iiinova — where your digital self keeps evolving

Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 29/03/2026

Idiopathic granulomatous mastitis was diagnosed after exclusion of infectious and autoimmune causes, with most patients managed by surgical oncology using antibiotics, steroids, and aspiration; long-term doxycycline reduced recurrence. ja.ma/4swgNf4

JAMA Dermatology "Research Letter: Diagnosis, Workup, and Treatment of Idiopathic Granulomatous Mastitis" by Isabel C. Yoon@1, Roxana Shirazi@2, Varshini Babu@1, et al. Published Online March 25, 2026. doi: 10.1001/jamadermatol.2026.0176

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 30/03/2026

This case report describes 2 otherwise healthy patients who presented with acquired idiopathic generalized anhidrosis and were treated with baricitinib. ja.ma/3NmdBne

The figure shows clinical and histopathologic images of a patient treated with Baricitinib. A and B are clinical images of the dorsal hand at presentation and after 16-wk treatment, respectively. C and D are anhidrotic and normohidrotic areas.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 01/04/2026

Individuals with #ChronicLymphocyticLeukemia faced increased risk of skin cancer-specific metastasis and death compared with controls especially #BasalCellCarcinoma and #SquamousCellCarcinoma, though the absolute risk remained low. ja.ma/47yZ8ev

Figure 1. Cumulative incidence curve showing 10-year standardized cumulative incidences and absolute risk differences for skin cancer. The graph plots the risk of skin cancer (%) over time since CLL diagnosis (years) for patients with CLL and controls.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 03/04/2026

📄 This case report describes large areas of erythema on the face, chest, and back with relatively clear boundaries and swollen hands with scattered skin-colored papules and nodules. ja.ma/41tiG0t

Close-up of two hands, palms up, showing signs of aging with wrinkled skin. Knuckles on each finger appear enlarged. The hands are placed on a plain surface, capturing skin texture and nail details.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 04/04/2026

This case report describes well-circumscribed, yellow-brown atrophic plaques on the legs that were rimmed by erythema and scale. ja.ma/41enuGJ

Figure 1. Clinical Image of Both Legs. Bilateral lower legs show well-defined atrophic yellow-brown plaques with mild scale.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 10/04/2026

A man in his 70s was admitted with a symptomatic impending rupture of a thoracic aortic aneurysm, followed by reticulate erythematous to violaceous macules that appeared on the dorsal & plantar surfaces of both feet. Take the Clinical Challenge: ja.ma/4tBSgVY

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 12/04/2026

#Sunscreen is essential for preventing sun damage, premature aging, & #SkinCancer. This JAMA Dermatology Patient Page provides a concise, dermatologist-approved guide to help you make the most of your sunscreen. ja.ma/4mgfsXJ

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Misha Rosenbach, MD @misharosenbach.bsky.social · 15/04/2026

“I would tell anybody over 50 years old to get the [shingles vaccine]," Haliburton said. Shingles vaccine is highly effective, (also data for reducing dementia). For dermatologists, important to know recs include not just >50, but age >18 who are immunosuppressed. www.espn.com/nba/story/_/...

espn.com

Pacers' Haliburton details frustrating battle with shingles

Pacers star Tyrese Haliburton opened up about his battle with shingles, saying it slowed the recovery of his torn Achilles.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 01/02/2026

Botulinum toxin injections were associated with high complete response rates for acute digital ischemia (93.1%), ischemic ulcers (90.1%), and gangrene (87.5%), with minimal adverse events. ja.ma/4rqaCs9

Digital gangrene before/after Botulinum Toxin A injections for Antineutrophil Cytoplasmic Antibody Vasculitis. Left hand at baseline with gangrene; right hand at baseline with gangrene. Left hand at follow-up; right hand at follow-up.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 05/02/2026

This case report describes a patient with a history of refractory acute myeloid leukemia who presented with white, spiny hyperkeratotic papules on his face and neck, and was subsequently diagnosed with trichodysplasia spinulosa. bit.ly/4tjXhDl

