Antiplatelet agents target the cyclooxygenase-1 (COX-1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)-P2Y12 (cytochrome P450 2C19 [CYP2C19]-metabolized) platelet activation pathways, resultin....

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Earlier variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), including the original strain, Alpha and Delta, were linked to significant and persistent cognitive impairment. The l...

Serum elemental profiling combined with machine learning supports exploratory Alzheimer's disease (AD) identification and cognitive score prediction. In this retrospective cross-sectional study, 874 ...

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The figure illustrates the potential of targeting glial cell functions and their interactions with neurons as a therapeutic strategy for neurodegeneration.

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Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential....

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Glutamate dysregulation leads to neurological disorders, which has prompted a paradigm shift towards neuroprotection targeting ionotropic glutamate receptors (iGluRs). Neurons may be less susceptible....

Long COVID continues to affect millions, with symptoms that mirror those of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This research highlight reveals that both conditions share comm...

Diagrammatic representation of the effect of pre-eclampsia on postpartum stroke severity. e7, gestational day 7; ePE, experimental pre-eclampsia; NormP, normal pregnancy; PP, postpartum; tMCAO, trans...

Pre-eclampsia (PE), a hypertensive disorder during pregnancy, impairs maternal endothelial function, leading to inflammation and oxidative stress that may increase the risk of severe brain conditions ...

Mechanistic crosstalk between microglia and astrocytes in major depressive disorder.