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Michael Marty

@michaelmarty.bsky.social
852 followers 335 following 56 posts

Scientist, Mass Spec, Membrane Biochemistry, Lipids, Department of Chemistry, University of Texas at Austin, #Nanodiscs, #UniDec

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Michael Marty @michaelmarty.bsky.social · 24/09/2026
Honored to be on the 40 under 40 list from the @analyticalsci.bsky.social with a few friends @nmriley.bsky.social @mingxunwang.bsky.social @daniel-petras.bsky.social theanalyticalscientist.com/power-list/2...
theanalyticalscientist.com
The Analytical Scientist | 2026
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Michael Marty @michaelmarty.bsky.social · 17/09/2026
We are hiring for 4 new faculty positions in our department this year: chemistry.utexas.edu/prospective-.... Of particular interest is a junior analytical and senior electrochemistry. UT Austin Chemistry is a great place to be! @utaustinchemistry.bsky.social
chemistry.utexas.edu
Prospective Faculty
Info For Prospective Faculty in The Department of Chemistry at The University of Texas at Austin
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Michael Marty @michaelmarty.bsky.social · 12/08/2026
New paper from the group on design of fluorescent nanodiscs with diverse properties: doi.org/10.1021/acsc.... Congrats to Estevan and the team! All plasmids are on @addgene.bsky.social www.addgene.org/Michael_Marty/ There's also a very useful plasmid for GFP-Annexin hidden in here
doi.org
Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs
AbstractNanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSPs). They are widely used as soluble casset
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Michael Marty @michaelmarty.bsky.social · 04/08/2026
New preprint from the group describing IsoGen for isotope prediction from either FFTs or Neural Nets. Neural nets can be retrained to predict isotopes from a variety of inputs and with non-natural signatures. Check it out! Code: github.com/michaelmarty... Preprint: chemrxiv.org/doi/abs/10.2...
chemrxiv.org
Neural Network Prediction of Isotopic Distributions | ChemRxiv
Isotope distribution prediction is an important part of mass spectrometry data analysis. A variety of strategies have been developed, including brute-force polynomial methods and Fourier-transform (FT...
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Michael Marty @michaelmarty.bsky.social · 24/07/2026
Has anyone else out there that maintains open-source software packages started getting AI-generated pull requests?
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Michael Marty @michaelmarty.bsky.social · 21/07/2026
New preprint from the group: chemrxiv.org/doi/abs/10.2... This review seeks to catalog how lipidomics is used to characterize lipids bound to membrane proteins. We hope it's a useful resource for those interested in the field. It was a lot of work, but I'm excited with the result. #Lipidsky
chemrxiv.org
Measuring the Membrane Protein-Bound Lipidome | ChemRxiv
Lipids play diverse physiological roles in energy storage, signaling, and cell structure. Another less appreciated role is as allosteric modulators of membrane proteins. However, it is challenging to ...
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Reposted by Michael Marty
The University of Texas at Austin Department of Chemistry @utaustinchemistry.bsky.social · 23/06/2026
We are excited to announce that Dmitry Eremin will join our department in January 2027! @dmeremin.bsky.social chemistry.utexas.edu/news/announc...
Dmitry Eremin
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Michael Marty @michaelmarty.bsky.social · 11/06/2026
Having a fun time meeting Texas scientists at #WelchX with @thewelchfoundation.bsky.social
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Reposted by Michael Marty
Addgene @addgene.bsky.social · 17/04/2026
Thanks @michaelmarty.bsky.social for sharing! Find the plasmids here: www.addgene.org/browse/artic...
addgene.org
Addgene: Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs
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Michael Marty @michaelmarty.bsky.social · 17/04/2026
New preprint from the group where we developed fluorescent and Halo tagged nanodiscs. All plasmids are available from @addgene.bsky.social if you are interested in trying them out! www.biorxiv.org/content/10.6...
biorxiv.org
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Michael Marty @michaelmarty.bsky.social · 28/01/2026
Congrats to Christina and the team! Excited to play a small part in this nice story: www.nature.com/articles/s41...
nature.com
LetA defines a structurally distinct transporter family - Nature
The distinct architecture of the Escherichia coli membrane transporter LetA mediates lipid trafficking across the bacterial envelope in partnership with the tunnel-like complex LetB.
