Objective Prescribing advice recommends higher doses of allopurinol in tophaceous gout "to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels". The aim of…

A treat-to-target strategy was associated with improved long-term disease control compared with symptom-driven care, without evidence of increased adverse events. These findings provide support for…

Physical therapy is routinely recommended for knee pain attributed to a degenerative meniscal tear, but its efficacy has not been established. We randomly assigned participants 45 to 85 years of ag...

A new analysis suggests that chondrocalcinosis is a cause, rather than just a consequence, of knee osteoarthritis.

Urate crystals alone are required but not sufficient to trigger gout flares; they can also be modulated by environmental, metabolic, genetic and epigenetic factors. Avoiding large variation in urate l...

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Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis...

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Nature Reviews Rheumatology, Published online: 23 April 2025; doi:10.1038/s41584-025-01255-4Urate crystals alone are required but not sufficient to trigger gout flares; they can also be modulated by environmental, metabolic, genetic and epigenetic factors. Avoiding large variation in urate levels, maintaining prophylaxis until crystal clearance and initiating low-dose urate-lowering therapy are efficient strategies for disease management.

Nature Reviews Rheumatology - In this Review, the authors provide an overview of gout and hyperuricaemia in Indigenous peoples of the Pacific region, including discussion of genetic, clinical and...

Sadly, in 2024, Rheumatology lost many of our greatest brethren, mentors, do-gooders and clinicians. These clinicians were responsible for the care of hundreds of thousands with MSK problems, while…