Figure 1. Clinical Image of Trichodysplasia spinulosa. Images show 'Before treatment' on the left, with spiky growths around the mouth, and 'After treatment' on the right, showing a smoother skin texture.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 06/02/2026

📄 This case report describes large areas of erythema on the face, chest, and back with relatively clear boundaries and swollen hands with scattered skin-colored papules and nodules. bit.ly/3ZgXYQe

Figure 2. Clinical Image. Close-up of two aging hands with wrinkles and visible veins against a white background, showing signs of a skin condition or aging.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 11/02/2026

A woman in her 70s with rheumatoid arthritis who was receiving long-term immunosuppression (prednisolone and methotrexate) presented with a 6-month history of progressive papulonodules on her face and extremities. 📝 Take the Clinical Challenge: ja.ma/4buHnzH

Clinical image of hands showing bumps and skin changes. One hand has a bandage. Alongside, a Hematoxylin-eosin stain at 100x magnification reveals cellular detail. Scale bar measures @number um.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 12/02/2026

Among patients with juvenile dermatomyositis, intermittent intravenous methylprednisolone pulse plus mycophenolate mofetil led to complete clinical response and remission in 93% of patients after a median 36 months of follow-up. ja.ma/4bG4449

Disease activity score charts display CMAS, DAS(total, muscle, skin), time to clinical response, height/BMI z-scores, BMD z-scores, and blood glucose/triglyceride levels versus follow-up time. Trends show stabilization or changes in response over time.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 12/02/2026

A man in his 30s presented with a 2-month history of hair loss on the entire scalp and the lateral portions of both eyebrows. Results of the hair-pull test were negative. What is your diagnosis? ja.ma/4661hgW

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 13/02/2026

Anifrolumab treatment in #LupusErythematosus was associated with significant reductions in systemic and cutaneous disease activity, while SIGLEC-1 expression decreased alongside clinical improvement. ja.ma/4reY1YX

The figure shows changes in disease characteristics and SIGLEC-I expression in lupus patients treated with anifrolumab. It includes clinical scores, SIGLEC-1, treatment duration, and IFN-I gene score before and after IFNAR1 blockade(anifrolumab) treatment for Patient 1@1 to Patient 7@7.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 09/01/2026

Case report describes a patient in his 50s with immunoglobulin A vasculitis with monoclonal B-cell lymphocytosis who was successfully treated with zanubrutinib after failure of multiple treatments. ja.ma/49HVRuF

Dermatopathology photomicrographs and clinical images of Immunoglobulin Vasculitis Lesions, including Hematoxylin-eosin staining at different magnifications, and clinical images of bilateral forearms before and after treatment.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 15/01/2026

Activating #EGFR variants were identified in early-onset, severe generalized #AcanthosisNigricans with pulmonary nodules; EGFR inhibitor therapy improved both skin and lung disease. ja.ma/4bw0Rnp

The image shows clinical features of a patient with Germline Epidermal Growth Factor Receptor L858R Variants. (A) Clinical image of case patient 1, (B) Palmoplantar keratoderma, (C) Leukonychia, (D) Woolly hair.

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 15/01/2026

A 20-year-old woman presented with 9 days of pain and decreased vision in the right eye, as well as 2 weeks of a rash and gum swelling. Fever, dyspnea, and hemoptysis developed. Read the full case details: nej.md/45acJaR #MedSky #DermSky #Ophthalmology

Images in Clinical Medicine
Granulomatosis with Polyangiitis

Panels A–C: Photos of the patient's legs, mouth, and eye.
Panels D–E: Friable, hemorrhagic nasopharyngeal mucosa and edematous, ulcerated laryngeal mucosa seen on endoscopy.
Panel F: CT of the chest showing nodules in both lungs.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 25/12/2025

This case report describes a man in his 30s who presented for evaluation of a 3-week history of irritation, redness, and photophobia in both eyes. ja.ma/3KOUwsx

