Reposted by Gary MiramsNobel Prize @nobelprize.org · 05/10/2026BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” 241081514
Gary Mirams @mirams.bsky.social · 04/10/2026On a brand new East Midlands Aurora train. 1 inch cold steel window frame: just big enough to push into your arm, not big enough to rest your elbow on. Compare with a basic 1950s 3rd class rail carriage with carpeted/leather frame and arm rests. Doesn't feel like 75 years progress in comfort! 000
Reposted by Gary MiramsLondon Mathematical Society @londmathsoc.bsky.social · 02/10/2026💻🧪 Applications are open for our Computer Science Small Grants, where grants of up to £1,000 are available to support collaborative research at the interface of mathematics and computer science. Deadline: 8 October ➡️ www.lms.ac.uk/grants/compu... 012
Reposted by Gary MiramsRichard McElreath 🐈⬛ @rmcelreath.bsky.social · 25/09/2026Thoughts and prayers for research data managers everywhere. You are not alone. We will get through this together techcommunity.microsoft.com/blog/excelbl...techcommunity.microsoft.comExcel now supports multiple values in a single cell | Microsoft Community HubLists, arrays in cells, and nested arrays introduce new ways to store and organize related information, helping you keep data together without sacrificing... 2842186
Gary Mirams @mirams.bsky.social · 14/09/2026Interesting - would it be possible to use historic exchange rate fluctuations to estimate how much price entices/deters international tourists? 000
Gary Mirams @mirams.bsky.social · 08/09/2026Prepping my talk for #COMBINE2026 I revisited my "Vision of the Future" from 2014: mirams.wordpress.com/2014/04/02/a... it's still my target for what #IonChannel model development should look like. We've passed the 2025 setting of the story - maybe I'll add another decade ... or two! 🫣😅mirams.wordpress.comA vision of the futureJonathan Cooper and I have been working on a system for describing the simulation you would like to perform with a model*, in a way that is flexible enough to recreate the majority of possible expe… 001
Reposted by Gary MiramsarXiv q-bio.OT Other Quantitative Biology @qbioot-bot.bsky.social · 28/08/2026Shuttleworth, Lei, Farcot, Mirams: Conservative deterministic Markov models in mathematical biology: uniqueness of steady states, reversibility and computational methods arxiv.org/abs/2608.27252 arxiv.org/pdf/2608.27252 arxiv.org/html/2608.27252 011
Gary Mirams @mirams.bsky.social · 01/09/2026New preprint 🚨: doi.org/10.48550/arX... - some useful results on comparmental models (as used for ion channel modelling, amongst many other math bio applications) compiled into one place. You can only assume exponential decay solutions when model satisfies microscopic reversibility/detailed balance.doi.orgConservative deterministic Markov models in mathematical biology: uniqueness of steady states, reversibility and computational methodsOrdinary differential equations are commonly used throughout the sciences to build mechanistic models of time-dependent processes. Often, such models are Markov models describing the time-evolution of... 011
Reposted by Gary MiramsCell Physiology Workshop Liverpool @cpw-liverpool.bsky.social · 30/08/2026#CPW2026 is now over, but we're already planning for #CPW2027 🦑🧠🫀🔬 To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here: forms.cloud.microsoft/pages/respon... Please share the link with your electrophysiology trainees. 🙂 242
Reposted by Gary MiramsGlen O'Hara @gsoh31.bsky.social · 28/08/2026It's the Welsh universities that are by far the deepest in the mire. As presently constituted they simply have no chance. I wouldn't even know where to start now. Very sad and very stupid. www.timeshighereducation.com/news/wales-n...timeshighereducation.comWales needs ‘systemic reform’ as universities lose £100 millionCalls for regulator to act on subject review findings and better align education provision with nation’s needs, as six of its eight universities face deficits 12414
Reposted by Gary MiramsGlen O'Hara @gsoh31.bsky.social · 28/08/2026It's the Scottish (and even more so the Welsh) universities that one fears for most. As the system is configured now, they have no chance of continuing to provide good teaching and research. Many will not survive at all. www.bbc.co.uk/news/article...bbc.co.ukScotland's universities face 'bleak' future as £200m funding gap revealedA new report paints a 'bleak' picture of falling income from Scottish students and an over-reliance on international tuition fees. 21313
Reposted by Gary Miramsprofserious @profserious.bsky.social · 02/08/2026On Technical Education ... hard hat and graduation cap. Technical education merits greater recognition. But it is not the opposite of academic education. @profserious.bsky.social considers profserious.substack.com/p/on-technic...profserious.substack.comOn Technical Education... hard hat and graduation cap 053
Reposted by Gary MiramsJames Arnold @jamesarnold.bsky.social · 27/07/2026On bumping into Bill Oddie at the local North London recycling centre. Michael Palin’s Diary, 1998: 013132
Reposted by Gary MiramsAdam Golberg @cash4questions.bsky.social · 23/07/2026Me, going on about stuff again. 111
