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A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video). Read the full case details: nej.md/4z9DOrl

Three still images from the Images in Clinical Medicine article "Serotonin Syndrome." The stills are from a video showing sustained, inducible clonus and patellar hyperreflexia noted in both legs of a patient.

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NEJM.org @nejm.org · 20h

The latest season of “Intention to Treat” is a Signal Awards finalist! 𝙏𝙝𝙚 𝙍𝙖𝙘𝙚 𝙀𝙦𝙪𝙖𝙩𝙞𝙤𝙣 explores how assumptions about race are embedded into medicine and continue to harm Black patients. Explore the podcast: nej.md/ITT Learn about the Signal Awards: nej.md/4e9EUuS

This image is an announcement from the Signal Awards that the Intention to Treat podcast from the New England Journal of Medicine is a finalist in the Limited Series & Specials category for Health & Wellness.

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NEJM.org @nejm.org · 23h

The phase 3 INDIGO trial tested whether weekly obexelimab reduces disease flares and glucocorticoid use in active IgG4-related disease. Research findings are summarized in a new Quick Take video. nej.md/4xSTU7y

An illustration depicting obexelimab for the treatment of IgG4-related disease. On the left, a patient with red highlighted areas on the body representing IgG4-related disease. On the right is a visual representation of obexelimab as a bifunctional monoclonal antibody that inhibits B-cell activity through coengagement of CD19 and FcγRIIb, without depleting B cells.

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NEJM.org @nejm.org · 03/10/2026

In a new NEJM Voices blog post, @paulsaxmd.bsky.social looks at a collaborative attempt to provide consensus on seasonal vaccines for respiratory viruses. Learn more and sign up for email alerts: nej.md/4hAKo2O

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NEJM.org @nejm.org · 02/10/2026

A 35-year-old woman presented with a 20-day history of a painless nipple ulcer without other associated symptoms or skin findings. Read the full case details and submit your answer or see how others responded: nej.md/IC10012026

An immunohistochemical analysis of a a nipple-biopsy specimen. The text “Image Challenge—What is the diagnosis?” sits above the image.

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NEJM.org @nejm.org · 02/10/2026

A new Double Take video describes the burden of global tobacco use and examines evidence-based tobacco-cessation strategies, including their implementation and associated challenges in India and Vietnam. What on our YouTube channel: youtu.be/gJ4UHxVKmQ8

Still frame from a video showing graphic and text warnings highlighting the harms of tobacco on the front and back of smoked tobacco products sold in India. Overlaid on the image reads "Double Take Video: Tobacco-Cessation Treatment for Global Impact."

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NEJM.org @nejm.org · 01/10/2026

Duchenne muscular dystrophy, the most common childhood muscular dystrophy, with an estimated prevalence of 1 in 5000 boys 5 to 9 years of age, is a recessive degenerative disorder caused by variants in the dystrophin gene that lead to deficiency of dystrophin. Learn more: nej.md/4h7h0SP

An illustrated diagram of multisystem findings in patients with Duchenne Muscular Dystrophy. The image highlights physical features such as shoulder and arm positioning, a protruding belly, calf muscles with pseudohypertrophy, and a waddling gait. Annotations describe muscle weakness, respiratory challenges, positional deformity, and difficulty maintaining balance, leading to frequent falls.

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NEJM.org @nejm.org · 01/10/2026

The STAREE trial tested whether atorvastatin prevents first major cardiovascular events and extends disability-free survival in adults 70 years and older without cardiovascular disease. Research findings are summarized in a new Quick Take video. nej.md/4xXoFIG #ESCCongress

Clockwise from top left: A box labeled "Atorvastatin" with two pills is depicted; an illustration showing a heart with an exclamation mark; a silhouette of a patient with a disability; and a group of five silhouettes representing older patients.

