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Nathan Insel

@networksunknown.bsky.social
231 followers 371 following 74 posts

Exploring social neuroscience and animal behavior. Based in Kitchener-Waterloo, Ontario

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Nathan Insel @networksunknown.bsky.social · 01/07/2026
Expired mystery
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Nathan Insel @networksunknown.bsky.social · 19/06/2026
Wow! What happened next? (Not a caption) Send more and we'll diplomat to estimate the perceived safety radius of each animal :)
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Nathan Insel @networksunknown.bsky.social · 02/03/2026
New neuroscience job at Wilfrid Laurier University. You may not know the name, but science has been growing fast. It is also down the street from Canada's top tech university (Waterloo) and a world class physics institute (Perimeter). I feel happy and lucky to be here careers.wlu.ca/job/Waterloo...
careers.wlu.ca
Assistant Professor - Psychology (Behavioural Neuroscience)
Assistant Professor - Psychology (Behavioural Neuroscience)
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Nathan Insel @networksunknown.bsky.social · 12/02/2026
Nice!
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Nathan Insel @networksunknown.bsky.social · 27/01/2026
Or is she transcendendate
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Nathan Insel @networksunknown.bsky.social · 12/01/2026
If the purpose of analysis is to test hypotheses, then model should come first. If the purpose is to make new observations (to inform models), then after. But neuro tends to be pretty bad at separating the two, and stats or model fits sometimes become tautologies
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Nathan Insel @networksunknown.bsky.social · 04/01/2026
There are many pitfalls and challenges. Nachum discusses this in the book, and one chapter is about technological developments that make it more feasible (this is also why @wheelerlab.org and I put some years into developing DIPLOMAT). But he also describes so many ways it has paid off
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Nathan Insel @networksunknown.bsky.social · 04/01/2026
I realized it's because I cared about how brains deal with layers of uncertainty by forming and updating many levels of expectations. And a good way to get uncertainty, along with the behavioral agency to address it, is letting animals behave freely in dynamic, uncontrolled environments.
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Nathan Insel @networksunknown.bsky.social · 04/01/2026
Personal note: when I started my own lab I had a small crisis: why study extremely complex brains when we still don't understand how simpler brains do the same things?
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Nathan Insel @networksunknown.bsky.social · 04/01/2026
The back-and-forth between "control all variables" and "observe systems as they naturally occur" is probably as old as science. Nachum explains so many reasons, with so many elegant examples, why systems neuroscience needs a diversity and balance of approaches.
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Nathan Insel @networksunknown.bsky.social · 04/01/2026
One of the best books I read in 2025 was Nachum Ulanovsky's _Natural Neuroscience_. If my copy looks a little worn, it's because I was intent on reading it in natural habitats.
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Nathan Insel @networksunknown.bsky.social · 29/12/2025
www.nature.com/articles/s41...
nature.com
Generative AI creates synthetic regulatory DNA sequences for precision gene control - Nature Genetics
We developed DNA-Diffusion, a generative artificial intelligence (AI) method that creates synthetic regulatory elements showing enhanced activity. Multiple synthetic elements demonstrated superior cel...
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Nathan Insel @networksunknown.bsky.social · 11/12/2025
A non-scientist friend saw your name in this article and used your quote to counter something I had previously said. She says thank you.
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Reposted by Nathan Insel
Harry Wallop @harrywallop.co.uk · 02/12/2025
Great culture can save lives. Literally. Amazing letter in today’s @thetimes.com about Tom Stoppard
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Nathan Insel @networksunknown.bsky.social · 21/10/2025
On the Nobel Prize winner, Camillo Golgi (from Cani and Mazzarello, 2016)
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Nathan Insel @networksunknown.bsky.social · 16/10/2025
Seller's profile pic:
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Nathan Insel @networksunknown.bsky.social · 24/09/2025
Amazing! Congratulations!