Gary Mirams @mirams.bsky.social · 23/07/2026At great @cacna1c.bsky.social "Connect #CACNA1C" meeting, Cardiff Met amazing families and heard about their struggles to figure out what channel variants do and how to treat Variant-specific in-silico models promising to assess risk and propose treatments timothysyndrome.org/conference/timothysyndrome.orgConnect CACNA1C Global Network Conference - Timothy Syndrome Alliance (TSA)Join researchers, healthcare professionals and families from all over the world to advance the understanding of CACNA1C 022
Reposted by Gary MiramsIan Dunt @iandunt.bsky.social · 23/07/2026It's funny how no-one ever asks where the money is coming from when you announce a cut in immigration. 392394535
Reposted by Gary MiramsJoshua Bull @joshuabull.bsky.social · 13/07/2026If you're at #ECMTB26 (or wish you were), you might be interested in our modelling paper out today in Plos Comp Biol! In which talented (ex-)student Nic Fan develops a #Chaste agent-based model to describe vascular remodelling in tumour growth models! journals.plos.org/ploscompbiol...journals.plos.orgExploring the relationship between vascular remodelling and tumour growth using agent-based modellingAuthor summary We have created an agent-based model (ABM) that accounts for mechanical interactions between tumour cells and associated vasculature. The model simulates vessel occlusion and pruning du... 1104
Gary Mirams @mirams.bsky.social · 30/06/2026🚨 postdoc job available! Fixed term postdoc position assessing the information added when pharma do animal studies, relative to lab and simulation based testing: www.linkedin.com/posts/garymi... Please repost!linkedin.comJob Vacancy at the University of Nottingham: Research Associate/Fellow (Fixed-Term) | Gary MiramsWe're hiring a postdoctoral statistician — come and help us reduce use of animals in drug safety testing 💊 : https://lnkd.in/gFjBpmvx Before a new drug reaches patients, its effect on the heart and ... 021
Gary Mirams @mirams.bsky.social · 26/06/2026A little blog post: #Claude #AI as a supercharged proofreader: mirams.wordpress.com/2026/06/26/c...mirams.wordpress.comClaude AI as a supercharged proofreaderIf you aren’t using LLMs like Claude (my favourite), ChatGPT, etc. as a proofreader for drafts of scientific papers or technical reports, you might want to give it a go…Claude likes to … 010
Reposted by Gary MiramsIan Dunt @iandunt.bsky.social · 24/06/2026Bit grim, but this is a very useful graph for why we are more likely than not to rejoin the EU. 46657136
Reposted by Gary MiramsNefarious Means @nefariousmeans.bsky.social · 24/06/2026Never did I think I would see a cure for sickle cell in my lifetime. A friend of mine in fifth grade died from this disease. My parents kept me home from the funeral because they thought I was too young to handle it. Modern science is a miracle. www.wafb.com/2026/06/23/n...wafb.comNew Orleans man becomes first in Louisiana functionally cured of sickle cell diseaseDaniel Cressy, 23, underwent gene therapy at Manning Family Children’s Hospital. 553209054476
Reposted by Gary MiramsRandall Munroe @xkcd.com · 24/06/2026Sports Commentary xkcd.com/3262/ 363497455
Reposted by Gary MiramsIan Dunt @iandunt.bsky.social · 19/06/2026God I love this country. We're just so ridiculous. 751524204
Reposted by Gary MiramsGlen O'Hara @gsoh31.bsky.social · 11/06/2026Today I've written for Arguably on one big mystery in our public life: why does no-one care about the existential crisis of our universities? Read all about it... 👇 www.arguably.uk/p/the-quiet-...arguably.ukThe quiet collapse of British universitiesOne of our great triumphs and economic advantages is fading away 312970
Reposted by Gary MiramsThe Royal Society @royalsociety.org · 01/06/2026Professor Mark Chaplain FRS is elected a Fellow of the Royal Society. He is an applied mathematician whose main area of research is mathematical oncology – the mathematical modelling of cancer – a field which he has pioneered since the early 1990s. #RSFellows bit.ly/4vfM4DZ 2111
Reposted by Gary MiramsMichael Okun @michael-okun.bsky.social · 10/06/2026I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇 5435871430
Reposted by Gary MiramsJudy Schmidt @geckzilla.bsky.social · 07/06/2026Two telescopes, two epochs, the same nebula. You might have to stare for a little bit to fully appreciate all the movement going. Apologies to any faint stars who got deleted. I tried to remove the NICMOS PSFs from the Hubble view (which is lower resolution/blurrier) 1221754
Gary Mirams @mirams.bsky.social · 03/06/2026Did I wake up in an alternative reality at some point? 000
Reposted by Gary Miramsprofserious @profserious.bsky.social · 24/05/2026On Choosing an Academic Career … what it takes, what it offers, and what it demands profserious.substack.com/p/on-choosin... by @profserious.bsky.social #HigherEducation #Universitiesprofserious.substack.comOn Choosing an Academic Career… what it takes, what it offers, and what it demands 1104
Gary Mirams @mirams.bsky.social · 20/05/2026I predicted 10 out of 17 studies correctly in Guess the Replication, reaching the rank of "Reviewer 2"! Can you do better? Play here: t1p.de/guther #GuessTheReplicationt1p.deGuess the Replication 000
