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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 24/09/2026

Our OCTOBER ISSUE is live! Nutrient absorption & the small intestine, cytoskeleton and fibrogenesis, synthetic data in gastrointestinal medicine, cell therapies in IBD, and much more! www.nature.com/nrgastro/vol...

COVER: Regional organization of the small intestine, inspired by the Review starting on p741.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/08/2026

Our SEPTEMBER ISSUE is live! Pancreatic development, γδ T cells in CRC and liver cancer, precision nutrition in IBD, SLD in Latin America, and much more! www.nature.com/nrgastro/vol...

COVER: Pancreatic development, inspired by the Review starting on p674.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 03/08/2026

Our AUGUST ISSUE is live! Gut-brain axis, portal hypertension and HCC in cirrhosis, autoimmune gastritis, cytochrome P450 oxidoreductase in MASLD, and much more! www.nature.com/nrgastro/vol...

COVER: Gut–brain signalling, inspired by the Review starting on p608.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 30/06/2026

Our JULY ISSUE is live! Microplastics and the liver, SLD prevention and management, colitis-associated CRC, microbiome and host metabolic health, and much more! www.nature.com/nrgastro/vol...

COVER: Microplastics, nanoplastics and the liver, inspired by the Perspective starting on p585.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/06/2026

Our JUNE ISSUE is live! Therapeutic targets for MASH, metabotherapy for intestinal disease, germiline mutations and somatic mosaicism in SLD-related liver cancer, artificial intelligence in IBD, and much more! www.nature.com/nrgastro/vol...

COVER: Putting steatotic liver disease on a global stage, inspired by the Comment starting on p449.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 30/04/2026

Our MAY ISSUE is live! Consensus statement on gut health, dietary proteins and colonic disease, cholesterol metabolism, acute-on-chronic liver failure, and much more! www.nature.com/nrgastro/vol...

COVER: Defining gut health, inspired by the Consensus Statement starting on p432.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 31/03/2026

Our APRIL ISSUE is live! Preclinical models in MASLD-HCC, mucosal glycans and IBD, necrosis in liver inflammation and cancer, public health policies for SLD screening, and much more! www.nature.com/nrgastro/vol...

Models of MASLD and MASLD-HCC, inspired by the Review starting on p286.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/03/2026

Our MARCH ISSUE is live! Surgery in HCC, abdominal pain in IBD, WNT–β-catenin signalling in HCC, liver disease and HIV infection, and much more! www.nature.com/nrgastro/vol...

COVER: Improving surgery for liver cancer, inspired by the Review starting on p208.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: Gastric cancer in 2025 "Redefining gastroesophageal junction cancer care with perioperative immunotherapy, minimal residual disease monitoring and new targets" www.nature.com/articles/s41... #Oncsky

Current breakthroughs include perioperative immunotherapy, HER2-directed therapy sequencing and a decisive shift towards biomarker-driven treatment.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: Viral hepatitis in 2025 "Novel insights into chronic HBV infection" www.nature.com/articles/s41... #Hepsky #Liversky

Fig. 1: Diagram illustrating the risk of hepatocellular carcinoma attributable to chronic hepatitis B infection and strategies to mitigate it.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: IBD in 2025 "The 3 Ps of IBD today — prevention, pre-diagnosis and participation" www.nature.com/articles/s41... #Gastrosky

Fig. 1: Trends in IBD care 2025: from prevention to early intervention.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: Pancreatic cancer in 2025 "Pancreatic cancer: advances in immunology, translational analyses and therapeutic paradigms" www.nature.com/articles/s41... #Oncsky

" long-term data on personalized neoantigen vaccine approaches in resected pancreatic adenocarcinoma, detailed clinico-genomic analyses of large clinical trial datasets, and therapeutic strategies for early-stage disease"

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: MASLD in 2025 "Heart–liver co-management in MASLD: from concept to clinical practice" www.nature.com/articles/s41... #Liversky

Fig. 1: Key milestones in heart–liver co-management of MASLD.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

FEBRUARY ISSUE | YEAR IN REVIEW: Gut microbiota in 2025 "Pushing the frontier of gut microbiome health cross-kingdom and cross-organ" www.nature.com/articles/s41... #Microsky

Fig. 1: Roles of the gut multi-kingdom microbiome in regulating the homeostasis and disease susceptibility of intestinal and extraintestinal organs.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 02/02/2026

Our February ISSUE is live! Year in Review 2025, gut virome, gut-brain axis, liver-brain axis, cancer registries in Africa, and much more! www.nature.com/nrgastro/vol...

