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Nature Reviews Methods Primers

@natrevmethodsprimers.nature.com
4.2K followers 220 following 196 posts

Nature Reviews Methods Primers publishes Primers - introductory reviews on methods and techniques across the life and physical sciences. www.nature.com/nrmp

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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 01/10/2026
And the related #PrimeView overviews the process from lab-based microstructure analysis to eventual industrial implementation. www.nature.com/articles/s43...
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Selective gas adsorption in microporous materials - Nature Reviews Methods Primers
This PrimeView highlights the different type of data collected from microporous adsorbents throughout the process from laboratory development to industrial application.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 01/10/2026
Micropore design is crucial for improving gas separation technologies. This #Primer discusses how tuning pore size, shape, and chemistry can optimize selectivity and capacity, offering alternatives to energy-intensive industrial gas separations. www.nature.com/articles/s43...
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Selective gas adsorption in microporous materials - Nature Reviews Methods Primers
This Primer highlights micropore design principles governed by distinct separation mechanisms to resolve key performance trade-offs in industrial gas separations. It outlines the experimental workflow...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 24/09/2026
And check out the related #PrimeView featuring some of the most common POMs www.nature.com/articles/s43...
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Polyoxometalates for redox chemistry - Nature Reviews Methods Primers
This PrimeView highlights the key features of the most prominent species of polyoxometalates.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 24/09/2026
#Polyoxometalates (POMs), are gaining attention for their potential in sustainable energy and catalysis technologies. The #Primer highlights the atomic-level structure and reactivity of POMs alongside their application in next-generation energy solutions. www.nature.com/articles/s43...
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Polyoxometalates for redox chemistry - Nature Reviews Methods Primers
Polyoxometalates (POMs) are anionic molecular metal oxide clusters composed of high-valent early transition metals. In this Primer, Anjass et al. describe how redox-active POMs are selected, synt...
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Reposted by Nature Reviews Methods Primers
Nature Portfolio @natureportfolio.nature.com · 23/09/2026
Meet the 13 candidates and initiatives shortlisted for the 2026 Nature Awards for Inspiring Women in Science, in partnership with The Estée Lauder Companies. Congratulations to all! Learn more: go.nature.com/4xY1ZbR #WomenInSTEM
An image showing the headshots of the women on the shortlists for the 2026 Inspiring Women in Science Award.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 18/09/2026
And the associated #PrimeView highlights the experimental setup with an emphasis on photothermal expansion: www.nature.com/articles/s43...
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Optical photothermal infrared spectroscopy - Nature Reviews Methods Primers
This PrimeView highlights the experimental set-up for optical photothermal infrared spectroscopy, which can be used in transmission or reflection configuration and probe both IR- and Raman-active mode...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 18/09/2026
From @andrewpault.bsky.social and co-workers is a new #Primer on optical photothermal infrared spectroscopy - a technique that uses a visible probe laser to improve the spatial resolution down to sub-micrometers. Check it out here: www.nature.com/articles/s43...
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Optical photothermal infrared spectroscopy - Nature Reviews Methods Primers
Optical photothermal infrared spectroscopy is capable of submicrometre infrared analysis with minimal water interference and scattering artefacts. This indirect, non-contact pump–probe method circumve...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 16/09/2026
Looking forward to welcoming the scientific community to London 13–15 Oct 2026 for Reframing Precision Medicine: Innovation to Implementation. We’ll explore how multi omics, AI & big data can move personalised care from promise to practice. Learn more at go.nature.com/471AdQb
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Reframing Precision Medicine: Innovation to Implementation | 13–15 October 2026
A Nature conference reimagining what it means to deliver truly personalised care in the next decade.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
And a helpful perspective from Emily Sprague-Klein and Daniel Mittleman on starting an ultrafast spectroscopy lab: rdcu.be/MftQ7h214nha
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
Guidance from @apcarpenter1.bsky.social and Rebecca Altman on how to choose ultrafast equipment and incorporate AI: rdcu.be/ZYVLJgraFp6a
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
A discussion on how ultrafast laser pulses can be used in additive manufacturing from Paul Somers and Martin Wegener: rdcu.be/1g8PQgEViN4a
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
A Q&A with Giulio Cerullo on the current state of ultrafast methods: rdcu.be/9s3DcneBgMLa
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
This collection also include an editorial on the importance of knowledge transfer in ultrafast methods: rdcu.be/LwLYMvoS4jSa
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
🚨⏩ Check out our newest collection on #ultrafast methods - highlighting Primers articles on techniques that use ultrafast laser pulses for spectroscopy, microscopy, and manufacturing www.nature.com/collections/...
