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Gary Mirams

@mirams.bsky.social
169 followers 166 following 116 posts

Prof. of Mathematical Physiology, University of Nottingham. Like: rambling, scrambling, climbing, surfing, Irish trad music, VW vans.

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Reposted by Gary Mirams
Nobel Prize @nobelprize.org · 05/10/2026
BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Gary Mirams @mirams.bsky.social · 04/10/2026
On a brand new East Midlands Aurora train. 1 inch cold steel window frame: just big enough to push into your arm, not big enough to rest your elbow on. Compare with a basic 1950s 3rd class rail carriage with carpeted/leather frame and arm rests. Doesn't feel like 75 years progress in comfort!
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London Mathematical Society @londmathsoc.bsky.social · 02/10/2026
💻🧪 Applications are open for our Computer Science Small Grants, where grants of up to £1,000 are available to support collaborative research at the interface of mathematics and computer science. Deadline: 8 October ➡️ www.lms.ac.uk/grants/compu...
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Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 25/09/2026
Thoughts and prayers for research data managers everywhere. You are not alone. We will get through this together techcommunity.microsoft.com/blog/excelbl...
techcommunity.microsoft.com
Excel now supports multiple values in a single cell | Microsoft Community Hub
Lists, arrays in cells, and nested arrays introduce new ways to store and organize related information, helping you keep data together without sacrificing...
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Gary Mirams @mirams.bsky.social · 14/09/2026
Interesting - would it be possible to use historic exchange rate fluctuations to estimate how much price entices/deters international tourists?
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Gary Mirams @mirams.bsky.social · 08/09/2026
Prepping my talk for #COMBINE2026 I revisited my "Vision of the Future" from 2014: mirams.wordpress.com/2014/04/02/a... it's still my target for what #IonChannel model development should look like. We've passed the 2025 setting of the story - maybe I'll add another decade ... or two! 🫣😅
mirams.wordpress.com
A vision of the future
Jonathan Cooper and I have been working on a system for describing the simulation you would like to perform with a model*, in a way that is flexible enough to recreate the majority of possible expe…
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Reposted by Gary Mirams
arXiv q-bio.OT Other Quantitative Biology @qbioot-bot.bsky.social · 28/08/2026
Shuttleworth, Lei, Farcot, Mirams: Conservative deterministic Markov models in mathematical biology: uniqueness of steady states, reversibility and computational methods arxiv.org/abs/2608.27252 arxiv.org/pdf/2608.27252 arxiv.org/html/2608.27252
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Gary Mirams @mirams.bsky.social · 01/09/2026
New preprint 🚨: doi.org/10.48550/arX... - some useful results on comparmental models (as used for ion channel modelling, amongst many other math bio applications) compiled into one place. You can only assume exponential decay solutions when model satisfies microscopic reversibility/detailed balance.
doi.org
Conservative deterministic Markov models in mathematical biology: uniqueness of steady states, reversibility and computational methods
Ordinary differential equations are commonly used throughout the sciences to build mechanistic models of time-dependent processes. Often, such models are Markov models describing the time-evolution of...
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Cell Physiology Workshop Liverpool @cpw-liverpool.bsky.social · 30/08/2026
#CPW2026 is now over, but we're already planning for #CPW2027 🦑🧠🫀🔬 To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here: forms.cloud.microsoft/pages/respon... Please share the link with your electrophysiology trainees. 🙂
Students & demonstrators in the lab, CPW August 2026
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Glen O'Hara @gsoh31.bsky.social · 28/08/2026
It's the Welsh universities that are by far the deepest in the mire. As presently constituted they simply have no chance. I wouldn't even know where to start now. Very sad and very stupid. www.timeshighereducation.com/news/wales-n...
timeshighereducation.com
Wales needs ‘systemic reform’ as universities lose £100 million
Calls for regulator to act on subject review findings and better align education provision with nation’s needs, as six of its eight universities face deficits
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Glen O'Hara @gsoh31.bsky.social · 28/08/2026
It's the Scottish (and even more so the Welsh) universities that one fears for most. As the system is configured now, they have no chance of continuing to provide good teaching and research. Many will not survive at all. www.bbc.co.uk/news/article...
bbc.co.uk
Scotland's universities face 'bleak' future as £200m funding gap revealed
A new report paints a 'bleak' picture of falling income from Scottish students and an over-reliance on international tuition fees.