Looking back on 2025, inspired by the Year in Reviews starting on p112.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | Our Featured ROADMAP is on "Towards a reference cell atlas of liver diversity over the human lifespan" www.nature.com/articles/s41... #Liversky

Fig. 2: Methods for single-cell analyses to build an atlas for healthy human liver cells.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | REVIEW "Proteases in intestinal health and disease" www.nature.com/articles/s41... #Gastrosky

Fig. 3: Role of proteases in gut physiology.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | CONSENSUS STATEMENT "Cholangiocarcinoma 2026: status quo, unmet needs and priorities" www.nature.com/articles/s41... #Liversky #Oncsky

Fig. 2: Cholangiocarcinoma mortality worldwide.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | REVIEW "Advances in liver and pancreas organoids: how far we have come and where we go next" www.nature.com/articles/s41... #Liversky #Gastrosky

Fig. 2: Pancreas organoids derived from different tissue-resident cells.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | REVIEW "IL-1 family of cytokines in gastrointestinal and liver disorders" www.nature.com/articles/s41... #Gastrosky #Liversky

Fig. 1: IL-1 family members have a pivotal role in inflammation of the gastrointestinal tract.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | NEWS & VIEWS "Rethinking B cells in ulcerative colitis: a CAR T cell opportunity" www.nature.com/articles/s41... #Gastrosky

Fig. 1: Mechanistic rationale and process of CD19 CAR T cell therapy in ulcerative colitis.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | RESEARCH HIGHLIGHT "GWAS on idiopathic achalasia" www.nature.com/articles/s41... #Gastrosky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | RESEARCH HIGHLIGHT "Fibroblast spatial heterogeneity in Crohn’s disease fistulae" www.nature.com/articles/s41... #Gastrosky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | RESEARCH HIGHLIGHT "Optimizing sacral nerve stimulation to relieve chronic constipation" www.nature.com/articles/s41... #Gastrosky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE | RESEARCH HIGHLIGHT "SOLSTICE: tobevibart plus elebsiran for hepatitis D" www.nature.com/articles/s41... #Hepsky #IDsky #Liversky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

JANUARY ISSUE |COMMENT "The future of treating pancreatic exocrine insufficiency" www.nature.com/articles/s41... #Gastrosky

Table 1 Non-animal pancreatic enzyme preparations

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 05/01/2026

Our JANUARY ISSUE is live! Proteases and the gut, IL-1 cytokines, liver and pancreas organoids, cholangiocarcinoma, liver cell atlas and much more! www.nature.com/nrgastro/vol...

COVER: Liver cell atlas, inspired by the Roadmap on p97.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 19/12/2025

It is time for a well-deserved break for the Editorial team over the holidays - the editorial office will be closed from now until 5th January 🎄🎁☃️ Thanks to all our authors, referees and readers, it's been a fantastic year. Check out our wonderful covers! www.nature.com/nrgastro/vol... #gastrosky

All the monthly covers from Nature Reviews Gastroenterology & Hepatology in 2025

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 08/12/2025

REVIEW | Global burden of #hepatitisB virus: current status, missed opportunities and a call for action www.nature.com/articles/s41... Full-text link: rdcu.be/eTFsa This figure shows the care cascade of HBV infection and current gaps #HBV #NoHep #hepatitis #Liversky

Fig. 2: The care cascade of HBV infection and the current gaps

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | REVIEW "Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease" www.nature.com/articles/s41... #Liversky

Fig. 1: Areas for improving the definition of metabolic and alcohol-related liver disease (MetALD) for clinical trials.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | REVIEW "Interaction of inflammation and portal hypertension in cirrhosis progression" www.nature.com/articles/s41... #Liversky

Fig. 2: Organ-level consequences of portal hypertension (PH) and inflammation in cirrhosis.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | REVIEW "Multifaceted effects of the microbiome in pancreatic cancer: from association to modulation" www.nature.com/articles/s41... #Gastrosky #Microsky

Fig. 1: Role of microbiome modulation of immune function in pancreatic ductal adenocarcinoma (PDAC).