Close-up of a person's eyes showing bilateral conjunctival hyperemia. The whites of the eyes are visibly red and inflamed, surrounding the green irises. Text: "Figure 1. Photograph Obtained at the Initial Consultation Demonstrating Bilateral Conjunctival Hyperemia"

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 01/01/2026

Digital gangrene before and after botulinum toxin A injections in patient, with antineutrophil cytoplasmic antibody vasculitis. Left and right hand at baseline and follow-up. Hands show signs of improvement after injections.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 03/01/2026

Lamellar ichthyosis (LI) is a rare autosomal recessive disorder characterized by widespread, thick, platelike scales. This case report describes 2 siblings in their 20s with lamellar ichthyosis treated with acitretin and dupilumab. ja.ma/45mH99S

Clinical photos show forearms and lower extremities of a patient with Lamellar Ichthyosis before and after treatment. A and B display forearms/legs at baseline with hyperpigmentation. C and D show forearms/legs post-treatment with reduced scaling.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 07/01/2026

A woman in her 70s presented with a 5-year history of pruritic, thickened plaques involving the trunk and extremities. Despite intermittent treatment with antihistamines and glucocorticoids, the condition progressed. Read the full case report: ja.ma/49kbXJD

Figure. Clinical Manifestation: "B" Lower extremities. The image shows legs and feet with visible skin abnormalities, including bumps and scaly patches, set against a dark background.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 08/01/2026

An adolescent female presented with 3 days of progressive abdominal pain and reported that a rash first appeared nearly 1 year earlier on her left wrist and gradually spread over several weeks. What is your diagnosis? ja.ma/4qItEcH

Image shows a clinical image of an abdomen with porcelain-white papules, and a hematoxylin-eosin stain. Text states: "Clinical image of abdomen", "Hematoxylin-eosin stain", and a description of the papules and biopsy results.

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 24/12/2025

A 38-year-old woman presented with a 12-month history of annular plaques on the forehead, cheeks, and neck. Skin biopsy revealed noncaseating epithelioid granulomas with sparse lymphocytic infiltration in the superficial dermis. Read the full case details: nej.md/3L26Llk #MedSky #DermSky #PulmSky

Images in Clinical Medicine
Cutaneous Sarcoidosis with Annular Plaques

Photos of the brownish-red annular plaques with a thinly raised border and central hypopigmentation with slight atrophy in areas on the forehead (Panel A), as well as on the cheeks and neck (Panel B).

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 07/01/2026

An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO @i-med.ac.at #MedSky #DermSky

Images in Clinical Medicine
Periumbilical Erythema Migrans

Panel A: A photo of the periumbilical erythema and a small gray protrusion in the umbilicus.
Panels B and C: Photos of a tick being extracted from the umbilicus.

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Reposted by Misha Rosenbach, MD

Ed Maibach @maibached.bsky.social · 06/01/2026

So little was known 18 years ago when I started researching climate comms. I'm blown away by how much we now know. This study, led by the incomparable Jan Voelkel with his all-star band, and released today in @natclimate.nature.com confirms that many distinct message strategies can work...

nature.com

A registered report megastudy on the persuasiveness of the most-cited climate messages - Nature Climate Change

How to effectively communicate climate change to the public has long been studied and debated. Through a registered report megastudy, researchers tested the ten most-cited climate change messaging str...

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Reposted by Misha Rosenbach, MD

Shematologist, MD @shematologist.medsky.social · 06/01/2026

This is purpura fulminans, a severe complication of meningitis (which as of today is no longer on our universal vaccine schedule) Micro clots & bleeding into the skin cause skin & tissue death. It’s more common in kids & associated with 20-70% mortality. Those who survive often lose limbs.

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Reposted by Misha Rosenbach, MD

Mark D. Levine @marklevinenyc.bsky.social · 23/12/2025

Year 1 data on congestion pricing in Manhattan… * Vehicle traffic: -11% * Foot traffic: +3.4% * Storefront vacancy: -0.9% * Pollution: -22% * Revenue for mass transit: $548M So YES this has been a huge success.