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NEJM.org @nejm.org · 01/10/2026

New in NEJM: Atorvastatin in Older Adults (STAREE) Obexelimab for the Treatment of IgG4-Related Disease (INDIGO) Giredestrant–Everolimus in Advanced Breast Cancer (evERA Breast Cancer) Oral Islatravir–Lenacapavir for HIV-1 Treatment (ISLEND-1) Explore the issue: nej.md/current-issue

Cover page of NEJM.org dated October 1, 2026. It includes sections like Specialties, Topics, Multimedia, Current Issue, and Learning/CME. Featured content includes the Double Take video "Tobacco-Cessation Treatment for Global Impact" and an audio interview with Benjamin Scher on opioid
litigation and governance systems for spending related funds. The page also highlights the Clinical Decisions feature "Billing for Patient Portal Messaging" and the Images in Clinical
Medicine article "Serotonin Syndrome."

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NEJM.org @nejm.org · 01/10/2026

In a phase 3, double-blind, placebo-controlled trial involving adults with obesity and type 2 diabetes, the investigational glucagon receptor–GLP-1 receptor dual agonist survodutide led to significant weight reduction. Full SYNCHRONIZE-2 trial results: nej.md/4yrHEMu #EASD2026

A bar chart showing the percent change in body weight from baseline to week 76, derived from an analysis-of-covariance model, for the treatment-regimen estimand, which incorporates the effects of any early discontinuation of survodutide or placebo, the use of protocol-prohibited obesity medications, and the effects of a prolonged dose-escalation period.

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NEJM.org @nejm.org · 01/10/2026

In the conclusion to a comic about a mid-air debacle from visual artist Ryan Montoya, MD, the patient must decide who will handle her care. Read “Chapter 1, Issue 2: Exit Row” in NEJM Voices and sign up for email alerts: nej.md/4jqQc1m

Image of a comic panel featuring a person wearing glasses, looking surprised. Text bubbles read, "What do you mean 'put her in a bathtub of ice??'" and "You should know. You are doctor, no?" Additional text explains that a Russian mother suggested using ice to treat acute abdomen, with the flight crew consulting the captain. A call to read the full comic at voices.nejm.org is displayed at the bottom.

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NEJM.org @nejm.org · 30/09/2026

A 6-year-old boy presented with an asymptomatic lump on the neck. Physical examination showed a nontender, midline mass in the anterior neck; ultrasonography showed a well-defined, hypoechoic mass and normal thyroid gland. Read the full case details: nej.md/3TCTEeT

Two images from the Images in Clinical Medicine "Thyroglossal Duct Cyst." Panel A: A photo showing a nontender, mobile, midline mass in the anterior neck that moved up with tongue protrusion and swallowing. Panel B: Sagittal T2-weighted MRI showing a hyperintense, beaded fistulous duct originating from the tongue base, coursing inferiorly through the hyoid bone, and terminating in a cyst anterior to the thyroid cartilage.

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NEJM.org @nejm.org · 30/09/2026

In ER-positive, HER2-negative advanced breast cancer, giredestrant, an ER degrader and full ER antagonist, plus everolimus led to longer progression-free survival than standard endocrine therapy–everolimus; safety was similar. Full phase 3 evERA Breast Cancer trial results: nej.md/47ryfbF

A graph from an Original Article published in the New England Journal of Medicine article titled "Giredestrant plus Everolimus in Advanced Breast Cancer." The graph shows progression-free survival among patients with ESR1-mutated tumors. The trial name, evERA Breast Cancer, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 30/09/2026

Figure 5 from a Clinical Problem-Solving feature shows the physiologic function of tissue-nonspecific isoenzyme of alkaline phosphatase. Read more about it in “Break a Leg” by M. Wijnen et al.: nej.md/4zOIkwu

An illustrated diagram from the Clinical Problem-Solving "Break a Leg." The top section is labeled "Physiologic Function of Tissue-Nonspecific Isoenzyme of Alkaline Phosphatase (TNSALP)." The bottom section is labeled "Effects of TNSALP Deficiency in Hypophosphatasia."

