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Omid S. Alavijeh

@oalavijeh.bsky.social
76 followers 181 following 20 posts

Currently: Honorary Consultant Nephrologist and Lecturer in Renal Medicine @ UCL Recent: MRC Doctoral and AstraZeneca/MRC fellow Academic kidney doctor #bioinformatics #genomics #popgen Profile: profiles.ucl.ac.uk/60145-omid-sadeg…

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Reposted by Omid S. Alavijeh
Konrad @konradjk.bsky.social · 13/05/2026
🧬 New preprint! We present an All by All analysis in All of Us: common and rare variant association testing across 392,030 whole genomes and 3,602 phenotypes. 1.337 trillion tests, ~50k significant signals, all publicly browseable. www.medrxiv.org/content/10.6...
medrxiv.org
Systematic common and rare variant association testing in 392,030 whole genomes in All of Us
Large-scale genome-wide association studies (GWAS) and rare variant association studies (RVAS) from population biobanks provide valuable resources for gene discovery in complex human traits. We presen...
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Omid S. Alavijeh @oalavijeh.bsky.social · 16/01/2026
🚀 Applications are open for the @acmedsci.bsky.social Starter Grants! As a previous awardee, the funding helped me do some cool science in ADPKD. I would highly recommend applying! 🗓️ Apply by 26 Feb 👉 acmedsci.flexigrant.com/startapplica...
acmedsci.flexigrant.com
Login - Academy of Medical Sciences
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Reposted by Omid S. Alavijeh
Kidney Precision Medicine Project @kpmproject.bsky.social · 03/06/2025
Explore the KPMP Kidney Tissue Atlas today 🔍 Search markers 🧬Download raw gene data 🗺️Explore spatial data Openly accessible and designed to support discovery 🔗 atlas.kpmp.org #KPMP #KidneyResearch #OpenScience #KidneyTissueAtlas
atlas.kpmp.org
Explorer
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Omid S. Alavijeh @oalavijeh.bsky.social · 30/11/2025
Thanks @thesampsonlab.bsky.social for the lovely write up!
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Reposted by Omid S. Alavijeh
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/11/2025
OK thread of all simulpubs at this year's #KidneyWk ORIGIN-3: Atacicept pubmed.ncbi.nlm.nih.gov/41196369/ CKD as a curable dz? www.kidney-international.org/article/S008... Albuminuria as a surrogate endpoint www.nature.com/articles/s41...
pubmed.ncbi.nlm.nih.gov
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy - PubMed
In this prespecified interim analysis, treatment with atacicept resulted in a significantly greater reduction in proteinuria than placebo at week 36 in patients with IgA nephropathy. (Funded by Vera Therapeutics; ORIGIN 3 ClinicalTrials.gov number, NCT04716231.).
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Reposted by Omid S. Alavijeh
Nephrology Journal Club @nephjc.bsky.social · 27/10/2025
⏩ Next #NephJC is on IgA nephropathy @kdigo.org guideline 🎨 Nice visual summary by @roxnonna23.bsky.social www.nephjc.com/news/2025/10...
nephjc.com
KDIGO 2025 IgA guidelines - Visual Abstract — NephJC
KDIGO 2025 is here. IgAN management is evolving with precision risk tools, new therapies, and a stronger focus on kidney protection. Check out the visual abstract created by Natalia Nombera
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Reposted by Omid S. Alavijeh
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/10/2025
Obinituzumab aka ‘Obi’ is now FDA approved for lupus nephritis finance.yahoo.com/news/fda-app... #lupus
finance.yahoo.com
FDA Approves Genentech’s Gazyva for the Treatment of Lupus Nephritis
SOUTH SAN FRANCISCO, Calif., October 20, 2025--Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today that the U.S. Food and Drug Administration (FDA) has approved Gazyva...
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Reposted by Omid S. Alavijeh
ASN Publications @asnpublications.bsky.social · 13/10/2025
In a new "Mechanisms of Kidney Disease" article in #ASNJASN, authors explore population studies and the genetic architecture of kidney diseases, highlighting a spectrum of risk. Read more: kidney.pub/JASN0893 @dannygale.bsky.social
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Reposted by Omid S. Alavijeh
Danny Gale @dannygale.bsky.social · 02/10/2025
If you’re interested in learning about all things genetic in nephrology, come to our Renal Genomics course in London, 5-6 March 2026!
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Omid S. Alavijeh @oalavijeh.bsky.social · 28/09/2025
This will be fantastic (not just because I am helping to organise it)! An amazing line up of speakers and topics. Hope to see you there!
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Omid S. Alavijeh @oalavijeh.bsky.social · 28/09/2025
🚨 New paper alert 🚨 Proud to share our work in AJKD: “Quantifying APOL1, HLA, and other genetic contributions to unexplained kidney failure” What drives kidney failure when the cause is unknown? 🧵 www.ajkd.org/article/S027...
ajkd.org
Quantifying APOL1, Human Leukocyte Antigen, and Other Genetic Contributions to Unexplained Kidney Failure
Unexplained kidney failure (uKF) affects 15% of individuals needing kidney replacement therapy. The lack of a clear diagnosis creates uncertainty about recurrence, familial risk, and trial eligibility...
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Reposted by Omid S. Alavijeh
Dominique Guerrot @dguerrot.bsky.social · 06/08/2025
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
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Reposted by Omid S. Alavijeh
Nature Portfolio @natureportfolio.nature.com · 24/08/2025
A paper in Nature reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation. go.nature.com/415CMhr 🧬 🧪
This is figure 1, which shows the variant call sets.
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Omid S. Alavijeh @oalavijeh.bsky.social · 28/07/2025
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Reposted by Omid S. Alavijeh
Mike Inouye @mikeinouye.bsky.social · 05/06/2025
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
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Omid S. Alavijeh @oalavijeh.bsky.social · 02/04/2025
📘 What could nephrology look like in 2050? This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care: shorturl.at/A18zK
shorturl.at
The future of nephrology in 2050
As medicine advances at an unprecedented pace, the field of nephrology is poised for transformative change. By 2050, breakthroughs in kidney disease p…
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