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Ultrafast methods
This Collection features Primers, PrimeViews, Comments, and a Q&A on spectroscopy and microscopy methods.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
This #PrimeView highlights the use of long-read sequencing for examining previously overlooked sources of genetic and regulatory variation. www.nature.com/articles/s43...
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Bioinformatics for human long-read whole genome sequencing - Nature Reviews Methods Primers
This PrimeView highlights the use of long-read sequencing for examining previously overlooked sources of genetic and regulatory variation.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 10/09/2026
Long-read #sequencing is transforming our understanding of the human #genome by revealing complex genetic variations often missed by traditional methods. This #Primer explores the computational techniques enabling these insights. www.nature.com/articles/s43...
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Bioinformatics for human long-read whole-genome sequencing - Nature Reviews Methods Primers
Long-read sequencing facilitates observation of contiguous DNA molecules, providing access to variants previously ignored. In this Primer, Zheng et al. discuss the computational foundations of long-re...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 03/09/2026
And check out this #PrimeView featuring the workflow for generating highly multiplexed tissue images using imaging mass cytometry. www.nature.com/articles/s43...
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Imaging mass cytometry - Nature Reviews Methods Primers
This PrimeView highlights the workflow for generating highly multiplexed tissue images using imaging mass cytometry.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 03/09/2026
Imaging mass cytometry (IMC) offers a powerful approach for tissue imaging, detecting up to 45 markers at subcellular resolution. This #Primer from @bb-lab.bsky.social and team guides users through the IMC workflow, from antibody conjugation to data analysis. www.nature.com/articles/s43...
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Imaging mass cytometry - Nature Reviews Methods Primers
Imaging mass cytometry is a highly multiplexed tissue-imaging technique that allows the simultaneous in situ detection of up to 45 markers with subcellular-level resolution. In this Primer, Meyer et a...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 27/08/2026
And check out the ways in which high-temperature electrochemical cells can be interrogated using X-ray techniques in this #PrimeView www.nature.com/articles/s43...
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In situ/operando X-ray methods for investigating high-temperature electrocatalysis - Nature Reviews Methods Primers
This PrimeView highlights the ways in which high-temperature electrochemical cells can be interrogated using X-ray techniques.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 27/08/2026
High-temp #electrochemical devices are vital for low-carbon energy. This #Primer outlines in situ/#operando methods to study their complex reactions, focusing on X-ray techniques and practical considerations for researchers. www.nature.com/articles/s43...
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In situ/operando X-ray methods for investigating high-temperature electrocatalysis - Nature Reviews Methods Primers
High-temperature electrochemical devices operate at gas–solid interfaces in highly redox-active environments. In situ and operando characterization techniques are crucial for monitoring the structural...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 14/08/2026
Join us at Princeton University this October to hear the latest electron microscopy instrumentation and methods driving progress in the physical and life sciences. go.nature.com/4h0zAME
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4th Frontiers in Electron and Scanning Probe Microscopy for the Physical and Life Sciences
Advances in electron microscopy instrumentation and methods continue to drive progress in the physical and life sciences. The 4th edition of this conference will bring together researchers from physic...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 14/08/2026
Looking forward to welcoming the scientific community to London 13–15 Oct 2026 for Reframing Precision Medicine: Innovation to Implementation. We’ll explore how multi omics, AI & big data can move personalised care from promise to practice. Learn more at go.nature.com/471AdQb
go.nature.com
Reframing Precision Medicine: Innovation to Implementation | 13–15 October 2026
A Nature conference reimagining what it means to deliver truly personalised care in the next decade.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 13/08/2026
And check out the related #PrimeView, highlighting the use of positrons to detect crystalline imperfections, such as vacancies or void spaces. www.nature.com/articles/s43...