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NEJM.org @nejm.org · 30/09/2026

Scientists discover new tick-borne virus after testing thousands of patients with mysterious illnesses (FOX News) nej.md/4ykESIP Correspondence: A Zoonotic Orthonairovirus from Febrile Patients in China nej.md/4zPPws9

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NEJM.org @nejm.org · 30/09/2026

Current therapies for narcolepsy type 1 do not target orexin deficiency or treat all symptoms. Oveporexton, an oral orexin receptor 2−selective agonist, has shown efficacy in a phase 2 trial. Research findings from two phase 3 trials are summarized in a new Quick Take video. nej.md/4AsoBTE

Illustration of oveporexton for narcolepsy type 1. A brain is shown with an arrow pointing from a highlighted area to a person sleeping on a desk beside a laptop.

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NEJM.org @nejm.org · 29/09/2026

In the phase 3 TRIUMPH-1 trial involving patients with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events. Full trial results: nej.md/4ycgSHz

A graph from an Original Article published in the New England Journal of Medicine article titled "Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity." The graph shows effect of retatrutide on body weight. The trial name, TRIUMPH-1, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 29/09/2026

The authors of a new article review the ways in which polygenic risk scores, along with the related field of pharmacogenomics, may be useful in clinical practice for the prevention and treatment of common diseases. Read the full article: nej.md/4Amwv0F

A bullet list of key points from the Review Article "Clinical Uses of Common Genetic Variants Associated with Common Diseases" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

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NEJM.org @nejm.org · 29/09/2026

Oya virus, an orthobunyavirus, was identified in a 54-year-old woman who had sepsis-like symptoms, including leukocytosis, thrombocytopenia, elevated liver-function values, and disseminated intravascular coagulation. Full case details: nej.md/3V6kSuM

Timeline of a clinical course highlighting the treatment and progression of severe Oya virus infection in a patient who also had hepatitis, enteritis, and signs of coagulopathy. It tracks hospital admissions, symptoms, treatments, and recovery progress. Key details include initial symptoms like fever and chills, transfer to Guangzhou Eighth People's Hospital, various treatments such as ibuprofen, antibiotics, antivirals, and plasma transfusion, and the resolution of symptoms. The chart ends with the patient's discharge and follow-up.

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NEJM.org @nejm.org · 28/09/2026

In the First Light and Radiant Light trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common. Full results and Research Summary: nej.md/4gvhEZZ

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NEJM.org @nejm.org · 28/09/2026

In a new NEJM Voices blog post, @paulsaxmd.bsky.social explains why the era of the antibiotic dalbavancin, which for years had only been used for emergencies, is upon us. Learn more and sign up for email alerts: nej.md/3Ve4xEp

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NEJM.org @nejm.org · 28/09/2026

The bone scintigraphy of a 46-year-old woman who presented to her primary care physician with a 3-week history of right forefoot pain revealed diffuse skeletal uptake with reduced renal activity and focal uptake at recent fracture sites. Learn more: nej.md/4zOIkwu

$Bone scintigraphy with technetium-99m–labeled hydroxymethylene diphosphonate showed diffuse skeletal radiotracer uptake with reduced renal activity — a distribution pattern consistent with osteomalacia. Black arrows point to focal areas of increased uptake in both femurs that correspond to recent fractures. Yellow arrows point to thoracic scoliosis that is also evident. The anterior view is shown on the left, and the posterior view on the right.$

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NEJM.org @nejm.org · 27/09/2026

In patients with #AFib and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results and Research Summary: nej.md/4ii61XB #ESCCongress

This image contains an excerpt from the Research Summary "Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk" published in the New England Journal of Medicine. It includes a visual representation of a patient with atrial fibrillation and an intermediate risk of stroke. Patient demographics are detailed as 1803 adults, average age of 60 years. The bottom half contains illustrations of the two treatment options: direct oral anticoagulant (DOAC) therapy or no anticoagulation. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 27/09/2026

In an international cohort of 865 patients, Shwachman–Diamond syndrome was associated with a high risk of myeloid cancer and poor survival. Early hematopoietic stem-cell transplantation for high-risk features had a potential benefit. Full study results: nej.md/4AtaUUg

A graph showing the cumulative incidence of hematologic complications in patients with Shwachman–Diamond syndrome, including myelodysplastic syndromes, acute myeloid leukemia, severe bone marrow failure, and hematopoietic stem-cell transplantation indications.

