iiinova — where your digital self keeps evolving

Reposted by Nicolas Caramello

ESRF @esrf.fr · 04/06/2026

Inspired by Nature. Designed for coeliac disease. A team of scientists scientists have designed a newly-designed enzyme, dubbed celiacase, that could potentially alleviate celiac disease. www.esrf.fr/home/news/ge...

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Reposted by Nicolas Caramello

La Science, CQFD @sciencecqfd.bsky.social · 03/06/2026

L'optogénétique, kézako ? Suivez-ici le fil de notre entretien avec Valentina Emiliani ! #ScienceCQFD

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Reposted by Nicolas Caramello

ESRF @esrf.fr · 18/05/2026

By pressurising enzyme crystals with gas and collecting X-ray data, researchers have mapped the routes CO₂ takes as it travels through the protein, revealing a 'waiting room' where substrate molecules queue up just outside the catalytic centre before being processed. www.esrf.fr/home/news/sp...

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Reposted by Nicolas Caramello

Structural Biology @actacrystd.iucr.org · 28/04/2026

The structural response of two metal-containing proteins to X-ray-induced reduction of metals in the active site differs markedly at room and cryogenic temperature #InCrystalloUVVisAbsorptionSpectroscopy #RoomTemperatureXRayCrystallography doi.org/10.1107/S205...

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Reposted by Nicolas Caramello

Structural Biology @actacrystd.iucr.org · 09/03/2026

Take a look at our March issue: journals.iucr.org/d/issues/202... On the cover: the response of two paradigmatic metalloproteins of different types, one iron-containing and one copper-containing, to X-ray-induced metal reduction at cryo- and room temperature journals.iucr.org/d/issues/202...

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Reposted by Nicolas Caramello

Geoffroy Mallaret @gmallaret.bsky.social · 22/11/2025

Thrilled to share our recent research with Laetitia Davidovic, investigating how p-cresol contributes to social deficits by modulating host catecholamine-biosynthesizing enzymes. A huge thank-you to the entire team for their exceptional work. Hope you enjoy it! www.nature.com/articles/s42...

nature.com

The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits - Communications Biology

The microbial metabolite p-cresol and p-cresol sulfate accumulate in brainstem and inhibit TH and DBH, key enzymes in catecholamine synthesis. This disruption alters brain function and behavior, ...

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Reposted by Nicolas Caramello

CNRS Biologie @cnrsbiologie.bsky.social · 15/09/2025

#ResultatScientifique🔎| Saviez-vous que certaines protéines de notre corps règlent l’horloge biologique… et pourraient aussi aider les oiseaux à trouver leur chemin en plein vol ? 🦅 ✍️ @antoineroyant.bsky.social 📕 Science Advances | buff.ly/xSpVhGC

buff.ly

Dans la structure des cryptochromes, le secret des horloges et boussoles biologiques

Les cryptochromes, protéines sensibles à la lumière bleue, règlent notre horloge biologique et pourraient aussi servir de boussole interne aux oiseaux m

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Reposted by Nicolas Caramello

Virgile Adam @drfluo.bsky.social · 17/07/2025

New paper about the slow maturation of the fluorescent protein mEos4b and how to improve it (onlinelibrary.wiley.com/doi/10.1002/...)

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Reposted by Nicolas Caramello

EMBL @embl.org · 07/07/2025

EMBL Hamburg scientists have discovered a group of microbial cold-loving molecules, ‘cryorhodopsins’, with extraordinary abilities. They are the first observed molecules that can act as both on and off switches for electrical activity in cells. www.embl.org/news/science...

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Nicolas Caramello @ncaramel.bsky.social · 03/06/2025

I am very happy to report that our paper for the in crystallo optical spectroscopy toolbox, developed during my PhD, is out! This is a graphical interface into which you can load UV-vis absorption and fluorescence spectra for baseline correction and analysis.

journals.iucr.org

The in crystallo optical spectroscopy toolbox

The rise of time-resolved macromolecular crystallography has been accompanied by renewed interest in companion biophysical characterization methods applicable to molecules both in solution and in crys...

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Reposted by Nicolas Caramello

INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · 19/04/2025

High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Congratulations!✨ www.science.org/doi/10.1126/... #OpenAccess

science.org

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport

Bacteria aptly use fundamental mechanisms for light-driven proton transfer across a membrane.

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Reposted by Nicolas Caramello

Virgile Adam @drfluo.bsky.social · 01/06/2025

New paper about a python software to process spectra within protein crystals (journals.iucr.org/j/issues/202...)

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Reposted by Nicolas Caramello

ESRF @esrf.fr · 20/05/2025

Scientists unveil the mechanism of light-sensing proteins that regulate internal clock. They used the TR-icOS instrument at the ESRF for spectroscopic characterization of the crystals. www.esrf.fr/home/news/ge...

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Reposted by Nicolas Caramello

山元淳平/Junpei Yamamoto @junpeiyamamoto.bsky.social · 16/05/2025

Congrats for publication!🥳🎉Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography | Science Advances www.science.org/doi/10.1126/...

science.org

Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography

Time-resolved crystallography unveils how light-driven chromophore reduction sparks dramatic structural change in a photoreceptor.

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Nicolas Caramello @ncaramel.bsky.social · 19/05/2025

At long last, our first article on the TR-SFX study of light signalling in a cryptochrome (the animal-like cryptochrome from C. rheinardtii) is finally out! It features some of the most beautiful maps I have ever worked with and insight on the role of FAD protonation in committing CraCRY... (1/3)

science.org

Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography

Time-resolved crystallography unveils how light-driven chromophore reduction sparks dramatic structural change in a photoreceptor.

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Reposted by Nicolas Caramello

ESRF @esrf.fr · 08/01/2025

Check out this article to know more about the EBS flagship beamline ID29!

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Reposted by Nicolas Caramello

DdS @ID29 @ddsid29.bsky.social · 07/01/2025

We are thrilled to introduce Serial Microsecond Crystallography at #ID29 at the @esrf.fr #EBS 4th generation synchrotron In collaboration with @embl.org Discover the advantages of the unique capabilities of ID29, from Its microsecond pulses, repetition rate, bandwidth and low sample consumption.

nature.com

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