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Positron annihilation spectroscopy - Nature Reviews Methods Primers
This PrimeView highlights the use of positrons, typically generated from radioisotopes, to detect crystalline imperfections, such as vacancies or void spaces, in positron annihilation spectroscopy.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 13/08/2026
#Positron annihilation spectroscopy probes atomic-level structures by detecting γ-photons from positron-electron annihilation. In this week's #Primer, learn about the method, and the recent advances in studying defects in materials and interfaces. www.nature.com/articles/s43...
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Positron annihilation spectroscopy - Nature Reviews Methods Primers
This Primer provides an introduction to positron annihilation spectroscopy and its uses in studying atomic-scale structures in solids.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
Hope you enjoy these articles, and the eclipse! Let us know how these #Primers have helped your #astronomy research and if there are additional topics that you would like to see a Primer on!
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
This #PrimeView highlights the application of astronomical radio interferometry for the sensitive study of #celestial objects. rdcu.be/fzx1S
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Astronomical radio interferometry
Nature Reviews Methods Primers - This PrimeView highlights the application of astronomical radio interferometry for the sensitive study of celestial objects.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
Lastly, check out #astronomical radio #interferometry which allows for celestial objects to be studied at submillimeter wavelengths. www.nature.com/articles/s43...
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Astronomical radio interferometry - Nature Reviews Methods Primers
Arrays of element antennas in radio interferometry enable the study of celestial objects with angular resolutions comparable with, or surpassing, optical imaging at wavelengths thousands of times shor...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
This #PrimeView on adaptive optics highlights the general experimental setup of this technique that corrects image imperfections in astronomy, vision science and microscopy. rdcu.be/fzx0R
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Adaptive optics for high-resolution imaging
Nature Reviews Methods Primers - This PrimeView on adaptive optics highlights the general experimental setup of this technique that corrects image imperfections in astronomy, vision science and...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
How are optics used in space? Well, they are adapted of course! #Adaptiveoptics www.nature.com/articles/s43...
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Adaptive optics for high-resolution imaging - Nature Reviews Methods Primers
This Primer provides an overview of the general principles of adaptive optics and explores the different ways in which adaptive optics can correct optical aberrations for high-resolution imaging in th...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
This #PrimeView highlights different applications of #muographic imaging, cryptography, positioning, navigation and timing. rdcu.be/fzxZg
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Muography
Nature Reviews Methods Primers - This PrimeView highlights different applications of muographic imaging, cryptography, positioning, navigation and timing.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
How about #muography which uses the heavier nature of cosmic-ray #muons in various technology www.nature.com/articles/s43...
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Muography - Nature Reviews Methods Primers
Muography takes advantage of the high penetrating power and relativistic nature of cosmic-ray muons for imagery; positioning, navigation, timing; and secured communications. This Primer provides an ov...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 12/08/2026
Catching the #eclipse today? Have a look at these space related #Primers, #PrimeViews, and comments for fun too! 🌔📡 Starting of with the unique usage of #Raman in space: www.nature.com/articles/s43...
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Using Raman spectrometers developed for space exploration in other extreme environments - Nature Reviews Methods Primers
Optimizing Raman spectrometer designs for use in extreme environments can enable acquisition of critical information that may not be accessible in situ by humans. Technology advancements currently bei...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 06/08/2026
This #PrimeView highlights the landscape of noise equivalent pressures for different detectors used in photoacoustic tomography. www.nature.com/articles/s43...
