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In ER-positive, HER2-negative advanced breast cancer, giredestrant, an ER degrader and full ER antagonist, plus everolimus led to longer progression-free survival than standard endocrine therapy–everolimus; safety was similar. Full phase 3 evERA Breast Cancer trial results: nej.md/47ryfbF

A graph from an Original Article published in the New England Journal of Medicine article titled "Giredestrant plus Everolimus in Advanced Breast Cancer." The graph shows progression-free survival among patients with ESR1-mutated tumors. The trial name, evERA Breast Cancer, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 2h

Figure 5 from a Clinical Problem-Solving feature shows the physiologic function of tissue-nonspecific isoenzyme of alkaline phosphatase. Read more about it in “Break a Leg” by M. Wijnen et al.: nej.md/4zOIkwu

An illustrated diagram from the Clinical Problem-Solving "Break a Leg." The top section is labeled "Physiologic Function of Tissue-Nonspecific Isoenzyme of Alkaline Phosphatase (TNSALP)." The bottom section is labeled "Effects of TNSALP Deficiency in Hypophosphatasia."

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NEJM.org @nejm.org · 6h

Psychedelics are on the FDA’s mind (Politico) nej.md/4ya29MR Sounding Board: FDA’s New Framework for Psychedelic Drugs nej.md/3UIOpuh

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NEJM.org @nejm.org · 6h

A New Drug Lifts the Fog of Sleepiness for Those With Narcolepsy (The New York Times) nej.md/4jsD4ZA Original Article: Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials nej.md/4gvhEZZ

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NEJM.org @nejm.org · 6h

Scientists discover new tick-borne virus after testing thousands of patients with mysterious illnesses (FOX News) nej.md/4ykESIP Correspondence: A Zoonotic Orthonairovirus from Febrile Patients in China nej.md/4zPPws9

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NEJM.org @nejm.org · 8h

Current therapies for narcolepsy type 1 do not target orexin deficiency or treat all symptoms. Oveporexton, an oral orexin receptor 2−selective agonist, has shown efficacy in a phase 2 trial. Research findings from two phase 3 trials are summarized in a new Quick Take video. nej.md/4AsoBTE

Illustration of oveporexton for narcolepsy type 1. A brain is shown with an arrow pointing from a highlighted area to a person sleeping on a desk beside a laptop.

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NEJM.org @nejm.org · 29/09/2026

In the phase 3 TRIUMPH-1 trial involving patients with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events. Full trial results: nej.md/4ycgSHz

A graph from an Original Article published in the New England Journal of Medicine article titled "Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity." The graph shows effect of retatrutide on body weight. The trial name, TRIUMPH-1, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 29/09/2026

The authors of a new article review the ways in which polygenic risk scores, along with the related field of pharmacogenomics, may be useful in clinical practice for the prevention and treatment of common diseases. Read the full article: nej.md/4Amwv0F

A bullet list of key points from the Review Article "Clinical Uses of Common Genetic Variants Associated with Common Diseases" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

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NEJM.org @nejm.org · 29/09/2026

Oya virus, an orthobunyavirus, was identified in a 54-year-old woman who had sepsis-like symptoms, including leukocytosis, thrombocytopenia, elevated liver-function values, and disseminated intravascular coagulation. Full case details: nej.md/3V6kSuM

Timeline of a clinical course highlighting the treatment and progression of severe Oya virus infection in a patient who also had hepatitis, enteritis, and signs of coagulopathy. It tracks hospital admissions, symptoms, treatments, and recovery progress. Key details include initial symptoms like fever and chills, transfer to Guangzhou Eighth People's Hospital, various treatments such as ibuprofen, antibiotics, antivirals, and plasma transfusion, and the resolution of symptoms. The chart ends with the patient's discharge and follow-up.

