iiinova — where your digital self keeps evolving

Nejc Haberman

@nejchaberman.bsky.social

169 followers 148 following 28 posts

Posts Replies Media

Nejc Haberman @nejchaberman.bsky.social · 05/03/2026

Exciting day ahead at the 2nd Genome Regulation through RNA Conference! 🧬 I’ll be giving a talk today on our latest work on 3'UTR-derived capped RNAs (ucRNAs). Looking forward to the feedback and discussions with this incredible community! 🇲🇽✨ #RNA #conference @fusionconf.bsky.social

050

Nejc Haberman @nejchaberman.bsky.social · 04/03/2026

Thrilled to be in Playa Mujeres, Mexico 🇲🇽 for the 2nd Genome Regulation through RNA Conference! I’ll be chairing this afternoon’s session. Looking forward to hearing all the exciting talks and engaging in deep discussions at this amazing venue. 🧬 #RNA #Genomics #PlayaMujeres @fusionconf.bsky.social

050

Nejc Haberman @nejchaberman.bsky.social · 29/08/2025

What an incredible end to the Eukaryotic RNA Turnover meeting in Brighton! Fantastic talks, inspiring speakers, and amazing to meet so many new RNA enthusiasts. Thanks @biochemsoc.bsky.social for a great conference! #BiochemEvent

082

Nejc Haberman @nejchaberman.bsky.social · 28/08/2025

Fantastic day at the Eukaryotic RNA Turnover meeting! We wrapped up insightful sessions on: - RNA therapeutics & RNA modification - RNA molecular machines & RNA-binding proteins - RNA localization & turnover Thanks to all speakers! @biochemsoc.bsky.social #BiochemEvent

061

Nejc Haberman @nejchaberman.bsky.social · 28/08/2025

What a beautiful morning by the Brighton sea to kick off another exciting session at the Eukaryotic RNA Turnover meeting! ☀️🌊 @biochemsoc.bsky.social #BiochemEvent

051

Nejc Haberman @nejchaberman.bsky.social · 03/06/2025

Huge thanks to everyone who made the RNA conference in San Diego such a great experience! Grateful for all the insightful conversations—especially the thoughtful suggestions during the poster session. Feeling inspired! #RNA2025 #RNA25

091

Nejc Haberman @nejchaberman.bsky.social · 22/11/2024

By scholargoggler.com

010

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

9/10 In summary, we demonstrate that that capped 3′UTR-derived RNAs arise from structured G-motif-rich regions bound by AGO2 and UPF1, and they localise separately from their parental mRNAs.

100

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

8/10 Using high-resolution imaging, we validated that 3′UTR-derived RNAs localise differently from their parental mRNAs within the cell, hinting at potential independent functions.

100

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

7/10 We also found that cytoplasmic capping can occur subsequent to AGO2/siRNA-mediated cleavage, by analysing FANTOM5 CAGE from siRNA-treated samples. Our findings demonstrate that capping can readily follow cytoplasmic cleavage, and is not exclusive to transcriptional initiation.

111

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

6/10 Our analysis shows that AGO2 binds upstream of 3′UTR-derived RNA start sites—independent of miRNA binding. Interestingly, G4 motifs influence the binding positions of both AGO2 and UPF1, shaping the capping sites.

100

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

5/10 By integrating AGO2-eiCLIP, eCLIP, and CAGE-seq, we found their origins linked to RNA-binding proteins, specifically AGO2 and UPF1. These sites are often rich in G-motifs capable of forming G-Quadruplexes.

111

Nejc Haberman @nejchaberman.bsky.social · 15/11/2024

2/10 CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood.

100