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Utilising multi-modal data-driven network analysis to identify monotherapy and combinational therapy targets in SOX2-dependent squamous cell lung cancer - Communications Chemistry
Understanding disease mechanisms is crucial for drug discovery, necessitating the integration of diverse and multi-modal data. Here, the authors develop iPANDDA, a network-based computational pipeline that integrates multi-modal data to predict drug targets for SOX2-dependent lung squamous cell carcinoma, identifying and validating key targets like AKT and mTOR complexes.