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Reposted by NEJM.org

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 24/09/2026

“The discovery of orexins & their link to narcolepsy became central for understanding sleep–wake regulation itself.” 🧪Sebastiaan Overeem & Birgitte R. Kornum report in @nejm.org on the pivotal roles that #LaskerAward winners Mignot & Yanagisawa had in the discovery of orexin: buff.ly/T3CPftu

Overview of the Orexin Peptide System and Its Role in Narcolepsy.
Panel A shows the orexin system, which consists of two neuropeptides produced in the lateral hypothalamus and two G-protein–coupled receptors expressed in most areas of the brain. Projections in a midsagittal schematic of the rodent brain are depicted. Panel B shows deficiency of orexin signaling leading to narcolepsy symptoms in both dogs and rodents. Panel C shows that human patients with narcolepsy lack orexin peptides in the cerebrospinal fluid (CSF), which has led to a reliable diagnostic test. The deficiency is caused by an autoimmune pathogenetic mechanism that has not yet been fully elucidated. As shown in Panel D, the first dual orexin receptor antagonist was approved by the Food and Drug Administration (FDA) in 2014 for the treatment of insomnia.

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NEJM.org @nejm.org · 28/09/2026

In the First Light and Radiant Light trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common. Full results and Research Summary: nej.md/4gvhEZZ

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NEJM.org @nejm.org · 28/09/2026

In a new NEJM Voices blog post, @paulsaxmd.bsky.social explains why the era of the antibiotic dalbavancin, which for years had only been used for emergencies, is upon us. Learn more and sign up for email alerts: nej.md/3Ve4xEp

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NEJM.org @nejm.org · 28/09/2026

The bone scintigraphy of a 46-year-old woman who presented to her primary care physician with a 3-week history of right forefoot pain revealed diffuse skeletal uptake with reduced renal activity and focal uptake at recent fracture sites. Learn more: nej.md/4zOIkwu

$Bone scintigraphy with technetium-99m–labeled hydroxymethylene diphosphonate showed diffuse skeletal radiotracer uptake with reduced renal activity — a distribution pattern consistent with osteomalacia. Black arrows point to focal areas of increased uptake in both femurs that correspond to recent fractures. Yellow arrows point to thoracic scoliosis that is also evident. The anterior view is shown on the left, and the posterior view on the right.$

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NEJM.org @nejm.org · 27/09/2026

In patients with #AFib and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results and Research Summary: nej.md/4ii61XB #ESCCongress

This image contains an excerpt from the Research Summary "Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk" published in the New England Journal of Medicine. It includes a visual representation of a patient with atrial fibrillation and an intermediate risk of stroke. Patient demographics are detailed as 1803 adults, average age of 60 years. The bottom half contains illustrations of the two treatment options: direct oral anticoagulant (DOAC) therapy or no anticoagulation. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 27/09/2026

In an international cohort of 865 patients, Shwachman–Diamond syndrome was associated with a high risk of myeloid cancer and poor survival. Early hematopoietic stem-cell transplantation for high-risk features had a potential benefit. Full study results: nej.md/4AtaUUg

A graph showing the cumulative incidence of hematologic complications in patients with Shwachman–Diamond syndrome, including myelodysplastic syndromes, acute myeloid leukemia, severe bone marrow failure, and hematopoietic stem-cell transplantation indications.

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NEJM.org @nejm.org · 26/09/2026

A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. Read the full case details: nej.md/3TcxPCJ

Three medical images from the Images in Clinical Medicine article "Cerebral Schistosomiasis." Panels A and B: Axial and coronal T1-weighted images obtained after administration of contrast material show an area of linear enhancement (arrow) associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. Panel C: A sample from a circumoval precipitin test for Schistosoma japonicum — which involves incubation of live S. japonicum eggs with patient serum — that was performed. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 26/09/2026

In a new NEJM Voices blog post, @iwashyna.bsky.social reflects on the challenges of stepping outside of the clinician role to support a friend on her post-op journey. Read the full post and sign up for email alerts: nej.md/4yXMgK7

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NEJM.org @nejm.org · 26/09/2026

Table 1 from a new Review Article shows an outline of the associations between common variants and common diseases, according to three categories of ancestry by continental group (African, East Asian, and European). Learn more: nej.md/4Amwv0F

A table showing the associations between common variants and common diseases. It lists genetic variants, their prevalence, estimated relative risk, and associated diseases for European ancestry, East Asian ancestry, and African ancestry.