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Noise-equivalent pressures of ultrasound detectors used in photoacoustic tomography - Nature Reviews Methods Primers
This PrimeView highlights the landscape of noise equivalent pressures (NEPs) for different detectors used in photoacoustic tomography.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 06/08/2026
#Photoacoustic #tomography (PAT) relies on optically excited ultrasound waves for imaging. This week's #Primer highlights the importance of noise-equivalent pressures for various detectors, aiding in the selection and development of PAT technologies. www.nature.com/articles/s43...
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Noise-equivalent pressures of ultrasound detectors used in photoacoustic tomography - Nature Reviews Methods Primers
Photoacoustic tomography (PAT) is a biomedical imaging technique based on the use of optically excited ultrasound waves. In this Primer, Guggenheim et al. describe the noise-equivalent pressures repor...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 23/07/2026
And check out the related #PrimeView, highlighting the instrumentation for #NSE www.nature.com/articles/s43...
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Neutron spin echo spectroscopy - Nature Reviews Methods Primers
This PrimeView highlights the instrumentation for neutron spin echo spectroscopy, which measures neutron velocity changes in a magnetic field using spin precession angle measurements.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 23/07/2026
Neutron spin echo (NSE) spectroscopy offers insights into the internal dynamics and diffusion processes of materials. This #Primer explores its applications across various systems, from proteins to quantum magnets and catalysts. www.nature.com/articles/s43...
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Neutron spin echo spectroscopy - Nature Reviews Methods Primers
Neutron spin echo spectroscopy investigates internal dynamics and diffusion in materials, using advanced instruments and data collection techniques. In this Primer, Faraone et al. discuss how neutron ...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 16/07/2026
This #PrimeView highlights the workflow for GPCR peptide discovery from biodiversity-derived sequences, structural data and peptide libraries. www.nature.com/articles/s43...
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Peptide ligand discovery of G protein-coupled receptors - Nature Reviews Methods Primers
This PrimeView highlights the workflow for GPCR peptide discovery from biodiversity-derived sequences, structural data and peptide libraries.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 16/07/2026
Recent advances in #peptide-GPCR interactions are transforming drug discovery. This #Primer details experimental and computational approaches, from in silico peptide mining to modern biosensor assays, paving the way for novel therapeutics. www.nature.com/articles/s43...
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Peptide ligand discovery of G protein-coupled receptors - Nature Reviews Methods Primers
Peptides have become an increasingly important and versatile ligand type for G protein-coupled receptors (GPCRs). In this Primer, Hermes et al. discuss the experimental and computational workflow...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 14/07/2026
The #PrimeView features applications of distributional regression in health, ecology, and environmental science. www.nature.com/articles/s43...
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Distributional regression using generalized additive models for location, scale and shape - Nature Reviews Methods Primers
This PrimeView discusses the range of data to which distributional regression can be applied to understand deviations from the response norm and their real-world impact.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 14/07/2026
Explore how generalized additive models for location, scale, and shape (GAMLSS) extend traditional regression by modeling mean, variance, and more. This #Primer highlights the role of distributional regression in risk assessment and predicting uncertainty. www.nature.com/articles/s43...
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Distributional regression using generalized additive models for location, scale and shape - Nature Reviews Methods Primers
Distributional regression models entire conditional response distributions. In this Primer, Merder et al. discuss how distributional regression is used to predict uncertainty and extreme conditions in...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 02/07/2026
And choose your ideal polymer in the #PrimeView here: www.nature.com/articles/s43...
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Synthesis and applications of conductive polymers - Nature Reviews Methods Primers
This PrimeView highlights common conductive polymers, their electronic properties, and applications in flexible electronics and biocompatible devices.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 02/07/2026
Conductive polymers (CPs) have unique optoelectronic properties and mechanical ductility. This #Primer discusses how these features make CPs suitable for next-gen optoelectronic and bioelectronic devices. www.nature.com/articles/s43...
