iiinova — where your digital self keeps evolving

Reposted by Micha Müller

Peter Ly @peterlylab.bsky.social · 19/05/2026

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

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Reposted by Micha Müller

Marvin Tanenbaum @marvintanenbaum.bsky.social · 13/05/2026

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Micha Müller

Bram Verhagen @bramverhagen.bsky.social · 13/05/2026

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

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Reposted by Micha Müller

Hubrecht Institute @hubrechtinstitute.bsky.social · 16/02/2026

For the first time, scientists watched the flu virus live as it infected human airway cells. The group from @marvintanenbaum.bsky.social developed a new imaging technique, VISUN, and observed a large variation in infection success. See www.hubrecht.eu/flu-virus/. Video by @janinschoko.bsky.social

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Micha Müller @michamuller.bsky.social · 12/02/2026

Our paper on visualising influenza A virus in live cells with single viral RNA resolution is now out in Cell Systems 🥳 For more details about what we did, see the thread about the preprint below ⬇️

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Reposted by Micha Müller

Marvin Tanenbaum @marvintanenbaum.bsky.social · 28/01/2026

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW

rdcu.be

Pre-assembly of biomolecular condensate seeds drives RSV replication

Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

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Reposted by Micha Müller

Maximilian Madern @maxmadern.bsky.social · 20/01/2026

Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions. www.biorxiv.org/content/10.6...

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Reposted by Micha Müller

Arjun Raj @arjunraj.bsky.social · 14/11/2025

So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)! www.cell.com/cell/fulltex...

cell.com

Single-cell susceptibility to viral infection is driven by variable cell states

Not all cells that can be infected by a virus become infected with that virus. Single-cell clone tracing reveals intrinsic cell states with variable expression patterns that increase susceptibility to...

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Reposted by Micha Müller

Hubrecht Institute @hubrechtinstitute.bsky.social · 28/04/2025

It's possible to apply for the Hubrecht Talent Program again! The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research. Read more in the flyer and on www.hubrecht.eu/about-us/hub...

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Reposted by Micha Müller

Ina Sonnen @sonnenlab.bsky.social · 11/03/2025

How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...

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Reposted by Micha Müller

Maximilian Madern @maxmadern.bsky.social · 03/02/2025

Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations: www.cell.com/cell/fulltex...

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Reposted by Micha Müller

Marvin Tanenbaum @marvintanenbaum.bsky.social · 03/02/2025

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

cell.com

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation

Ribosomes cooperate through transient collisions to ensure efficient translation.

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Reposted by Micha Müller

Marvin Tanenbaum @marvintanenbaum.bsky.social · 21/01/2025

Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining newly-developed single-molecule imaging approaches with in situ viral transcriptomics, we identify numerous non-canonical infection pathways. www.biorxiv.org/content/10.1...

biorxiv.org

Mapping the complete influenza A virus infection cycle through single vRNP imaging

Cell-to-cell heterogeneity is a common feature of viral infection that can generate enormous complexity, complicating understanding of infection progression and interpretation of differences between v...

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Micha Müller @michamuller.bsky.social · 21/01/2025

Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️

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Reposted by Micha Müller

Jop Kind @jopkind.bsky.social · 29/11/2024

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

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