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NEJM.org @nejm.org · 25/09/2026

A 6-year-old boy is brought to clinic with a 2-year history of a nontender, mobile midline mass of the anterior neck which moves up with tongue protrusion and swallowing. Physical exam is shown. What is the most likely diagnosis? Submit your answer: nej.md/IC09242026

Two medical images from this week's Image Challenge. On the left is a photo of the patient. On the right is an MRI scan of the patient's head and neck. The text “Image Challenge—What is the diagnosis?” sits above the images.

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NEJM.org @nejm.org · 25/09/2026

Case Record of the MGH: A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made. Full case details: nej.md/4h7h0SP

Two anteroposterior radiographs of the patient's legs from "Case Records of the Massachusetts General Hospital: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls."

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NEJM.org @nejm.org · 25/09/2026

A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. What is the most likely diagnosis? Read the case details and vote: nej.md/4rCsVLZ

CT scan of a neck showing diffusely enlarged cervical lymph nodes on the left side with perinodal fat stranding, as well as a lymph node at the level of the lower jugular with internal heterogeneity. Text reads, "Case Challenge" and "Cast your vote before October 8."

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Reposted by NEJM.org

Michelle Kittleson @mkittlesonmd.bsky.social · 22/09/2026

Sometimes the most caring answer is no. A Worthwhile Trade voices.nejm.org/doi/full/10.... @nejm.org

voices.nejm.org

A Worthwhile Trade

Sometimes the most caring answer is no.

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NEJM.org @nejm.org · 24/09/2026

A baby girl was noted to have swelling and cyanosis of the left arm, shoulder, and chest after birth. An MRI showed two fibrous bands penetrating the deep fascia. Read the full case details: nej.md/4drTsWs

Two medical images from the Images in Clinical Medicine article "Congenital Amniotic Band Sequence." Panel A: A photo showing two areas of constriction at the level of the wrist and proximal forearm. Panel B: Magnetic resonance imaging of the arm showed two fibrous bands penetrating the deep fascia. Panel C: A photo of the left arm at the 5-month follow-up.

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NEJM.org @nejm.org · 24/09/2026

New in NEJM: Anticoagulation for Atrial Fibrillation Oveporexton for Narcolepsy Type 1 Anito-cel for Refractory or Recurrent Myeloma Etuvetidigene Autotemcel for Wiskott–Aldrich Syndrome Explore the full issue: nej.md/current-issue

Cover page of NEJM.org dated September 24, 2026. It includes sections like Specialties, Topics, Multimedia, Current Issue, and Learning/CME. Featured content includes "Narcolepsy Research Recognized through the Lasker Award" and an audio interview with Christopher Forrest on Developmental Ecosystems and Health. The page also highlights the Images in Clinical Medicine article
"Cerebral Schistosomiasis," the Quick Take "Anticoagulation in Atrial Fibrillation with Intermediate Stroke Risk," and the editorial "Science behind the Study: CAR with Synthetic Antigen-Binding Domain for Myeloma."

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NEJM.org @nejm.org · 24/09/2026

Sometimes the most caring answer is no. @mkittlesonmd.bsky.social explains why in a new NEJM Voices blog post. Read the post and sign up for email alerts: nej.md/47bwkI6

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NEJM.org @nejm.org · 24/09/2026

The 21st volume of the 𝘐𝘈𝘙𝘊 𝘏𝘢𝘯𝘥𝘣𝘰𝘰𝘬𝘴 summarizes and evaluates evidence for the benefits and harms of lung cancer screening with low-dose CT or chest radiography and assesses tools and strategies to improve screening. Read more about the update: nej.md/4AKtibJ

A table showing the evaluation of the effectiveness of lung cancer screening methods. The first column lists screening method, including low‑dose computed tomography and chest radiography with or without cytologic examination of sputum. For each method, there is body of evidence reviewed and classification for reduction in lung cancer mortality and incidence of stage III or IV lung cancer.