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Nathan Insel @networksunknown.bsky.social · 02/09/2025
There are certainly other good solutions to multi-animal tracking that DIPLOMAT does not yet implement--like finding visual differences between animals. All code is open source (github.com/TravisWheele...) and these features could be easily incoporated or used alongside the algorithms packaged here.
github.com
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Nathan Insel @networksunknown.bsky.social · 02/09/2025
How it works: instead of finding body parts within frames and then knitting these across frames, DIPLOMAT applies a hidden Markov model (Viterbi algorithm) that traces body parts through a video. We use the same movement and skeletal information as other tools, but as HMM transition probabilities.
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Nathan Insel @networksunknown.bsky.social · 02/09/2025
Perhaps most useful is that DIPLOMAT is designed to make manual edits much more efficient: multiple body parts can be corrected with a single click and, once corrected, re-traced across frames.
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Nathan Insel @networksunknown.bsky.social · 02/09/2025
With DIPLOMAT, you can still use models trained in DeepLabCut or SLEAP! But the algorithms also improve tracking (fewer body-swaps, better recall and precision)--even when body parts are occluded.
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Nathan Insel @networksunknown.bsky.social · 02/09/2025
New preprint: There are some decent tools for multi-animal tracking, but it can still be difficult to track interacting animals without mixing them up. Isaac Robinson (with @wheelerlab.org and others) have developed a software solution that we are now using full time: doi.org/10.1101/2025...
doi.org
DIPLOMAT: multi-animal tracking with efficient manual editing
Recent advances in computer vision have enabled the development of automated animal behavior observation tools. Several software packages currently exist for concurrently tracking pose in multiple ani...
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Nathan Insel @networksunknown.bsky.social · 24/08/2025
More biomed in Canada
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Nathan Insel @networksunknown.bsky.social · 22/06/2025
"Emotion" vs "affective state" sounds like a fun example of how psychological constructs are clustered hierarchically. Would be interested if anyone takes this up in an articulate and compelling way.
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Nathan Insel @networksunknown.bsky.social · 22/06/2025
Not an expert, but I take this issue up in my intro neuro course. We walk through ~8 definitions and examine where they fail. We then put these together into our own, including "usual" causes (perceived valence) and "typical" consequences (visceral, also facial/vocal expressions).
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Nathan Insel @networksunknown.bsky.social · 04/06/2025
New strategy for grant and paper rejections
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Nathan Insel @networksunknown.bsky.social · 02/06/2025
Notable paper on sleep aid lemborexant (putting aside caveats of mouse models of Alzheimer's). I have collected 2 1/2 years of data on myself and can confirm even small (2 mg) doses add sleep hours. www.nature.com/articles/s41...
nature.com
Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy - Nature Neuroscience
Parhizkar et al. show that lemborexant, an orexin receptor antagonist, protects against neurodegeneration in male tau transgenic mice by preventing tau protein build-up and inflammation, highlighting ...
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Nathan Insel @networksunknown.bsky.social · 31/05/2025
Thanks for this! On writing: I remember Tulving saying that he admired and was inspired by Hartline's paper on lateral inhibition for its writing. From all the written history about Tulving and his influences, this isn't something one might easily guess.
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Nathan Insel @networksunknown.bsky.social · 27/05/2025
Oh so now we are in a parasocial friendship?
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Nathan Insel @networksunknown.bsky.social · 27/05/2025
Cool!
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Nathan Insel @networksunknown.bsky.social · 14/05/2025
Didn't catch that, thank you. Will add "toothpaste related crime" to the landscape of imagined futures
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Nathan Insel @networksunknown.bsky.social · 14/05/2025
Earnest question: can't kids get their fluoride by regularly eating a small amount of their toothpaste?
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Nathan Insel @networksunknown.bsky.social · 03/05/2025
To borrow from Alan Moore "Uglier than death backin' outta the outhouse readin' mad magazine and crazy as a football bat."
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Nathan Insel @networksunknown.bsky.social · 09/04/2025
Awesome!! (Incidentally, one of my favorite topics! journals.plos.org/ploscompbiol... pmc.ncbi.nlm.nih.gov/articles/PMC... )
pmc.ncbi.nlm.nih.gov
Differential Activation of Fast-Spiking and Regular-Firing Neuron Populations During Movement and Reward in the Dorsal Medial Frontal Cortex
The medial prefrontal cortex is thought to be important for guiding behavior according to an animal's expectations. Efforts to decode the region have focused not only on the question of what informati...