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | Our Featured REVIEW is on "Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment" www.nature.com/articles/s41... #Liversky

Fig. 3: Environmental cues modulating CD8+ tissue-resident memory T (TRM) cell phenotype and function.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE |NEWS & VIEWS "A neurobiotic sense curbs feeding: a new frontier in gut–brain communication" www.nature.com/articles/s41... #Gastrosky

Fig. 1: Neurobiotic sense of feeding control.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | RESEARCH HIGHLIGHT "Pharmacological management of obesity" www.nature.com/articles/s41... #Medsky

Research highlights:
- UEG Week 2025
- Predicting mortality in cirrhosis
- Metastasis and pericytes in oesophageal cancer
- Pharmacological management of obesity

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | RESEARCH HIGHLIGHT "Metastasis and pericytes in oesophageal cancer" www.nature.com/articles/s41... #Gastrosky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | RESEARCH HIGHLIGHT "Predicting mortality in cirrhosis" www.nature.com/articles/s41... #Liversky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE | RESEARCH HIGHLIGHT "UEG Week 2025" www.nature.com/articles/s41... #Gastrosky #Liversky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE |COMMENT "Submucosal electronics for long-term in situ diagnosis and therapeutics of gastrointestinal diseases" www.nature.com/articles/s41... #Gastrosky

Fig. 1: Submucosal electronics and their advantages in the gastrointestinal tract.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

DECEMBER ISSUE |COMMENT "Bezafibrate for primary biliary cholangitis: time to act on the evidence" www.nature.com/articles/s41... #Gastrosky

Fig. 1: Evidence for bezafibrate in second-line primary biliary cholangitis (PBC) treatment and the crucial questions it raises.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 25/11/2025

Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more! www.nature.com/nrgastro/vol...

COVER: ‘Jekyll and Hyde’ roles of memory T cells in the liver, inspired by the Review on p814.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | Our Featured PERSPECTIVE is on "Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI" www.nature.com/articles/s41... #Gastrosky #Microsky

Fig. 2: AI-integrated cycle of microbiome research, from hypothesis generation to therapeutic implementation.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | PERSPECTIVE "Large language models for clinical decision support in gastroenterology and hepatology" www.nature.com/articles/s41... #Gastrosky #Liversky

Fig. 2: Stages of clinical decision making and opportunities for LLM-based decision support.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | REVIEW "Parental diet and offspring health: a role for the gut microbiome via epigenetics" www.nature.com/articles/s41... #Gastrosky #Microsky

Fig. 3: Epigenetic effects of maternal dietary intake.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | REVIEW "Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease" www.nature.com/articles/s41... #Gastrosky

Fig. 2: Epithelial–stromal remodelling during intestinal regeneration.

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE |JOURNAL CLUB "Diagnosing paediatric coeliac disease" www.nature.com/articles/s41... #Gastrosky

"The strength of the AbCD study lies in its rigorous prospective design and multicentre enrolment"

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | RESEARCH HIGHLIGHT "Aspirin and recurrence of PI3K-mutated CRC" www.nature.com/articles/s41... #Gastrosky #Oncsky

Research Highlights:
NeuroGASTRO 2025
Maternal gut microbiome in early pregnancy: predictor of preterm birth?
Nivolumab and ipilimumab as neoadjuvant therapy for potentially resectable HCC
Aspirin and recurrence of PI3K-mutated CRC

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | RESEARCH HIGHLIGHT "Nivolumab and ipilimumab as neoadjuvant therapy for potentially resectable HCC" www.nature.com/articles/s41... #Liversky #Oncsky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | RESEARCH HIGHLIGHT "Maternal gut microbiome in early pregnancy: predictor of preterm birth?" www.nature.com/articles/s41... #Gastrosky #Microsky

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 27/10/2025

NOVEMBER ISSUE | RESEARCH HIGHLIGHT "NeuroGASTRO 2025" www.nature.com/articles/s41... #Gastrosky

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