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NEJM.org @nejm.org · 26/09/2026

A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. Read the full case details: nej.md/3TcxPCJ

Three medical images from the Images in Clinical Medicine article "Cerebral Schistosomiasis." Panels A and B: Axial and coronal T1-weighted images obtained after administration of contrast material show an area of linear enhancement (arrow) associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. Panel C: A sample from a circumoval precipitin test for Schistosoma japonicum — which involves incubation of live S. japonicum eggs with patient serum — that was performed. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 26/09/2026

In a new NEJM Voices blog post, @iwashyna.bsky.social reflects on the challenges of stepping outside of the clinician role to support a friend on her post-op journey. Read the full post and sign up for email alerts: nej.md/4yXMgK7

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NEJM.org @nejm.org · 26/09/2026

Table 1 from a new Review Article shows an outline of the associations between common variants and common diseases, according to three categories of ancestry by continental group (African, East Asian, and European). Learn more: nej.md/4Amwv0F

A table showing the associations between common variants and common diseases. It lists genetic variants, their prevalence, estimated relative risk, and associated diseases for European ancestry, East Asian ancestry, and African ancestry.

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NEJM.org @nejm.org · 25/09/2026

A 6-year-old boy is brought to clinic with a 2-year history of a nontender, mobile midline mass of the anterior neck which moves up with tongue protrusion and swallowing. Physical exam is shown. What is the most likely diagnosis? Submit your answer: nej.md/IC09242026

Two medical images from this week's Image Challenge. On the left is a photo of the patient. On the right is an MRI scan of the patient's head and neck. The text “Image Challenge—What is the diagnosis?” sits above the images.

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NEJM.org @nejm.org · 25/09/2026

Case Record of the MGH: A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made. Full case details: nej.md/4h7h0SP

Two anteroposterior radiographs of the patient's legs from "Case Records of the Massachusetts General Hospital: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls."

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NEJM.org @nejm.org · 25/09/2026

A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. What is the most likely diagnosis? Read the case details and vote: nej.md/4rCsVLZ

CT scan of a neck showing diffusely enlarged cervical lymph nodes on the left side with perinodal fat stranding, as well as a lymph node at the level of the lower jugular with internal heterogeneity. Text reads, "Case Challenge" and "Cast your vote before October 8."

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NEJM.org @nejm.org · 24/09/2026

A baby girl was noted to have swelling and cyanosis of the left arm, shoulder, and chest after birth. An MRI showed two fibrous bands penetrating the deep fascia. Read the full case details: nej.md/4drTsWs

Two medical images from the Images in Clinical Medicine article "Congenital Amniotic Band Sequence." Panel A: A photo showing two areas of constriction at the level of the wrist and proximal forearm. Panel B: Magnetic resonance imaging of the arm showed two fibrous bands penetrating the deep fascia. Panel C: A photo of the left arm at the 5-month follow-up.

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NEJM.org @nejm.org · 24/09/2026

New in NEJM: Anticoagulation for Atrial Fibrillation Oveporexton for Narcolepsy Type 1 Anito-cel for Refractory or Recurrent Myeloma Etuvetidigene Autotemcel for Wiskott–Aldrich Syndrome Explore the full issue: nej.md/current-issue

Cover page of NEJM.org dated September 24, 2026. It includes sections like Specialties, Topics, Multimedia, Current Issue, and Learning/CME. Featured content includes "Narcolepsy Research Recognized through the Lasker Award" and an audio interview with Christopher Forrest on Developmental Ecosystems and Health. The page also highlights the Images in Clinical Medicine article
"Cerebral Schistosomiasis," the Quick Take "Anticoagulation in Atrial Fibrillation with Intermediate Stroke Risk," and the editorial "Science behind the Study: CAR with Synthetic Antigen-Binding Domain for Myeloma."