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Gary Mirams @mirams.bsky.social · 17/08/2026
Well done the #RedBarrows
When the red arrows couldn’t fly, Devon-based wheelbarrow performance group the “Red Barrows” stepped in to fill the void
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profserious @profserious.bsky.social · 02/08/2026
On Technical Education ... hard hat and graduation cap. Technical education merits greater recognition. But it is not the opposite of academic education. @profserious.bsky.social considers profserious.substack.com/p/on-technic...
profserious.substack.com
On Technical Education
... hard hat and graduation cap
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James Arnold @jamesarnold.bsky.social · 27/07/2026
On bumping into Bill Oddie at the local North London recycling centre. Michael Palin’s Diary, 1998:
Saturday, May 2nd

Various local chores – to the recycling depot. Bill Oddie's there. Draw his attention to a new bin for 'Spectacles'. He said one for 'Scripts' would do well round here.
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Adam Golberg @cash4questions.bsky.social · 23/07/2026
Me, going on about stuff again.
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Gary Mirams @mirams.bsky.social · 23/07/2026
At great @cacna1c.bsky.social "Connect #CACNA1C" meeting, Cardiff Met amazing families and heard about their struggles to figure out what channel variants do and how to treat Variant-specific in-silico models promising to assess risk and propose treatments timothysyndrome.org/conference/
timothysyndrome.org
Connect CACNA1C Global Network Conference - Timothy Syndrome Alliance (TSA)
Join researchers, healthcare professionals and families from all over the world to advance the understanding of CACNA1C
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Ian Dunt @iandunt.bsky.social · 23/07/2026
It's funny how no-one ever asks where the money is coming from when you announce a cut in immigration.
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Gary Mirams @mirams.bsky.social · 20/07/2026
...to highs not seen since Thursday afternoon
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Joshua Bull @joshuabull.bsky.social · 13/07/2026
If you're at #ECMTB26 (or wish you were), you might be interested in our modelling paper out today in Plos Comp Biol! In which talented (ex-)student Nic Fan develops a #Chaste agent-based model to describe vascular remodelling in tumour growth models! journals.plos.org/ploscompbiol...
journals.plos.org
Exploring the relationship between vascular remodelling and tumour growth using agent-based modelling
Author summary We have created an agent-based model (ABM) that accounts for mechanical interactions between tumour cells and associated vasculature. The model simulates vessel occlusion and pruning du...
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Gary Mirams @mirams.bsky.social · 30/06/2026
🚨 postdoc job available! Fixed term postdoc position assessing the information added when pharma do animal studies, relative to lab and simulation based testing: www.linkedin.com/posts/garymi... Please repost!
linkedin.com
Job Vacancy at the University of Nottingham: Research Associate/Fellow (Fixed-Term) | Gary Mirams
We're hiring a postdoctoral statistician — come and help us reduce use of animals in drug safety testing 💊 : https://lnkd.in/gFjBpmvx Before a new drug reaches patients, its effect on the heart and ...
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Gary Mirams @mirams.bsky.social · 26/06/2026
A little blog post: #Claude #AI as a supercharged proofreader: mirams.wordpress.com/2026/06/26/c...
mirams.wordpress.com
Claude AI as a supercharged proofreader
If you aren’t using LLMs like Claude (my favourite), ChatGPT, etc. as a proofreader for drafts of scientific papers or technical reports, you might want to give it a go…Claude likes to …
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Ian Dunt @iandunt.bsky.social · 24/06/2026
Bit grim, but this is a very useful graph for why we are more likely than not to rejoin the EU.
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Nefarious Means @nefariousmeans.bsky.social · 24/06/2026
Never did I think I would see a cure for sickle cell in my lifetime. A friend of mine in fifth grade died from this disease. My parents kept me home from the funeral because they thought I was too young to handle it. Modern science is a miracle. www.wafb.com/2026/06/23/n...
wafb.com
New Orleans man becomes first in Louisiana functionally cured of sickle cell disease
Daniel Cressy, 23, underwent gene therapy at Manning Family Children’s Hospital.