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NEJM.org @nejm.org · 23/09/2026

David J. Hunter, MB, BS, FMedSci, and Michael Inouye, PhD, review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis. Full review: nej.md/4Amwv0F

An illustrated diagram from the Review Article "Clinical Uses of Common Genetic Variants Associated with Common Diseases" that shows the levels of human genome analysis and implications for analysis of disease risk and diagnosis.

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NEJM.org @nejm.org · 23/09/2026

Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA. Full results of TIGET-WAS and phase 3 OTL-103-4 studies: nej.md/4Az7wYj

A chart showing the rate of severe infections according to study phase.

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NEJM.org @nejm.org · 23/09/2026

Yi Lin, MD, PhD, describes the science behind a phase 1 study of anitocabtagene autoleucel, a CAR T cell that deploys a CAR with a novel synthetic antigen-binding domain, in patients with multiple myeloma. Learn more: nej.md/4hF5Gxj

A detailed scientific diagram from "Science behind the Study: Anito-cel for Multiple Myeloma" that shows chimeric antigen receptor (CAR) design.

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NEJM.org @nejm.org · 23/09/2026

In a phase 1 study of anito-cel, a CAR T-cell therapy, for relapsed or refractory myeloma, all 38 patients had a response. Severe cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome were rare. Full study results: nej.md/4ArvK6r

$A graph from an Original Article published in the New England Journal of Medicine article titled "Phase 1 Study of Anito-cel, a D-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma." The graph shows progression-free survival among all patients who received anito-cel. The NEJM identity sits at the bottom.$

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NEJM.org @nejm.org · 23/09/2026

Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet. Full PrEggNut trial results and Research Summary: nej.md/4yE7qNg

This image contains an excerpt from the Research Summary "Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy" published in the New England Journal of Medicine. It shows an illustration of an infant with highlighted areas indicating allergies and graphics of eggs and peanuts. The study involved 2137 pregnant participants with a mean age of 33. Below are two treatment groups, each with illustrations: "High Egg and Peanut Diet" and "Standard Egg and Peanut Diet." A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 23/09/2026

Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease. Read the full correspondence: nej.md/4dCzsAm

A graph showing the clinical course of a previously healthy 12-year-old boy who presented with petechiae and a small hematoma on one arm approximately 1 week after onset of a respiratory adenovirus infection.

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NEJM.org @nejm.org · 23/09/2026

After high-risk adenomas are removed at colonoscopy, guidelines recommend surveillance colonoscopies starting at 3 years, but this screening interval is based on limited evidence. Research findings from the EPoS II trial are summarized in a new Quick Take video. nej.md/46XXNwO

A visual representation of the EPoS II trial, which compared different colonoscopy surveillance intervals for patients with high-risk adenomas removed at colonoscopy.

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NEJM.org @nejm.org · 23/09/2026

In a new NEJM Voices blog post, Don Dizon, MD, argues that artificial intelligence tools used in medicine will never replace clinicians. See why: nej.md/46BpP1a

This image is an illustration of two individuals sitting in a medical office. One is wearing a white coat with a stethoscope around his neck, and holding a tablet, representing a doctor, while the other is engaged in conversation. In the background, a computer monitor displays a document. The text reads: "NEJM Voices | Don Dizon, M.D. The Limits of AI in the Art of Medicine."

