This research describes new mechanisms linking the locus coeruleus to deep sleep and reveals differences according to sex and cerebral vascular status.

INTRODUCTION Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus ...

INTRODUCTION The Down syndrome-associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association Internation.....

Objectives Frontotemporal dementia (FTD) usually shows more asymmetric atrophy patterns than Alzheimer’s disease (AD). We aim to quantify this asymmetry to differentiate FTD, AD, and FTD subtypes. Met...

Early-onset degeneration of hyperactive locus coeruleus axons in the olfactory bulb drives olfactory dysfunction in Alzheimer’s disease via phosphatidylserine-MFG-E8 signaling and microglial clearance...

ISTAART Neuromodulatory Subcortical Systems PIA: Tiny Dots - Noradrenergic Axon Loss Drives Hyposmia in AD - 21st January, 5.30pm GMT