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Synthesis and applications of conductive polymers - Nature Reviews Methods Primers
Conductive polymers (CPs) are π-conjugated organic semiconductors that exhibit electrical conductivities similar to insulators and metals while maintaining the flexibility of plastics. This Primer pro...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 25/06/2026
This #PrimeView highlights the standardized reporting procedures required when publishing results of laser cooling experiments. www.nature.com/articles/s43...
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Solid-state laser cooling - Nature Reviews Methods Primers
This PrimeView highlights the standardized reporting procedures required when publishing results of laser cooling experiments.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 25/06/2026
Solid-state laser cooling has emerged as a promising alternative to traditional cryogenic methods. Check out this #Primer outlining the experimental considerations for laser cooling, emphasizing materials, cooling metrics, and thermometry. www.nature.com/articles/s43...
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Solid-state laser cooling - Nature Reviews Methods Primers
Solid-state laser cooling is a technique used to lower the temperature of a condensed-phase system through its interaction with light. In this Primer, Ding et al. discuss the fundamental principles of...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 18/06/2026
And this #PrimeView highlights the use of MALDI IMS in the untargeted mapping of various biomolecules to link their distribution to various cellular contexts. www.nature.com/articles/s43...
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Matrix-assisted laser desorption/ionization imaging mass spectrometry - Nature Reviews Methods Primers
This PrimeView highlights the use of MALDI IMS in the untargeted mapping of various biomolecules to link their distribution to various cellular contexts.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 18/06/2026
Matrix-assisted laser desorption/ionization imaging mass spectrometry (#MALDI IMS) enables detailed molecular mapping at cellular resolution. Check out the various mass analyzers and instrumental configurations in this new #Primer 🗺️ www.nature.com/articles/s43...
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Matrix-assisted laser desorption/ionization imaging mass spectrometry - Nature Reviews Methods Primers
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a label-free molecular imaging approach mapping diverse biomolecules at cellular resolution. In this Primer, Spragg...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 11/06/2026
This #PrimeView highlights the different applications afforded to cucurbituril macrocycles due to their molecular-scale recognition and binding selectivity. 🛟 www.nature.com/articles/s43...
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Cucurbit[n]uril-type molecular containers - Nature Reviews Methods Primers
This PrimeView highlights the different applications afforded to cucurbituril macrocycles due to their molecular-scale recognition and binding selectivity.
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 11/06/2026
#Cucurbiturils are synthetic macrocycles that serve as molecular containers. This #Primer from @lyleisaacs.bsky.social, @connor-r-schmidt.bsky.social, @cakakpo.bsky.social and team explores their synthesis and applications in chemical sensing, drug delivery. www.nature.com/articles/s43...
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Cucurbit[n]uril-type molecular containers - Nature Reviews Methods Primers
Cucurbit[n]urils are macrocyclic host molecules that form strong complexes with hydrophobic and cationic guests in water, where n is the number of glycoluril units. Cucurbit[n]urils complexed with gue...
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 04/06/2026
And check out the #PrimeView emphasizing the importance of correct data analysis for data generated using enzyme-tethering approaches for in situ epigenomics. www.nature.com/articles/s43...
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Enzyme tethering for in situ epigenomics - Nature Reviews Methods Primers
This PrimeView highlights the importance of correct data analysis for data generated using enzyme-tethering approaches for in situ epigenomics
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Nature Reviews Methods Primers @natrevmethodsprimers.nature.com · 04/06/2026
In this #Primer, a variety of #enzyme-tethering techniques, such as DamID, ChIC, CUT&RUN, CUT&Tag, and RT&Tag are highlighted, emphasizing their suitability for single-cell and spatial applications in biological research. 🪢🧬 www.nature.com/articles/s43...
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Enzyme tethering for in situ epigenomics - Nature Reviews Methods Primers
Enzyme-tethering epigenomic methods modify DNA while cells and nuclei remain intact, making them particularly suitable for single-cell and spatial applications. In this Primer, Kami Ahmad et al. discu...
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