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NEJM.org @nejm.org · 22/09/2026

In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone. Full NHS-Galleri trial results: nej.md/4xRZN5L

A bar chart from an Original Article published in the New England Journal of Medicine article titled "Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis." The chart shows the distribution of the route to cancer diagnosis according to trial group after three annual screening rounds. The trial name, NHS-Galleri, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 22/09/2026

Among children with high-risk B-cell acute lymphoblastic leukemia, two cycles of blinatumomab led to a higher 4-year event-free survival than two cycles of chemotherapy (83.0% vs. 70.3%), with a lower risk of serious infection. Full phase 3 AIEOP-BFM ALL 2017 trial results: nej.md/4dBfwOk

This image contains an excerpt from the Research Summary "Blinatumomab as Chemotherapy Replacement in Pediatric ALL." It includes a diagram of how Blinatumomab works as a bispecific T-cell engager directed at CD19 on B cells. Statistics are shown: 709 children, age range of <1 to 17 years. Two treatment groups are compared: Blinatumomab (N=358) and intensive chemotherapy (N=351). A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 22/09/2026

In a new NEJM Voices blog post, @paulsaxmd.bsky.social, describes three recent randomized trials for long Covid, two of which show promising results. Read the latest from Dr. Sax and sign up for email alerts: nej.md/4AqEZ6S

nej.md

Three Very Different Ways to Treat Long Covid

Two that are promising, and one that is difficult to talk about

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NEJM.org @nejm.org · 22/09/2026

Our latest video in partnership with @glaucomflecken.bsky.social summarizes the ALLEGORY trial that evaluated the efficacy and safety of obinutuzumab when added to standard therapy in adults with active systemic lupus erythematosus. Read the full study for free: nej.md/DrG49 #rheumatology

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NEJM.org @nejm.org · 22/09/2026

𝑪𝒂𝒍𝒍 𝒇𝒐𝒓 𝑺𝒖𝒃𝒎𝒊𝒔𝒔𝒊𝒐𝒏𝒔: NEJM’s Images in Clinical Medicine section is now accepting submissions for its third annual Climate Change and Health theme to be published April 2027. Learn more and submit an image: nej.md/event-info

Call for submissions poster from the New England Journal of Medicine, titled "Images in Clinical Medicine: Third Annual Climate Change and Health Theme." Features images with various climate change–related medical conditions. Submissions are accepted on a rolling basis through January 8, 2027. More information at NEJM.org.

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NEJM.org @nejm.org · 21/09/2026

A new review focuses on recent developments in the epidemiologic characteristics, risk factors, prevention, and clinical management of esophageal cancer. Read the full review: nej.md/3Tb2NuX

A bullet list of key points from the Review Article "Esophageal Cancer" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

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NEJM.org @nejm.org · 21/09/2026

Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo. Full SODa-BIC trial results and Research Summary: nej.md/4ofXcyq

This image contains an excerpt from the Research Summary "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis" published in the New England Journal of Medicine. It includes a diagram of a patient with highlighted kidneys and lungs, and an insert labeled "Metabolic Acidosis." Statistics are shown: 500 adults, median age 66 years, with a gender distribution of 57% male and 43% female. Two diagrams represent groups: "Sodium Bicarbonate" with 245 adults and "Placebo" with 255 adults. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 21/09/2026

Whether a maternal diet rich in eggs and peanuts during pregnancy and lactation can reduce the risk of infants developing food allergies is unclear. Research findings from the PrEggNut trial are summarized in a new Quick Take video. nej.md/4y7Gc1m

Illustration showing a silhouette of a pregnant person with a fetus visible inside, a bowl of peanuts and eggs, and an infant with red rash marks on the skin from a food allergy.

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NEJM.org @nejm.org · 20/09/2026

In a prospective trial, patients with serrated polyps had a low 5-year risk of colorectal cancer (1.0%). Read the report on the EPoS III trial: nej.md/3UXhqCA Original Article: Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal (EPoS II trial) nej.md/4yCEnJN

A table showing colorectal cancer mortality, incidence of polyps, and 30-day adverse events at 5-year follow-up. Categories include colorectal cancer diagnosis, death from colorectal cancer, death from any cause, serrated polyp, advanced serrated polyp, adenoma, advanced adenoma, and adverse event. Data includes number of patients and cumulative incidence percentage with 95% confidence intervals.

