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Nature Methods @natmethods.nature.com · 12h

NanoTS: deep learning-based tool for nanopore long-read transcriptome sequencing-based SNP detection and genotype calling. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 01/09/2026

In our August 'Points of View', @helenajambor.bsky.social and Alexander Lex discuss how to reuse, remix and vibe code scientific figures. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 06/08/2026

Our August issue is now live! 🥳 www.nature.com/nmeth/volume... On the cover, a network of neurons communicated via action potentials. Image from Aliphasha Vaziri, Life Science Editors, and Duygu Koldere Vilain. Paper: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 17/07/2026

We are thrilled to present our latest special issue, with a Focus on global science. Diversity in biological research and equitable access to technology is imperative for democratizing research. For a roadmap to the issue, please read our Editorial. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/07/2026

In our latest Points of View column, @helenajambor.bsky.social and Alexander Lex cover scientific web applications for creating biological data figures. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 12/06/2026

Our June issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope. Paper here: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/05/2026

Our May issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, volumetric label-free imaging of a live model of the human blood–brain barrier with a self-localized ultrafast pencil beam. Paper here: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 06/05/2026

A Perspective provides recommendations for open and sustainable AI and associated resources that facilitate exploration and implementation. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 06/05/2026

A Perspective provides a comprehensive framework for guiding intrinsically disordered protein ensemble determination, benchmarking and interpretation. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/04/2026

Our April issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, human-derived oligodendrocytes (blue nuclei) ensheath axon-mimetic hydrogel micropillars (green), forming myelin sheaths labeled by myelin basic protein (yellow). Paper: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 03/04/2026

3d-OT enables efficient alignment of heterogeneous multiomics tissue slices and spatial domain identification. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 13/03/2026

Our March issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, the Antscan database consists of detailed synchrotron microCT images of diverse ant species. Paper: www.nature.com/articles/s41... Image: Thomas van de Kamp, Karlsruhe Institute of Technology

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Nature Methods @natmethods.nature.com · 06/03/2026

Introducing Antscan, a public database of synchrotron X-ray CT images of 800 ant species. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 02/03/2026

DECODE: a universal deconvolution framework for transcriptomic, proteomic and metabolomic data. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 13/02/2026

Our February issue is now live! www.nature.com/nmeth/volume... On the cover, self-supervised reconstruction structured illumination imaging of VACV-induced actin comet tails. Paper here: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 04/02/2026

Not all scientific conferences offer childcare, but when they do, parents are happy. @vivienm.bsky.social asked conference attendees who are also mothers - and their children - about conference daycare. www.nature.com/articles/s41... and rdcu.be/e1y16

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Nature Methods @natmethods.nature.com · 14/01/2026

SpatialZ generates virtual single-cell transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/01/2026

Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/01/2026

Our January issue is now live! 🥳 nature.com/nmeth/volume... On the cover, a network of illuminated grids forms a cell-like shape representing Squidiff’s ability to predict continuous cell-state transitions under differentiation and perturbations. Paper: doi.org/10.1038/s415...

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Nature Methods @natmethods.nature.com · 09/01/2026

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 09/01/2026

SmartEM: a smart machine learning-based pipeline for electron microscopy-based data acquisition for connectomics. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 09/01/2026

TransBrain translates brain phenotypes between mouse and human via homology mapping. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 08/01/2026

DynamicAtlas: a morphodynamic atlas of Drosophila development. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 08/01/2026

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors, for tracking rapid dynamics and for recording from large populations of synapses. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 08/01/2026

A scalable, open source-framework can be used as a benchmarking suite for comparing macromolecular complex structure, interfaces and ligand interactions against experimental data. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 08/01/2026

CELTIC: a context-dependent deep learning model for in silico organelle localization in label-free microscopy images. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 18/12/2025

Self-supervised reconstruction structured illumination microscopy allows long-term imaging of cellular processes. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 18/12/2025

In this month's Creature Column, we feature the ascidian tunicate Ciona, a model for marine systems life sciences. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 18/12/2025

Scikit-bio: a Python library for biological omic data analysis. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/12/2025

RFdiffusion2 builds de novo enzyme active sites using atom-level functional group constraints. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/12/2025

CaBLAM: a bioluminescent, genetically encoded calcium indicator for high-contrast imaging in cells and in vivo. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/12/2025

Parallelized single-molecule fluorescence and FRET experiments enable quantitative analysis of molecule function from multiple samples in a single experiment. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/12/2025

ROSE-3D is a single-molecule localization microscopy method with high isotropic resolution, for whole-cell and multicolor imaging. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/12/2025

An Analysis benchmarks 50 state-of-the-art TCR-epitope binding prediction methods. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 04/12/2025

Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 03/12/2025

This Resource provides a multi-omic tissue atlas of aging in nonhuman primates. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 13/11/2025

Our November issue is now live! 🎉 www.nature.com/nmeth/volume... On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 30/10/2025

High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 14/10/2025

Our latest Creature Column features the gray mouse lemur, a model for primate brain evolution, cognition, aging and neurodegenerative diseases. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 10/10/2025

Our October issue is live! 🥳 www.nature.com/nmeth/volume... On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 03/10/2025

Laser ablation of imaged surface layers under adaptive control enables volumetric imaging of heterogeneous tissue like skull and brain. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 19/09/2025

We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 17/09/2025

A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/09/2025

CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 09/09/2025

Scvi-hub is a versatile and efficient platform for model-based analysis of single-cell sequencing studies with access to a diverse array of datasets and downstream analysis. @canergen.bsky.social www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 03/09/2025

Introducing TCAT, a pipeline to simultaneously capture gene expression programs related to T cell subsets and activation states. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 03/09/2025

SDR-seq is a droplet-based single-cell DNA-RNA sequencing platform for studying gene expression profiles linked to both noncoding and coding variants. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 13/08/2025

This month's Creature Column features the tubeworm Hydroides elegans - much maligned as a shipyard biofouling pest, but also a useful model organism for studying development, biomineralization and marine microbiology. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 11/08/2025

MAPIT-seq is an antibody-guided RNA editing method for co-profiling RBP-RNA interactions and gene expression in single cells and tissue. www.nature.com/articles/s41...

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Nature Methods @natmethods.nature.com · 07/08/2025

A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social www.nature.com/articles/s41...

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