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Reposted by Nathan Insel
Tristan A.F. Long @thelonglab.bsky.social · 26/03/2025
My university is accepting applications for the Visiting Researcher - Scholars at Risk Program, established to support scholars who are facing threats to their life, liberty or academic career, &/or have been forced to leave their academic position because of such threats. www.wlu.ca/academics/re...
wlu.ca
Visiting Researcher-Scholars at Risk | Wilfrid Laurier University
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Nathan Insel @networksunknown.bsky.social · 06/03/2025
I did that. Cured the boredom. Aged twice as fast but tripled life meaning--overall win.
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Nathan Insel @networksunknown.bsky.social · 19/01/2025
I appreciate the debates about machine intelligence, and how LLMs are forcing us to review our constructs. But I also think it's fun to think of LLMs as a mirror we've put in front of animals that don't have a concept of mirrors (image from @theonion.com)
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Nathan Insel @networksunknown.bsky.social · 09/01/2025
My 12 yo after I told him that "datum" is singular for data: "Once my generation gets into the Miriam-Webster office, there are going to be a lot of changes"
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Nathan Insel @networksunknown.bsky.social · 09/01/2025
www.cell.com/cell/abstrac...
cell.com
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.
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Reposted by Nathan Insel
Marlene Cohen @marlenecohen.bsky.social · 04/01/2025
New results for a new year! “Linking neural population formatting to function” describes our modern take on an old question: how can we understand the contribution of a brain area to behavior? www.biorxiv.org/content/10.1... 🧠👩🏻‍🔬🧪🧵 #neuroskyence 1/
biorxiv.org
Linking neural population formatting to function
Animals capable of complex behaviors tend to have more distinct brain areas than simpler organisms, and artificial networks that perform many tasks tend to self-organize into modules (1-3). This sugge...
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Nathan Insel @networksunknown.bsky.social · 18/12/2024
I enjoyed this, thank you! Also speaks to Bluesky's "love-to-hate Musk" audience: "Instead of the bundle of Neuralink electrodes, Musk could just use a telephone, whose data rate has been designed to match human language, which in turn is matched to the speed of perception and cognition."
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Nathan Insel @networksunknown.bsky.social · 03/12/2024
An indubitably indelible individual
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Nathan Insel @networksunknown.bsky.social · 03/12/2024
You got me to read this 23(?) years ago. The part I remember, and cite with some regularity, is how the character deals with freezing-up in public bathrooms. A well articulated "animal social cognition" phenomenon.
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Nathan Insel @networksunknown.bsky.social · 20/11/2024
I think this is it! Or some minor twists on it. Thank you so much for the link--and thinking about/publishing this in the first place! It captures a very deep question of how mind/subjective state depends on the specific casual interactions within the mechanisms.
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Nathan Insel @networksunknown.bsky.social · 20/11/2024
@jaanaru.bsky.social : maybe you know where I can find this?
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Nathan Insel @networksunknown.bsky.social · 20/11/2024
@neuroai.bsky.social : years ago you tweeted about a thought expmnt that toyed with whether a conscious system depends on connections (like "lab records brain, also stimulates unconnected cells in synchrony w/recording--is the collection of cells conscious?") Do you know where this is published?
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Nathan Insel @networksunknown.bsky.social · 12/09/2024
Authors should initially be in randomized order, with some "false authors" included. Then at the end of the paper we find out who the fake authors were ("I never would have guessed!") and who were the first and senior/corresponding authors ("wow, I thought he was dead").
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Nathan Insel @networksunknown.bsky.social · 12/09/2024
To encourage readers beyond the abstract, it should also end with exciting leads, e.g., "You won't believe what the mice did next" or "Stay tuned for the big reveal in Discussion"
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Nathan Insel @networksunknown.bsky.social · 12/09/2024
Journal article abstracts should include "<SPOILER ALERT>" immediately before the results of the study are revealed.
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Nathan Insel @networksunknown.bsky.social · 02/01/2024
This hurts my brain. But I've also had a long term dependence on ATP
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