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Reposted by Misha Rosenbach, MD

Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 23/12/2025

The US #measles count for this year has topped 2,000 cases for the first time since 1992. These are confirmed cases only, ie there have been more. 3 reported deaths. The vast majority of the cases are in unvaccinated kids & adults. 11% needed hospitalization. www.cdc.gov/measles/data...

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 19/12/2025

In a Review Article on measles, Lien Anh Ha Do, MD, PhD, and Kim Mulholland, MB, BS, MD, review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies. Read the full review: nej.md/4lmC1Ir #MedSky #PedSky #IDSky

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 19/12/2025

A 72-year-old woman presented with a 3.5-month history of an enlarging, painless lump on her cheek. Examination showed a dome-shaped, reddish nodule on the left cheek, with a shiny surface and central hemorrhagic crust. Read the full case details: nej.md/3MDwXU5 #MedSky #DermSky #Oncology

Images in Clinical Medicine
Merkel-Cell Carcinoma

Panel A: Photo of the dome-shaped, reddish nodule surrounded by erythema on the left cheek.

Panel B: A punch biopsy of the lesion revealing dermal infiltration by small, round, blue cells arranged in nests, as well as scant cytoplasm and hyperchromatic nuclei; mitoses were frequently observed.

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 21/12/2025

HPV vaccination could prevent most cervical cancers, but only 27% of eligible adolescent girls worldwide have received the vaccine. Data suggest that a single dose may be protective. Research findings from the ESCUDDO trial are summarized in a new Quick Take video. nej.md/3MFcHBr #MedSky #IDSky

A visual representation of the ESCUDDO trial, which examined whether a single dose of HPV vaccination could help to protect adolescent girls against most cervical cancers.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 17/12/2025

Monthly vixarelimab led to rapid and sustained improvement in pruritus and lesion severity for adults with #PrurigoNodularis, with no serious drug-related adverse events reported. ja.ma/4pOaUJ4

Line graph showing proportion of responders vs study week for prurigo nodularis treatment. Vixarelimab at 540mg, 360mg, and 120mg, plus a placebo, are tracked across double-blind and open-label extension periods.

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Reposted by Misha Rosenbach, MD

Katharine Hayhoe @katharinehayhoe.com · 17/12/2025

NCAR is quite literally our global mothership. Everyone who works in climate and weather has passed through its doors and benefited from its incredible resources. Dismantling NCAR is like taking a sledgehammer to the keystone holding up our scientific understanding of the planet. Unbelievable.

usatoday.com

Trump moves to dismantle major US climate research center in Colorado

The Trump administration is breaking up the National Center for Atmospheric Research, taking aim at one of the world's leading climate research labs.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 13/12/2025

Digital gangrene before and after treatment. Top: left and right hands at baseline, showing gangrene on fingertips. Bottom: left and right hands post-treatment; improved condition of fingertips is shown.

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Reposted by Misha Rosenbach, MD

the JID Journal @thejidjournal.bsky.social · 11/12/2025

A report by Chloé Grolleau et al., "Single-cell profiling of lichen planus reveals type I interferon response triggering the interface dermatitis reaction" doi.org/10.1016/j.jid.2025.04.043 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 11/12/2025

Case Record of the MGH: A 5-year-old boy was admitted to the hospital because of fever and rash. Nonblanching papules spread from the feet to the legs, buttocks, lower back, arms, and ears. A diagnostic test was performed. Read the full case details: nej.md/4rV135I #MedSky #DermSky

Case Records of the Massachusetts General Hospital
A 5-Year-Old Boy with Fever and Rash

Clinical photographs

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 12/12/2025

A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. 1/2 #MedSky #DermSky

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Reposted by Misha Rosenbach, MD

the JID Journal @thejidjournal.bsky.social · 14/12/2025

A report by Moira Shea et al., "Prevalence of pyoderma gangrenosum: a systematic review and meta-regression analysis" doi.org/10.1016/j.jid.2025.05.030 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky

