental Timing across species. Second edition organized by @trayon.bsky.social @bassemh.bsky.social @vanderhaeghenp2.bsky.social and Margerete Diaz-Cuadros Cool speakers & fun networking activities. More details coming soon.Save the date: May 6-9 2025!
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