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NEJM.org @nejm.org · 20/09/2026

In this planned interim analysis of a randomized trial, first surveillance colonoscopy at 5 years after the removal of high-risk adenomas was noninferior to first colonoscopy at 3 years for the incidence of colorectal cancer. Full EPoS II trial results and Research Summary: nej.md/4yCEnJN

This image contains an excerpt from the Research Summary "Colonoscopy Intervals and Colorectal Cancer after Adenoma Removal" published in the New England Journal of Medicine. It includes a diagram of the colon with adenoma removal highlighted. Text states there are 10,799 adult patients with a mean age of 62 years, 65% men and 35% women. Two groups are shown: a 5-year group with less frequent surveillance (5,398 individuals) and a 3-year group with more frequent surveillance (5,401 individuals). A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 20/09/2026

A randomized trial examined whether two cycles of blinatumomab could replace two cycles of chemotherapy in children with newly diagnosed high-risk B-cell acute lymphoblastic leukemia. Research findings from the AIEOP-BFM ALL 2017 trial are summarized in a Quick Take video. nej.md/4cNe3UW

A visual representation of blinatumomab, a bispecific T-cell engager targeting CD19, for children with newly diagnosed high-risk B-cell acute lymphoblastic leukemia.

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NEJM.org @nejm.org · 19/09/2026

A 72-year-old man with hypertension, hyperlipidemia, and a stable ascending aortic aneurysm presented with sudden-onset, severe chest pain. CTA of the chest, abdomen, and pelvis showed a celiac-artery dissection. Read the full case details: nej.md/4yf5FX7

One of three images showing computed tomographic angiography of the chest, abdomen, and pelvis. This one shows an axial view.

Two of three images showing computed tomographic angiography of the chest, abdomen, and pelvis. This one shows a coronal view.

Three of three images showing computed tomographic angiography of the chest, abdomen, and pelvis. This one shows a sagittal view.

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NEJM.org @nejm.org · 19/09/2026

𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗣𝗮𝗿𝗮𝗱𝗶𝗴𝗺𝘀 𝗳𝗼𝗿 𝗘𝘀𝗼𝗽𝗵𝗮𝗴𝗲𝗮𝗹 𝗖𝗮𝗻𝗰𝗲𝗿 𝗔𝗰𝗰𝗼𝗿𝗱𝗶𝗻𝗴 𝘁𝗼 𝗛𝗶𝘀𝘁𝗼𝗹𝗼𝗴𝗶𝗰 𝗧𝘆𝗽𝗲. Shown are the recommended treatment approaches for esophageal squamous-cell carcinoma and esophageal adenocarcinoma. Learn more in a new review: nej.md/3Tb2NuX

An illustrated diagram showing the recommended treatment approaches for esophageal squamous-cell carcinoma and esophageal adenocarcinoma. The upper half shows the treatment of localized cancer with options like radiotherapy, chemotherapy, and surgery. T cells and tumor cells are depicted. The lower half details initial treatment for advanced cancer, highlighting chemotherapy combined with anti-PD-1 treatments. It mentions specific treatments like Zolbetuximab for claudin 18.2 positive tumors and Trastuzumab for HER2 positive tumors. The diagram uses a color-coded layout and illustrations to represent different treatments and targets.

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NEJM.org @nejm.org · 19/09/2026

Metabolic acidosis is common in critically ill adults and is tied to adverse outcomes. Sodium bicarbonate is widely used to treat metabolic acidosis, but evidence supporting its use is unclear. Research findings are summarized in a new Quick Take video. nej.md/4yEDoJa

Illustration showing sodium bicarbonate for a patient with metabolic acidosis and a bottle labeled "Vasopressors."

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NEJM.org @nejm.org · 18/09/2026

A baby girl was noted to have severe swelling and discoloration of the left arm immediately after birth by cesarean section at 38 weeks’ gestation. Read the full case details and submit your answer or see how others responded: nej.md/IC09172026

Two medical images from this week's Image Challenge. A photo on the left shows swelling, cyanosis, and limited movement of the left arm, shoulder, and chest. On the right, MRI shows two fibrous bands extending through the deep fascia. The text “Image Challenge—What is the diagnosis?” sits above the images. The NEJM identity sits at the bottom.

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