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Michael Marty @michaelmarty.bsky.social · 06/01/2026
Does anyone else have issues with SciENcv and MyNCBI? It feels like every other click fails. Any tips? I can sometimes get it to work by just clicking the same thing until it does it, but it's rough
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Michael Marty @michaelmarty.bsky.social · 25/11/2025
New UniDec release: github.com/michaelmarty... Lots of bug fixes, improvements, and some under the hood changes to get ready for future features. A few cool new features. More notes in thread
github.com
Release UniDec Version 8.1.0 · michaelmarty/UniDec
Version 8.1.0 UniDec. Please cite Marty et al. Anal. Chem. 2015. DOI: 10.1021/acs.analchem.5b00140 if you use UniDec in publications. Check out a video tutorial: https://www.youtube.com/watch?v=e33...
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Michael Marty @michaelmarty.bsky.social · 26/09/2025
To everyone doing cool data analysis stuff, I'd love to see some analytical chem applicants in this search! Please pass along.
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Reposted by Michael Marty
The University of Texas at Austin Department of Chemistry @utaustinchemistry.bsky.social · 26/09/2025
We invite applications for tenured faculty in any area of experimental physical chemistry. apply.interfolio.com/174607
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Michael Marty @michaelmarty.bsky.social · 06/08/2025
Assuming the voltages are correct, has anyone ever had issues running a 15 A mass spectrometer on a 30 A circuit?
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Michael Marty @michaelmarty.bsky.social · 18/07/2025
We've got a new MassSpecCodingClub module posted. The videos are linked here: github.com/michaelmarty... This module teaches how to parse FASTA files and read/write Pandas DataFrames. We explore an application of converting DDA data into an MRM transition list. Enjoy!
github.com
GitHub - michaelmarty/MassSpecCodingClub: A community dedicated to education of computer coding applied to mass spectrometry applications.
A community dedicated to education of computer coding applied to mass spectrometry applications. - GitHub - michaelmarty/MassSpecCodingClub: A community dedicated to education of computer coding a...
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Michael Marty @michaelmarty.bsky.social · 27/06/2025
Anyone know of a nitrogen pressure booster that can bring the pressure up from ~90 psi to ~110 psi?
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Michael Marty @michaelmarty.bsky.social · 12/06/2025
New review article from Hiruni and Farhana on MS of membrane proteins in the context of biotherapeutics: doi.org/10.1002/9781... (Preprint link here: doi.org/10.26434/che...)
doi.org
Membrane Proteins: Challenging Biotherapeutic Targets
Membrane proteins are about 30% of the human proteome and serve important physiological roles, including chemical transport, cell signaling, and energy transduction. Consequently, they represent abou...
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Reposted by Michael Marty
BioMassSpec @realbiomassspec.bsky.social · 10/06/2025
A Fast Neural Network for Isotopic Charge State Assignment #JACS pubs.acs.org/doi/10.1021/...
pubs.acs.org
A Fast Neural Network for Isotopic Charge State Assignment
Electrospray ionization (ESI) mass spectrometry is an essential technique for chemical analysis in a range of fields. In ESI, analytes can produce multiple charge states, which must be correctly assig...
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Michael Marty @michaelmarty.bsky.social · 10/06/2025
Excited to have this published in @jacs.acspublications.org! IsoDec is a new neural network for charge state assignment with high-resolution MS data. We test it for top-down proteomics. It's free and fast, what else could you want? pubs.acs.org/doi/full/10....
pubs.acs.org
A Fast Neural Network for Isotopic Charge State Assignment
Electrospray ionization (ESI) mass spectrometry is an essential technique for chemical analysis in a range of fields. In ESI, analytes can produce multiple charge states, which must be correctly assig...
