iiinova — where your digital self keeps evolving

Nature Cardiovascular Research @natcardiovascres.nature.com · 01/04/2026

❤️Our March issue is out❤️Read about an AI model using echocardiography images improves cardiac diagnosis, LVAD unloading alleviates cellular senescence, inhibition of a hematopoietic death regulator shows cardioprotection, and more. www.nature.com/natcardiovas...

Image: Yuka Morikawa at The Texas Heart Institute at Baylor College of Medicine. Cover design: Francesca Corra

Microvascular senescence in single ventricle disease

Image shows IL6 expression in samples from individuals with hypoplastic left heart syndrome. Red denotes IL6; purple denotes endothelial cells; green denotes cardiac fibroblasts; white denotes cell boundaries; and blue denotes nuclei.

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Nature Cardiovascular Research @natcardiovascres.nature.com · 27/02/2026

❤️Our February issue is out❤️Read about self-powered stent for real-time monitoring, cardiomyocyte regeneration through glucocorticoid receptor antagonism, immunometabolic targeting for type 2 diabetic cardiomyopathy, and more. www.nature.com/natcardiovas...

Image: Jun Chen Laboratory, University of California, Los Angeles. Cover design: Bethany Vukomanovic

Magnetoelastic stent for restenosis diagnosis
Chen et al. describe a smart stent that combines mechanical support with continuous blood-flow sensing and demonstrate its functionality in vivo for restenosis diagnosis.

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Nature Cardiovascular Research @natcardiovascres.nature.com · 21/01/2026

21/01/2026 ❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more. www.nature.com/natcardiovas...

Image: Martin Dominguez, Drexel University, Irfan Kathiriya, University of California, San Francisco. Cover design: Bethany Vukomanovic

TBX5 sets boundaries for a healthy heart
Kathiriya et al. identify a Tbx5 + /Mef2cAHF + cardiac progenitor lineage that demarcates the interventricular septum during development, and changes in this lineage contribute to congenital heart defects in mice. (see Kathiriya et al.)

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Nature Cardiovascular Research @natcardiovascres.nature.com · 19/12/2025

Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event! www.youtube.com/watch?v=4wmn...

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Nature Cardiovascular Research @natcardiovascres.nature.com · 17/12/2025

❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more. www.nature.com/natcardiovas...

Image: Bethany Vukomanovic. Cover design: Bethany Vukomanovic

Genetic insights into long COVID
Human genetic analyses show that thromboembolism-related variants are associated with an increased risk of long COVID, suggesting shared pathogenic pathways and implicating the thrombin receptor PAR-1 as a potential contributor. (see Schuermans et al.)

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Nature Cardiovascular Research @natcardiovascres.nature.com · 13/11/2025

❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more. www.nature.com/natcardiovas...

Image: Leonardo Sacconi, Institute of Clinical Physiology. Cover design: Bethany Vukomanovic

Cardiac fibrosis and arrhythmia
Three-dimensional structural reconstruction of entire cleared mouse ventricles from a diseased heart acquired using mesoSPIM tomography. Myocardium is visualized by fluorescence (gray), and fibrosis is detected via scattered light (red) (see Giardini et al.).

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Nature Cardiovascular Research @natcardiovascres.nature.com · 15/10/2025

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.

Image: ScienceBrush Design. Cover design: Bethany Vukomanovic;

RNA editing in atherosclerosis:
Weldy et al. show that expression of the RNA-editing enzyme ADAR1 in smooth muscle cells regulates activation of the double-stranded RNA sensor MDA5, in a new model of atherosclerosis.

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Nature Cardiovascular Research @natcardiovascres.nature.com · 23/09/2025

❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more! www.nature.com/natcardiovas...

Image: Kathryn Berg. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · 13/08/2025

❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more! www.nature.com/natcardiovas...

Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · 15/07/2025

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! www.nature.com/natcardiovas...

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Nature Cardiovascular Research @natcardiovascres.nature.com · 23/06/2025

❤️Our June issue is out❤️Read about the insight from the LILACS trial on T-cell regulation in cardiology, empagliflozin’s role in protecting the kidney and preventing heart failure in the EMPACT-MI trial, and more! www.nature.com/natcardiovas...

Image: Georgios Rovas, École Polytechnique Fédérale de Lausanne, 2025. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · 19/05/2025

❤️Our May issue is out❤️Read our three articles focused on atherosclerosis, describing TLO-like structures within plaques, FDX1’s protective role, and how gut microbiota-derived bile acids suppress platelet activation, and more! www.nature.com/natcardiovas...

Image credit: Deqiang Kong, Yue Wang and Tianxing Yan. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · 15/04/2025

❤️Our April issue is out❤️ Read about sex differences in atherosclerosis revealed by single-cell sequencing, how cardiac motion can be generated from electrocardiogram readings, the cardiac side effects of targeting immune checkpoint regulators, and more! www.nature.com/natcardiovas...

Image: Atherosclerosis vessel: KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty; background: nobeastsofierce Science / Alamy Stock Photo. Cover design: Bethany Vukomanovic

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Nature Cardiovascular Research @natcardiovascres.nature.com · 11/04/2025

Research| Sukhavasi et al. reveal sex-specific differences in carotid stenosis. Deep single-cell sequencing shows distinct phenotypes in smooth muscle cells: osteogenic in females and chondrocytic in males, highlighting potential therapeutic targets.

A schematic illustrating the key stages and components of the overall study design.

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Nature Cardiovascular Research @natcardiovascres.nature.com · 31/03/2025

Research| Li, Ni, Wang et al. identify CD248+ fibroblasts as key players in cardiac fibrosis, promoting fibroblast-T cell interactions. Disrupting CD248-mediated pathways shows promise in reducing fibrosis and improving heart function. 👉https://rdcu.be/efPj0

a, UMAP of fibroblast subpopulations from different spatial positions of mouse hearts subjected to sham and MI (sham, 3 days and 28 days after infarction). n = 3 in each scRNA-seq group. b, Top marker genes expressed in each fibroblast subpopulation. c, Proportion of each fibroblast subpopulation in cardiac infarcted and remote zones at 3 days and 28 days after infarction. d, GO analysis of Cd248/Ackr3 F9 subset. e, Violin plots reflecting the Cd248 expression level in each fibroblast subpopulation (n = 15 animals). f, Violin plots reflecting the expression level of Cd248 in infarcted and remote zones at 3 days and 28 days after infarction with sham as control (n = 3 animals).

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