iiinova — where your digital self keeps evolving

Michele Gabriele @michelegabriele.bsky.social · 20/05/2026

Thrilled to welcome @jpflores.rbind.io to the lab as a Fulbright U.S. Scholar! 🎉🇮🇹 JP will be joining us at SR-Tiget in Milan to dig deep into 3D genome dynamics and enhancer biology! Couldn't think of a better addition to the team. Fulbright + great science + Milan. See you soon, JP! 🧬

0112

Michele Gabriele @michelegabriele.bsky.social · 15/01/2026

With a bit of a delay, I’m very excited to welcome Anna Cavagnoli, the first PhD student of Gabriele Lab! lnkd.in/ddY5Y-bz 🎉🎉🎉 Anna is enrolled in the very first cycle of the Science and Technology for Advanced Therapies PhD program at the Scuola Universitaria Superiore Pavia!

020

Michele Gabriele @michelegabriele.bsky.social · 19/09/2025

Welcome to Sabrina Savoia and Ilaria Locatelli, the first members of the lab! We are officially operative! 🥳 gabrielelab.com/team

030

Michele Gabriele @michelegabriele.bsky.social · 18/07/2025

At SR-Tiget we are seeking outstanding mid-career scientists in Computational biology, AI, and Molecular immunology who wish to translate their results into therapeutic advances with a focus on genetic diseases! Deadline 1st September 2025! www.linkedin.com/posts/sr-tig...

linkedin.com

000

Michele Gabriele @michelegabriele.bsky.social · 23/06/2025

Are you a mid-career group leader in computational bio/AI/molecular immunology who wants to move the lab to Italy? (preferentially from USA?) The SR-TIGET (Milan, Italy) is recruiting someone like you! Here the call: back.fondazionetelethon.it/uploads/2025...

back.fondazionetelethon.it

043

Michele Gabriele @michelegabriele.bsky.social · 23/06/2025

Have you recently finished your PhD and had excellent productivity? Telethon foundation is starting a postdoctoral program with a competetive 3-years fully funded position! Send CV and PI preference (included me, I am not yet in the website) details here: back.fondazionetelethon.it/uploads/2025...

back.fondazionetelethon.it

010

Reposted by Michele Gabriele

matteomazzocca.bsky.social @matteomazzocca.bsky.social · 14/05/2025

3/ We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical

141

Michele Gabriele @michelegabriele.bsky.social · 15/05/2025

This new preprint from my labmates provides a new perspective on chromatin dynamics! Strongly suggested to everyone into chromatin given its broad impact!

010

Michele Gabriele @michelegabriele.bsky.social · 23/04/2025

I also want to thank all the amazing colleagues I met during these years and the MIT community for all the support, collaborations, scientific discussion, and new lasting friendship, without whose support, all of this would not have been possible!

010

Michele Gabriele @michelegabriele.bsky.social · 23/04/2025

For now, to hear more details, check the SR-Tiget post and interview! Now, approaching the end of my American Journey, I want to thank my postdoc mentor, Anders Sejr Hansen, who deeply supported me through the pandemic until the opening of my lab!

100

Michele Gabriele @michelegabriele.bsky.social · 23/04/2025

In the lab, we will investigate the role of chromatin regulation in development and diseases using a multidisciplinary approach! I will recruit at any level, so stay tuned for job openings, which will follow soon.

100

Michele Gabriele @michelegabriele.bsky.social · 23/04/2025

SR-Tiget is an excellence reality in Italy where fundamental and clinical research merge to create new gene therapy approaches, and I am honored to open my laboratory with them!

100

Reposted by Michele Gabriele

Ludovico Rizzuti @ludoritz.bsky.social · 03/04/2025

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs. Full paper here: www.biorxiv.org/content/10.1... Thread below 🧵

biorxiv.org

1143

Michele Gabriele @michelegabriele.bsky.social · 24/02/2025

Kudos to Marlene and Veronica who lead the experimental and computational part, and @alessandrovitriolo.bsky.social and Giuseppe with whom we shared the supervision! Special thanks to the families of individuals affected by Gabriele de-Vries syndrome who provided samples to generate #iPSCs

020

Michele Gabriele @michelegabriele.bsky.social · 24/02/2025

I'm proud to share that our modeling of #YY1 haploinsufficiency has just been published! www.nature.com/articles/s41... Using #organoids and #neurons we discovered that YY1 mutations affect the cross-talk between cells and also cause a non-cell autonomous phenotype in a cell-type specific manner.

nature.com

Article Metrics - YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs | Molecular Psychiatry

162

Michele Gabriele @michelegabriele.bsky.social · 19/01/2025

Starting 2025 with a genome architecture paper about absolute quantification of looped states, lead by James Jusuf!

040