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Namrata

@namratan.bsky.social

Reposted by Namrata

Science Magazine @science.org · 13/12/2025

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA. Learn more in a new #SciencePerspective: scim.ag/3XKbhb6

scim.ag

A tale of two forms of cohesin in DNA repair

Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA

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Reposted by Namrata

The EMBO Journal @embojournal.org · 18/09/2026

How doe BRCA1 suppress Group 1 genomic tandem duplications? @ralphscully.bsky.social show that Brca1 coiled-coil mutant mouse models remain competent for suppression of tandem duplications despite being defective for homologous recombination link.springer.com/article/10.1...

link.springer.com

The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss - The EMBO Journal

BRCA1-linked cancers contain abundant ~10 kb ‘Group 1’ tandem duplications (TDs). Group 1 TDs form at a Tus/Ter replication-fork barrier in DNA-end resection-defective mouse embryonic stem (mES) cells...

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Reposted by Namrata

BIDMC Cancer Center @bidmc-cancercenter.bsky.social · 15/06/2026

❓ Do all BRCA1-mutant tumors develop the same way? Namrata Nilavar, PhD, Postdoc Fellow, BIDMC, presented her research at the 2026 @acscan.bsky.social Breakfast in Boston. Her work suggests distinct BRCA1 mutations may drive different patterns of genomic instability and tumor growth. #CancerResearch

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