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Noa Matosevich

@nmatosevich.bsky.social

25 followers 28 following 8 posts

Neuroscientist, doing my PhD @labnir.bsky.social || Interested in sleep, the LC and norepinephrine.

Posts Replies Media

Noa Matosevich @nmatosevich.bsky.social · 11/09/2025

Thanks Jonas! PdCO was great to work with ☺️

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Noa Matosevich @nmatosevich.bsky.social · 10/09/2025

My PhD paper is finally out! 🎉 We show how specific LC pathways shape sound-evoked awakening, revealing LC heterogeneity in action. So grateful to all the amazing people who made this possible 🙌

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Reposted by Noa Matosevich

Jonas Wietek @jwietek.bsky.social · 12/02/2025

AAV1 hSyn-PdCO-mScarlet-WPRE is finally available from @addgene.bsky.social 🧪🧠 All resources here: docs.google.com/spreadsheets...

docs.google.com

PdCO resources

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

In conclusion, we found LC heterogeneity in the context of sleep and arousal. More specifically, our work reveals a specific pathway critical to sound evoked awakenings.

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

Finally, selective synaptic silencing using an optoGPCR, PdCO, demonstrated that silencing LC synapses in the PRN is sufficient in elevating sigma power in EEG during NREM sleep.

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

Optoactivation of LC neurons projecting to each of our target regions showed that the influence of LC fast activation on sound evoked awakenings depended both on the population identity (only the LC-PRN) and on the precise timing in synchronicity with sounds.

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

NE monitoring in these targets during sleep and while playing sounds revealed a unique fast NE surge in the PRN in response to sounds. Importantly, this fast surge determined whether the sounds would awaken the mice.

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

Comparing two LC pathways- to the basal forebrain and to the brainstem PRN, we found that LC neurons projecting to the two regions were partially distinct anatomically.

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Noa Matosevich @nmatosevich.bsky.social · 03/02/2025

Excited to share our new preprint out on biorxiv! We found a specific LC pathway that influences sensory evoked awakenings from NREM sleep. @labnir.bsky.social #bluespot 🔵 www.biorxiv.org/content/10.1...

biorxiv.org

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sen...

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