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Randall Munroe @xkcd.com · 24/06/2026
Sports Commentary xkcd.com/3262/
Comic. [A person and a second person with a ponytail sitting at a table with a screen showing a soccer game behind them.] PERSON 1: They could be in trouble. Over the last 36 years, they’ve gone 0 for 2 when they’ve scored in the 37th minute to lead 2-1 against a team whose country comes before theirs alphabetically. [caption] I wish sports commentators hadn’t discovered p-hacking.
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Gary Mirams @mirams.bsky.social · 20/06/2026
Strictly no smoking beyond this point, stuck to a gas canister
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Ian Dunt @iandunt.bsky.social · 19/06/2026
God I love this country. We're just so ridiculous.
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Glen O'Hara @gsoh31.bsky.social · 11/06/2026
Today I've written for Arguably on one big mystery in our public life: why does no-one care about the existential crisis of our universities? Read all about it... 👇 www.arguably.uk/p/the-quiet-...
arguably.uk
The quiet collapse of British universities
One of our great triumphs and economic advantages is fading away
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The Royal Society @royalsociety.org · 01/06/2026
Professor Mark Chaplain FRS is elected a Fellow of the Royal Society. He is an applied mathematician whose main area of research is mathematical oncology – the mathematical modelling of cancer – a field which he has pioneered since the early 1990s. #RSFellows bit.ly/4vfM4DZ
A photo of a man smiling in front of a colourful bookshelf.
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Michael Okun @michael-okun.bsky.social · 10/06/2026
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
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Judy Schmidt @geckzilla.bsky.social · 07/06/2026
Two telescopes, two epochs, the same nebula. You might have to stare for a little bit to fully appreciate all the movement going. Apologies to any faint stars who got deleted. I tried to remove the NICMOS PSFs from the Hubble view (which is lower resolution/blurrier)
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Gary Mirams @mirams.bsky.social · 03/06/2026
Did I wake up in an alternative reality at some point?
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profserious @profserious.bsky.social · 24/05/2026
On Choosing an Academic Career … what it takes, what it offers, and what it demands profserious.substack.com/p/on-choosin... by @profserious.bsky.social #HigherEducation #Universities
profserious.substack.com
On Choosing an Academic Career
… what it takes, what it offers, and what it demands
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Gary Mirams @mirams.bsky.social · 20/05/2026
I predicted 10 out of 17 studies correctly in Guess the Replication, reaching the rank of "Reviewer 2"! Can you do better? Play here: t1p.de/guther #GuessTheReplication
t1p.de
Guess the Replication
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Gary Mirams @mirams.bsky.social · 16/05/2026
Steam loco royalty visiting Nottingham Transport Heritage Centre this weekend. Kids loved the Flying Scotsman footplate visit - with exit through the corridor tender too - plus a train ride pulled by Tornado. I loved it even more.
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Reposted by Gary Mirams
Duille @duille.com · 12/05/2026
Design legend Margaret Calvert is 90 today. Look at that cake! If you've ever admired a road, rail or metro sign in Britain it's likely she had something to do with it. One of Britain's design heroes - happy birthday to her. Photo by: @oshgallerylondon (IG) Cake by: mybaker.co
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Gary Mirams @mirams.bsky.social · 06/05/2026
Due to #Microsoft price hikes our uni have started archiving #Office365 things >90 days old. Emails and calendar items go into an archive. To-do list (to-do.office.com) items disappear into the ether, never to be seen again. Sorry if I owe something you told me about >90 days ago. It is gone.
to-do.office.com
Microsoft To Do
Microsoft To Do
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Gary Mirams @mirams.bsky.social · 30/04/2026
Hominins built with wood 476,000 years ago www.nature.com/articles/d41...
nature.com
Hominins built with wood 476,000 years ago
Ancient hand-crafted wooden structures excavated in Zambia.