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Michael Marty @michaelmarty.bsky.social · 14/05/2025
Two new IsoDec tutorial videos to go over top-down proteomics searching with a few different workflows, one with TopPIC and the other with MetaMorpheus @metamorpheus.bsky.social : youtu.be/OTQbplEezLQ and youtu.be/56OZJph48BU
youtu.be
IsoDec Tutorial 2: Analyzing LC-MS in the UniDec GUI with TopPIC search
YouTube video by Michael T Marty
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Reposted by Michael Marty
Mingxun Wang @mingxunwang.bsky.social · 12/05/2025
I am thrilled to share after years of work/procrastination that the MassQL manuscript is finally published in @natmethods.nature.com - "A universal language for finding mass spectrometry data patterns". This was an team effort from all co-authors that helped shape MassQL and how it could be used.
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Michael Marty @michaelmarty.bsky.social · 01/05/2025
Check out the latest tutorial video, from Marty Lab postdoc John Pavek, on how to analyze individual spectra with IsoDec, our new neural network for isotopic deconvolution: youtu.be/aOR37-j28NI
youtu.be
IsoDec Tutorial 1: Analysis of Individual Spectra
YouTube video by Michael T Marty
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Michael Marty @michaelmarty.bsky.social · 24/03/2025
Would anyone be interested in me holding a UniDec/IsoDec office hour at ASMS this year?
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Michael Marty @michaelmarty.bsky.social · 15/03/2025
Well, the USA may be getting worse, but UniDec is getting better. Check out the new version here: github.com/michaelmarty... Mostly bug fixes. I'd love some people to try it out and let me know how it works on their computers. Hopefully it fixes issues with it getting blocked by antiviruses
github.com
Release UniDec Version 8.0.1 · michaelmarty/UniDec
Version 8.0.1 UniDec. Please cite Marty et al. Anal. Chem. 2015. DOI: 10.1021/acs.analchem.5b00140 if you use UniDec in publications. Check out a video tutorial: https://www.youtube.com/watch?v=e33...
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Michael Marty @michaelmarty.bsky.social · 06/03/2025
New paper from the group! Our first with MD simulations included. Congrats to Hiruni and Farhana, who worked really hard on this! pubs.acs.org/doi/full/10....
pubs.acs.org
Alanine Scanning to Define Membrane Protein–Lipid Interaction Sites Using Native Mass Spectrometry
Lipids surrounding membrane proteins interact with different sites on the protein with varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the str...
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Michael Marty @michaelmarty.bsky.social · 21/02/2025
New preprint from the lab on IsoDec, our new neural net for isotopic charge state assignment: chemrxiv.org/engage/chemr...
chemrxiv.org
A Fast Neural Network for Isotopic Charge State Assignment
Electrospray ionization (ESI) mass spectrometry is an essential technique for chemical analysis in a range of fields. In ESI, analytes can produce multiple charge states, which must be correctly assig...
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Michael Marty @michaelmarty.bsky.social · 21/02/2025
Does anyone have recommendations for good lab moving companies?
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Michael Marty @michaelmarty.bsky.social · 20/02/2025
Very excited to share this commentary written by Chae, Daniel, and myself about navigating the postdoc experience. This started out of a discussion in a @femalesinms.bsky.social pod last year. Enjoy! pubs.acs.org/doi/10.1021/...
pubs.acs.org
Navigating the Postdoc Experience
There are many reasons to consider postdoctoral research after completing a Ph.D. For those interested in academic careers at all levels, a postdoctoral research associate (PDRA) position is often req...
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Reposted by Michael Marty
ASMS @asms.org · 26/01/2025
The first @asms.org Winter Conference in Santa Fe is in progress. An intrepid group of skiers and snow boarders took to the slopes at #SkiSantaFe for some free afternoon fun! #TeamMassSpec
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Michael Marty @michaelmarty.bsky.social · 27/12/2024
Really excited to release a beta version of UniDec 8.0! The coolest feature is a new AI-based charge assignment for isotopic resolution data. It's performing a little better than Thrash/Xtract but way faster. Try out IsoDec if you are doing top-down! github.com/michaelmarty...
github.com
Release UniDec Version 8.0.0 · michaelmarty/UniDec
Version 8.0.0 UniDec. Please cite Marty et al. Anal. Chem. 2015. DOI: 10.1021/acs.analchem.5b00140 if you use UniDec in publications. Check out a video tutorial: https://www.youtube.com/watch?v=e33...