Gary Mirams @mirams.bsky.social · 16/05/2026Steam loco royalty visiting Nottingham Transport Heritage Centre this weekend. Kids loved the Flying Scotsman footplate visit - with exit through the corridor tender too - plus a train ride pulled by Tornado. I loved it even more. 020
Reposted by Gary MiramsDuille @duille.com · 12/05/2026Design legend Margaret Calvert is 90 today. Look at that cake! If you've ever admired a road, rail or metro sign in Britain it's likely she had something to do with it. One of Britain's design heroes - happy birthday to her. Photo by: @oshgallerylondon (IG) Cake by: mybaker.co 201695475
Gary Mirams @mirams.bsky.social · 06/05/2026Due to #Microsoft price hikes our uni have started archiving #Office365 things >90 days old. Emails and calendar items go into an archive. To-do list (to-do.office.com) items disappear into the ether, never to be seen again. Sorry if I owe something you told me about >90 days ago. It is gone.to-do.office.comMicrosoft To DoMicrosoft To Do 110
Gary Mirams @mirams.bsky.social · 30/04/2026Hominins built with wood 476,000 years ago www.nature.com/articles/d41...nature.comHominins built with wood 476,000 years agoAncient hand-crafted wooden structures excavated in Zambia. 000
Reposted by Gary MiramsEuropean Research Council (ERC) @erc.europa.eu · 29/04/2026NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes: link.europa.eu/TBqRQJlink.europa.euERC Scientific Council readjusts rules for reapplicationThe ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ... 1173116
Reposted by Gary MiramsJames Briscoe @jamesbriscoe.bsky.social · 28/04/2026John Gurdon (1933-2025) by Jim Smith journals.biologists.com/dev/article/...journals.biologists.comJohn Gurdon (1933-2025)John Gurdon was a towering figure in developmental biology, respected and admired throughout the world. His discovery, made when he was a PhD student, that the nuclei of differentiated cells retain th... 1187
Reposted by Gary MiramsWellcome Trust @wellcometrust.bsky.social · 22/04/2026Curious about how we assess grant applications? We’re inviting researchers to observe a Wellcome funding advisory committee in action. Apply by 11 May 2026 ⤵️ wellcome.org/research-fun...wellcome.orgApply to observe a Wellcome funding advisory committee | Prepare to Apply | WellcomeFind out how to observe a Wellcome funding advisory committee. Researchers who are considering applying for Wellcome funding in the next two years can apply to observe a shortlisting committee. 063
Reposted by Gary MiramsDarren Dahly @statsepi.bsky.social · 03/02/2026Don't you f**king dare. 3134779
Gary Mirams @mirams.bsky.social · 08/04/2026...which can be used in optimisation or inference schemes like MCMC where thousands of action potentials at different parameter values are required, reducing the computation time by up to 70%. Open source Julia code provided. 🧵6/6 (very nice copyediting in Physica D with marked up LaTeX changes 😀) 011
Gary Mirams @mirams.bsky.social · 08/04/2026..including a novel "Noble 1962 with added concentrations" to use as a toy model, but also the Dutta et al. (CiPA version of the O'Hara model) which is a modern complex ODE system. The result is substantially faster calculation of limit cycles under parameter perturbations... 🧵5/6 100
Gary Mirams @mirams.bsky.social · 08/04/2026...BUT there is another way to get the limit cycle. Once you've computed one, you can use 'continuation methods' to explore how this solution changes as a function of parameters, in this paper we get this working for electrophysiology models for the first time (we think?)... 🧵4/6 100
Gary Mirams @mirams.bsky.social · 08/04/2026...this is usually the most relevant physiological behaviour to fit to data. Simulating all the way to a relatively good numerical approximation of the limit cycle usually involves solving ODEs for thousands of paces (millions of timesteps). Wrapped in an optimiser? Billions!....🧵3/6 100
Gary Mirams @mirams.bsky.social · 08/04/2026... when doing electrophysiology simulations there are 'slowly changing' variables - usually concentrations - that take hundreds or even thousands of paces to settle down to a steady response. In dynamical systems parlance this steady response is a stable periodic orbit or "limit cycle"....🧵2/6 100
Gary Mirams @mirams.bsky.social · 08/04/2026🚨 Latest paper out now 🚨 by @mattjowen.bsky.social and me: "Continuation methods as a tool for parameter inference in models of biological oscillations: A case study in electrophysiology modeling" in doi.org/10.1016/j.ph... short tweetorial follows ..... 🧵1/6 100
Gary Mirams @mirams.bsky.social · 08/04/2026...BUT there is another way to get the limit cycle. Once you've computed one, you can use 'continuation methods' to explore how this solution changes as a function of parameters, in this paper we get this working for electrophysiology models for the first time (we think?)... 🧵4/6 000
Gary Mirams @mirams.bsky.social · 08/04/2026...this is usually the most relevant physiological behaviour to fit to data. Simulating all the way to a relatively good numerical approximation of the limit cycle usually involves solving ODEs for thousands of paces (millions of timesteps). Wrapped in an optimiser? Billions!....🧵3/6 100