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Reposted by Misha Rosenbach, MD

the JID Journal @thejidjournal.bsky.social · 15/12/2025

A report by Muhammad Junejo et al., "JAK1 Inhibition is Sufficient for the Treatment of Granuloma Annulare" doi.org/10.1016/j.jid.2025.04.030 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky

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Reposted by Misha Rosenbach, MD

NBC News @nbcnews.com · 10/12/2025

The measles outbreak in South Carolina is “accelerating” with no end in sight following Thanksgiving and other large gatherings, state health officials say.

nbcnews.to

South Carolina measles outbreak is 'accelerating,' driving hundreds into quarantine

Some students who remain unvaccinated are now in a second 21-day quarantine since the beginning of the school year.

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Reposted by Misha Rosenbach, MD

Krutika Kuppalli, MD FIDSA @krutikakuppalli.bsky.social · 09/12/2025

🚨 Scientists detected a recombinant monkeypox virus combining Clade Ib & Clade IIb in a traveler from Asia to the UK. The virus continues to surprise us — this is what happens when transmission continues unchecked. Surveillance + data sharing matter more than ever. virological.org/t/inter-clad...

virological.org

Inter-Clade Recombinant Mpox Virus Detected in England in a Traveller Recently Returned from Asia

Inter-Clade Recombinant Mpox Virus Detected in England in a Traveller Recently Returned from Asia Authors: Steven T. Pullan1, Isobel Everall1, Rebecca Doherty1, Lucy Crossman1, Emma Wise1, Hassan Ha...

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 27/11/2025

A 5yo boy was admitted to the hospital because of fever and rash. Nonblanching papules spread from the feet to the legs, buttocks, lower back, arms, and ears. A diagnostic test was performed. What is the most likely diagnosis in this case? Cast your vote before Dec. 11: nej.md/3M2gY1C

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 29/11/2025

This case report describes a woman in her 30s with porcelain-white discoloration of all nails, which persisted under pressure, and a GJA1 mutation. ja.ma/4prvTRa

Close-up of two hands with leukonychia, a condition causing white discoloration of the nails. The nails on all fingers show distinct white patches against the natural nail bed.

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Reposted by Misha Rosenbach, MD

Alicia Ault @aliciaault.bsky.social · 26/11/2025

The SAFE Sunscreen Standards Act got slipped into the budget bill; is now law. It directs FDA to accept non-animal data, which removes what had been a major hurdle to sunscreen approvals in the US. My story for @medscape.com #Medsky #Dermsky #tanning #dermatology #sunsafety #skincancer #melanoma

medscape.com

Just-Signed Law Expected to Speed New Sunscreens to Market

Consumers in the US may finally have access to formulations and ingredients that have long been available in other countries.

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · 24/11/2025

A 75-year-old woman with a history of breast cancer treated with mastectomy of both breasts and adjuvant hormonal therapy presented with a 1-year history of a rash on her chest. Read the full case details: nej.md/47YGxI4 #MedSky #Oncology #DermSky

Images in Clinical Medicine
Cutaneous Metastases from Breast Carcinoma

Panel A: A photo of a cluster of papules on an erythematous base along the upper aspect of the surgical scar on the left chest wall.

Panel B: Histopathological analysis of a skin-biopsy sample obtained from the lesion along the superior aspect of the left chest-wall scar showing large, atypical cells within dermal lymphatic vessels.

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Reposted by Misha Rosenbach, MD

JAMA Dermatology @jamadermatology.com · 25/11/2025

Editorial: #Nicotinamide shows significant promise as a chemopreventive agent to reduce skin cancer risk in those with a history of the disease, advocating for its integration into routine secondary prevention alongside sun protection. ja.ma/4rqHguA

JAMA Dermatology editorial: "Nicotinamide for Skin Cancer Chemoprevention" by Sarah T. Arron, MD, PhD. Published online September 17, 2025. Includes links to author affiliations and article information.

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