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Nicholas Gervais

@nickgervais.bsky.social
139 followers 126 following 4 posts

PhD candidate developing CRISPR-based technologies to study pathogenic fungi 🧬🇨🇦

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Reposted by Nicholas Gervais
Ana Flores-Mireles @afloresmireles.bsky.social · 20/07/2026
Ever wonder how fungal infections take hold in the bladder? 🔬. Our new research sheds light on fungal virulence in human and mouse models during catheterization! alabella14.bsky.social, @nickgervais.bsky.social, @felipehst.bsky.social, @shapirorebecca.bsky.social www.pnas.org/doi/10.1073/...
pnas.org
The unique Efg1 fungal virulence regulon in the catheterized bladder environment | PNAS
Urinary catheterization, a frequent procedure in hospitals, nursing homes, and other healthcare facilities, is a primary driver of nosocomial infec...
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Reposted by Nicholas Gervais
Rebecca Shapiro @shapirorebecca.bsky.social · 12/05/2026
It's been a long time coming to finally see this in print! While not the first paper from my lab, it is one of the very first projects we started working on from day 1 links.springernature.com/f/a/1IP7gCfA...
links.springernature.com
Pooled CRISPRi screening reveals fungal-specific drug target candidates - Nature Microbiology
This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner...
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College of Biological Science @uofgcbs.bsky.social · 23/04/2026
Antifungal resistance isn’t just about one gene.🧬 Researchers led by PhD student Nick Gervais & @shapirorebecca.bsky.social have developed a new CRISPR tool that can control multiple genes at once in fungal pathogens. SCRIBE🗞️: www.uoguelph.ca/cbs/news/202... @uofgresearch.bsky.social
Dish with cultured c. albicansNick Gervais in the lab
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Reposted by Nicholas Gervais
Felipe H Santiago-Tirado @felipehst.bsky.social · 11/11/2025
Preprint alert: the latest from my collaboration with the great @afloresmireles.bsky.social, @shapirorebecca.bsky.social , and Ilse Jacobsen (not in BS). You can find it here: www.biorxiv.org/content/10.1... A small thread below (1/3)
biorxiv.org
The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment
Urinary catheterization, a common procedure in hospitals and nursing home facilities, is a primary driver of hospital-acquired infections (HAI). These devices frequently lead to catheter-associated ur...
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Reposted by Nicholas Gervais
Rebecca Drummond 🍄 @therad-lab.bsky.social · 19/03/2025
Excellent news - we desperately need more antifungal drugs. Onto the reading list this goes! #microsky 🧪
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Reposted by Nicholas Gervais
Oded Rechavi @odedrechavi.bsky.social · 17/03/2025
Since both believed to some extent in inheritance of acquired traits, the fundamental difference between Lamarck and Darwin (aside from mechanism, natural selection vs use and disuse) is that Lamarck believed in the power of Life and Darwin believed in the power of Death
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Craig MacLean @craigmaclean.bsky.social · 24/01/2025
New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time. www.biorxiv.org/content/10.1...
biorxiv.org
Chromosomal capture of beneficial genes drives plasmids towards ecological redundancy
Plasmids are a ubiquitous feature of bacterial genomes, but the evolutionary forces driving genes to become associated with plasmids are poorly understood. To address this problem, we compared the fit...
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Reposted by Nicholas Gervais
Viktoria Cologna @colognaviktoria.bsky.social · 20/01/2025
Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳 With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5
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Nicholas Gervais @nickgervais.bsky.social · 15/01/2025
This is great. Hope this format makes its way to other Nature journals (and can be open-access...)
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Reposted by Nicholas Gervais
Erik van Nimwegen @erikvannimwegen.bsky.social · 15/01/2025
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients
It is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p...
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Reposted by Nicholas Gervais
Hans Carolus @hanscarolus.bsky.social · 10/01/2025
When I started my PhD 6 years ago, this sticker on my office door got me excited. Sure! let's "CRISPR Candida auris"! Today I am excited to show that that's not as easy as it sounds! 😉 Read our latest preprint on the challenges with editing C. auris: www.biorxiv.org/content/10.1...
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Hiten Madhani @hitenmadhani.bsky.social · 07/01/2025
Happy New Year, blue-sci-peeps! My piece in Annual Review of Biophysics on chromatin replication is now available online. doi.org/10.1146/annu... If you have paywall issues, try this link: madhanilab.ucsf.edu/s/annurev-bi...
doi.org
Mechanisms of Inheritance of Chromatin States: From Yeast to Human | Annual Reviews
In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG methylation can be faith...
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Neville Sanjana @nevillesanjana.bsky.social · 26/12/2024
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄 In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
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Reposted by Nicholas Gervais
Itai Yanai @itaiyanai.bsky.social · 20/12/2024
Can't wait for this new meeting on drug resistance and tolerance across species and diseases. A principle revealed in one system – maybe using different terminology – could be the big new idea when imported to another! Abstract deadline in January! s.embl.org/ees25-01 @EMBO/@embl.org
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