Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aise…

Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. ...

Specialized immune cells called border-associated macrophages (BAMs) guard the brain’s outer tissues, where they help maintain homeostasis and protect against disease. In this review, Vara-Pérez and Movahedi explore how BAMs develop, how they can be classified, what roles they play, and why they matter for brain health. The authors integrate recent discoveries to highlight how BAMs support and defend the brain.

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macr…