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NEJM.org @nejm.org · 24/09/2026

Sometimes the most caring answer is no. @mkittlesonmd.bsky.social explains why in a new NEJM Voices blog post. Read the post and sign up for email alerts: nej.md/47bwkI6

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NEJM.org @nejm.org · 24/09/2026

The 21st volume of the 𝘐𝘈𝘙𝘊 𝘏𝘢𝘯𝘥𝘣𝘰𝘰𝘬𝘴 summarizes and evaluates evidence for the benefits and harms of lung cancer screening with low-dose CT or chest radiography and assesses tools and strategies to improve screening. Read more about the update: nej.md/4AKtibJ

A table showing the evaluation of the effectiveness of lung cancer screening methods. The first column lists screening method, including low‑dose computed tomography and chest radiography with or without cytologic examination of sputum. For each method, there is body of evidence reviewed and classification for reduction in lung cancer mortality and incidence of stage III or IV lung cancer.

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NEJM.org @nejm.org · 23/09/2026

David J. Hunter, MB, BS, FMedSci, and Michael Inouye, PhD, review the ways common genetic variants, polygenic risk scores, and pharmacogenomic genotyping may be useful in the prevention of common diseases and the treatment of common diseases after diagnosis. Full review: nej.md/4Amwv0F

An illustrated diagram from the Review Article "Clinical Uses of Common Genetic Variants Associated with Common Diseases" that shows the levels of human genome analysis and implications for analysis of disease risk and diagnosis.

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NEJM.org @nejm.org · 23/09/2026

Persons with Wiskott–Aldrich syndrome were treated with an autologous gene therapy consisting of hematopoietic stem and progenitor cells transduced ex vivo with a lentiviral vector encoding WAS complementary DNA. Full results of TIGET-WAS and phase 3 OTL-103-4 studies: nej.md/4Az7wYj

A chart showing the rate of severe infections according to study phase.

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NEJM.org @nejm.org · 23/09/2026

Yi Lin, MD, PhD, describes the science behind a phase 1 study of anitocabtagene autoleucel, a CAR T cell that deploys a CAR with a novel synthetic antigen-binding domain, in patients with multiple myeloma. Learn more: nej.md/4hF5Gxj

A detailed scientific diagram from "Science behind the Study: Anito-cel for Multiple Myeloma" that shows chimeric antigen receptor (CAR) design.

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NEJM.org @nejm.org · 23/09/2026

In a phase 1 study of anito-cel, a CAR T-cell therapy, for relapsed or refractory myeloma, all 38 patients had a response. Severe cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome were rare. Full study results: nej.md/4ArvK6r

$A graph from an Original Article published in the New England Journal of Medicine article titled "Phase 1 Study of Anito-cel, a D-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma." The graph shows progression-free survival among all patients who received anito-cel. The NEJM identity sits at the bottom.$

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NEJM.org @nejm.org · 23/09/2026

Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet. Full PrEggNut trial results and Research Summary: nej.md/4yE7qNg

This image contains an excerpt from the Research Summary "Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy" published in the New England Journal of Medicine. It shows an illustration of an infant with highlighted areas indicating allergies and graphics of eggs and peanuts. The study involved 2137 pregnant participants with a mean age of 33. Below are two treatment groups, each with illustrations: "High Egg and Peanut Diet" and "Standard Egg and Peanut Diet." A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 23/09/2026

Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease. Read the full correspondence: nej.md/4dCzsAm

A graph showing the clinical course of a previously healthy 12-year-old boy who presented with petechiae and a small hematoma on one arm approximately 1 week after onset of a respiratory adenovirus infection.

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NEJM.org @nejm.org · 23/09/2026

After high-risk adenomas are removed at colonoscopy, guidelines recommend surveillance colonoscopies starting at 3 years, but this screening interval is based on limited evidence. Research findings from the EPoS II trial are summarized in a new Quick Take video. nej.md/46XXNwO

A visual representation of the EPoS II trial, which compared different colonoscopy surveillance intervals for patients with high-risk adenomas removed at colonoscopy.

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NEJM.org @nejm.org · 23/09/2026

In a new NEJM Voices blog post, Don Dizon, MD, argues that artificial intelligence tools used in medicine will never replace clinicians. See why: nej.md/46BpP1a

This image is an illustration of two individuals sitting in a medical office. One is wearing a white coat with a stethoscope around his neck, and holding a tablet, representing a doctor, while the other is engaged in conversation. In the background, a computer monitor displays a document. The text reads: "NEJM Voices | Don Dizon, M.D. The Limits of AI in the Art of Medicine."