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European Research Council (ERC) @erc.europa.eu · 29/04/2026
NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes: link.europa.eu/TBqRQJ
link.europa.eu
ERC Scientific Council readjusts rules for reapplication
The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ...
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James Briscoe @jamesbriscoe.bsky.social · 28/04/2026
John Gurdon (1933-2025) by Jim Smith journals.biologists.com/dev/article/...
journals.biologists.com
John Gurdon (1933-2025)
John Gurdon was a towering figure in developmental biology, respected and admired throughout the world. His discovery, made when he was a PhD student, that the nuclei of differentiated cells retain th...
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Wellcome Trust @wellcometrust.bsky.social · 22/04/2026
Curious about how we assess grant applications? We’re inviting researchers to observe a Wellcome funding advisory committee in action. Apply by 11 May 2026 ⤵️ wellcome.org/research-fun...
wellcome.org
Apply to observe a Wellcome funding advisory committee | Prepare to Apply | Wellcome
Find out how to observe a Wellcome funding advisory committee. Researchers who are considering applying for Wellcome funding in the next two years can apply to observe a shortlisting committee.
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Darren Dahly @statsepi.bsky.social · 03/02/2026
Don't you f**king dare.
Screen shot of a youtube video titled "AI.FILL Function Explained: 10X Productivity in Excel with AI" with the caption "Let ChatGPT fill your missing data"
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Gary Mirams @mirams.bsky.social · 08/04/2026
...which can be used in optimisation or inference schemes like MCMC where thousands of action potentials at different parameter values are required, reducing the computation time by up to 70%. Open source Julia code provided. 🧵6/6 (very nice copyediting in Physica D with marked up LaTeX changes 😀)
Pairwise MCMC posterior samples from inference of parameters in our Noble1962-with-concentrations model.
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Gary Mirams @mirams.bsky.social · 08/04/2026
..including a novel "Noble 1962 with added concentrations" to use as a toy model, but also the Dutta et al. (CiPA version of the O'Hara model) which is a modern complex ODE system. The result is substantially faster calculation of limit cycles under parameter perturbations... 🧵5/6
box and whisker plot showing compution times for large and small parameter perturbations, using continuation methods versus standard ODE solving.
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Gary Mirams @mirams.bsky.social · 08/04/2026
...BUT there is another way to get the limit cycle. Once you've computed one, you can use 'continuation methods' to explore how this solution changes as a function of parameters, in this paper we get this working for electrophysiology models for the first time (we think?)... 🧵4/6
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Gary Mirams @mirams.bsky.social · 08/04/2026
...this is usually the most relevant physiological behaviour to fit to data. Simulating all the way to a relatively good numerical approximation of the limit cycle usually involves solving ODEs for thousands of paces (millions of timesteps). Wrapped in an optimiser? Billions!....🧵3/6
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Gary Mirams @mirams.bsky.social · 08/04/2026
... when doing electrophysiology simulations there are 'slowly changing' variables - usually concentrations - that take hundreds or even thousands of paces to settle down to a steady response. In dynamical systems parlance this steady response is a stable periodic orbit or "limit cycle"....🧵2/6
convergence of an action potential over time as a limit cycle in model state space
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Gary Mirams @mirams.bsky.social · 08/04/2026
🚨 Latest paper out now 🚨 by @mattjowen.bsky.social and me: "Continuation methods as a tool for parameter inference in models of biological oscillations: A case study in electrophysiology modeling" in doi.org/10.1016/j.ph... short tweetorial follows ..... 🧵1/6
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Gary Mirams @mirams.bsky.social · 08/04/2026
...BUT there is another way to get the limit cycle. Once you've computed one, you can use 'continuation methods' to explore how this solution changes as a function of parameters, in this paper we get this working for electrophysiology models for the first time (we think?)... 🧵4/6
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Gary Mirams @mirams.bsky.social · 08/04/2026
...this is usually the most relevant physiological behaviour to fit to data. Simulating all the way to a relatively good numerical approximation of the limit cycle usually involves solving ODEs for thousands of paces (millions of timesteps). Wrapped in an optimiser? Billions!....🧵3/6
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