iiinova — where your digital self keeps evolving

Michael T Wolfinger @mtwolfinger.bsky.social · 07/12/2025

ViennaRNA Package v2.7.1 is out! 🧬🎉 Solid update: smoother probing-informed folding (SHAPE/DMS), improved constraints handling, and nicer Python multistrand base-pair probs. Get: tbi.univie.ac.at/RNA/ Source: github.com/ViennaRNA/Vi... #ViennaRNA #RNA #ComputationalBiology #SHAPE #DMS #OpenSource

tbi.univie.ac.at

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Michael T Wolfinger @mtwolfinger.bsky.social · 30/07/2025

Calling #RNA & #Virology researchers! 🧬🦠 Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing. 📝 Original research & reviews welcome! 🗓️ Deadline: Feb 28, 2026 michaelwolfinger.com/blog/2025/bl... #FunctionalRNA #RNAstructure

michaelwolfinger.com

Functional RNAs in Virology Special Issue

MDPI Viruses has launched a new open-access Special Issue on “Functional RNAs in Virology” to highlight recent advances in understanding how RNAs act as regulatory molecule in viral infection

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Michael T Wolfinger @mtwolfinger.bsky.social · 04/07/2025

Exploring RNA biology with Deep Learning Algorithms 🚀 Thrilled to guest-edit this OA collection in RNA Biology! 🧬🤖 Seeking cutting-edge work on: • AI-powered transcriptomics • RNA structure prediction • RNA–protein interaction models Submit by Nov 30 2025👇 think.taylorandfrancis.com/article_coll...

think.taylorandfrancis.com

Exploring RNA Biology with Deep Learning Algorithms

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Reposted by Michael T Wolfinger

Vikram Agarwal @vagar.bsky.social · 29/05/2025

Some exciting news! 🥳👍 finally dropped our open-source AI model to predict translation rates from mRNA sequences online for free academic use! Hope it's widely used among RNA scientists! Code: github.com/Sanofi-Publi...; Model: zenodo.org/records/1537...; Preprint: www.biorxiv.org/content/10.1...

github.com

GitHub - Sanofi-Public/RiboNN: RiboNN: predicting translation efficiencies from mRNA sequences

RiboNN: predicting translation efficiencies from mRNA sequences - Sanofi-Public/RiboNN

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Reposted by Michael T Wolfinger

Danny IncaRNAto @incarnatolab.bsky.social · 15/11/2024

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

t.co

https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

Incorporating modified bases into #RNA structure predictions can reveal striking changes in RNA functionality. For instance, using more than 600 #tRNA sequences from tRNAdb, we've shown how modified bases significantly impact predicted structures. #Bioinformatics #SyntheticBiology 7/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

If a loop lacks specific parameters, we substitute the unmodified counterpart as a fallback—making predictions more flexible and accurate. 🖥️ #NucleotideModifications #RNAComputing 6/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

What makes the #ViennaRNA Package unique? 🤔 We don't rely on a pre-compiled, complete set of energy parameters for modified bases. Instead, we use a mix of hard- and soft-constraints to adjust predictions where we have parameters. #RNAScience #RNABioinformatics 5/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including: #Inosine (I) #Pseudouridine (P) #N6-methyladenosine (m6A) #7-deaza-adenosine (7DA) #Nebularine (purine) #Dihydrouridine (D) #Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology 4/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

They play vital roles in regulating gene expression by influencing processes like splicing, stability, and translation. To truly understand cellular processes and disease mechanisms, we must explore how these modifications shape RNA structure and function. #ViennaRNA 3/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

#RNA molecules are incredibly versatile, and one way they showcase this is through post-transcriptional modifications. These modifications expand the classic four-letter RNA alphabet (A, C, G, U) to include over 300 unique bases! 🌟 #RNAResearch #RNAEditing #LifeSciences 2/n

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Michael T Wolfinger @mtwolfinger.bsky.social · 18/01/2025

As my first post on Bluesky, I’d like to share something I recently posted on #LinkedIn about the incredible versatility of #RNA molecules and how #modifications expand their functionality. I’ll break it down into smaller posts here—let me know what you think! 🚀 1/n

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