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NEJM.org @nejm.org · 22/09/2026

In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone. Full NHS-Galleri trial results: nej.md/4xRZN5L

A bar chart from an Original Article published in the New England Journal of Medicine article titled "Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis." The chart shows the distribution of the route to cancer diagnosis according to trial group after three annual screening rounds. The trial name, NHS-Galleri, is in parentheses after the title. The NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 22/09/2026

Among children with high-risk B-cell acute lymphoblastic leukemia, two cycles of blinatumomab led to a higher 4-year event-free survival than two cycles of chemotherapy (83.0% vs. 70.3%), with a lower risk of serious infection. Full phase 3 AIEOP-BFM ALL 2017 trial results: nej.md/4dBfwOk

This image contains an excerpt from the Research Summary "Blinatumomab as Chemotherapy Replacement in Pediatric ALL." It includes a diagram of how Blinatumomab works as a bispecific T-cell engager directed at CD19 on B cells. Statistics are shown: 709 children, age range of <1 to 17 years. Two treatment groups are compared: Blinatumomab (N=358) and intensive chemotherapy (N=351). A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 22/09/2026

Our latest video in partnership with @glaucomflecken.bsky.social summarizes the ALLEGORY trial that evaluated the efficacy and safety of obinutuzumab when added to standard therapy in adults with active systemic lupus erythematosus. Read the full study for free: nej.md/DrG49 #rheumatology

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NEJM.org @nejm.org · 22/09/2026

𝑪𝒂𝒍𝒍 𝒇𝒐𝒓 𝑺𝒖𝒃𝒎𝒊𝒔𝒔𝒊𝒐𝒏𝒔: NEJM’s Images in Clinical Medicine section is now accepting submissions for its third annual Climate Change and Health theme to be published April 2027. Learn more and submit an image: nej.md/event-info

Call for submissions poster from the New England Journal of Medicine, titled "Images in Clinical Medicine: Third Annual Climate Change and Health Theme." Features images with various climate change–related medical conditions. Submissions are accepted on a rolling basis through January 8, 2027. More information at NEJM.org.

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NEJM.org @nejm.org · 21/09/2026

A new review focuses on recent developments in the epidemiologic characteristics, risk factors, prevention, and clinical management of esophageal cancer. Read the full review: nej.md/3Tb2NuX

A bullet list of key points from the Review Article "Esophageal Cancer" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

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NEJM.org @nejm.org · 21/09/2026

Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo. Full SODa-BIC trial results and Research Summary: nej.md/4ofXcyq

This image contains an excerpt from the Research Summary "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis" published in the New England Journal of Medicine. It includes a diagram of a patient with highlighted kidneys and lungs, and an insert labeled "Metabolic Acidosis." Statistics are shown: 500 adults, median age 66 years, with a gender distribution of 57% male and 43% female. Two diagrams represent groups: "Sodium Bicarbonate" with 245 adults and "Placebo" with 255 adults. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

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NEJM.org @nejm.org · 21/09/2026

Whether a maternal diet rich in eggs and peanuts during pregnancy and lactation can reduce the risk of infants developing food allergies is unclear. Research findings from the PrEggNut trial are summarized in a new Quick Take video. nej.md/4y7Gc1m

Illustration showing a silhouette of a pregnant person with a fetus visible inside, a bowl of peanuts and eggs, and an infant with red rash marks on the skin from a food allergy.

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NEJM.org @nejm.org · 20/09/2026

In a prospective trial, patients with serrated polyps had a low 5-year risk of colorectal cancer (1.0%). Read the report on the EPoS III trial: nej.md/3UXhqCA Original Article: Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal (EPoS II trial) nej.md/4yCEnJN

A table showing colorectal cancer mortality, incidence of polyps, and 30-day adverse events at 5-year follow-up. Categories include colorectal cancer diagnosis, death from colorectal cancer, death from any cause, serrated polyp, advanced serrated polyp, adenoma, advanced adenoma, and adverse event. Data includes number of patients and cumulative incidence percentage with 95% confidence intervals.

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