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Michael Marty @michaelmarty.bsky.social · 19/12/2024
It’s official! The Marty Lab will be moving to Austin this summer. Looking forward to the new adventure!
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Michael Marty @michaelmarty.bsky.social · 14/10/2024
New paper from the group combining separations with CD-MS using Hadamard transform multiplexing: pubs.acs.org/doi/full/10....
pubs.acs.org
Coupling Online Size Exclusion Chromatography with Charge Detection-Mass Spectrometry Using Hadamard Transform Multiplexing
Charge detection mass spectrometry (CD-MS) is a powerful technique for the analysis of large, heterogeneous biomolecules. By directly measuring the charge states of individual ions, CD-MS can measure ...
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Reposted by Michael Marty
PastelBio @pastelbio.bsky.social · 25/09/2024
Coupling online size exclusion chromatography with charge detection-mass spectrometry using Hadamard transform multiplexing chemrxiv.org/engage/... --- #proteomics #prot-preprint
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Michael Marty @michaelmarty.bsky.social · 03/09/2024
New paper from the group describing UniChromCD for time-resolved CD-MS data, especially with fancy demultiplexing strategies! Great work Skippy and team! pubs.acs.org/doi/full/10.... As always, the software is open-source and free
pubs.acs.org
UniChromCD for Demultiplexing Time-Resolved Charge Detection-Mass Spectrometry Data
Charge detection mass spectrometry (CD-MS) enables characterization of large, heterogeneous analytes through the analysis of individual ion signals. Because hundreds to thousands of scans must be acqu...
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Reposted by Michael Marty
PastelBio @pastelbio.bsky.social · 01/07/2024
Combining Fourier Transform Ion Mobility with Charge Detection Mass Spectrometry for the Analysis of Multimeric Protein Complexes chemrxiv.org/engage/... --- #proteomics #prot-preprint
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Michael Marty @michaelmarty.bsky.social · 11/06/2024
Finally excited to share our recent paper in Anal. Chem. using mutant cycles and native MS to study lipid binding: pubs.acs.org/doi/full/10.... Congrats to Hiruni, Farhana, and Megan on their hard work! Looking forward to seeing what's coming next!
pubs.acs.org
Simultaneous Native Mass Spectrometry Analysis of Single and Double Mutants To Probe Lipid Binding to Membrane Proteins
Lipids are critical modulators of membrane protein structure and function. However, it is challenging to investigate the thermodynamics of protein–lipid interactions because lipids can simultaneously ...
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Michael Marty @michaelmarty.bsky.social · 31/05/2024
New preprint from postdoc Skippy Sanders using multiplexed Hadamard transforms injections to interface SEC with CD-MS! He'll be talking more about it at #ASMS2024 (ThOE) and our undergrad, October, will be talking about masked multiplexing with HT-SEC-CD-MS on MOE: doi.org/10.26434/che...
doi.org
Coupling online size exclusion chromatography with charge detection-mass spectrometry using Hadamard transform multiplexing
Charge detection mass spectrometry (CD-MS) is a powerful technique for the analysis of large, heterogeneous biomolecules. By directly measuring the charge states of individual ions, CD-MS can measure ...
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Michael Marty @michaelmarty.bsky.social · 15/01/2024
Latest paper from the Marty Lab. Short summary: SARS-CoV-2 E protein forms a dimer, HIV Vpu forms a range of variable oligomers, Polio VP4 never oligomerized in our hands. Congrats to the Julia and the rest of the team! pubs.acs.org/doi/full/10....
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Michael Marty @michaelmarty.bsky.social · 03/01/2024
New set of #MassSpecCodingClub modules posted: github.com/michaelmarty... Free videos to learn coding for MS applications. Take a look and let me know via the discussion what ideas you have for future projects.
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Michael Marty @michaelmarty.bsky.social · 30/12/2023
I think we found the oldest thing in our lab. A nitrogen gas cylinder says "US Army Air Forces", which means it may be more than 76 years old. Pretty cool!
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Michael Marty @michaelmarty.bsky.social · 14/11/2023
New paper with collaborators at Thermo. How do to online buffer exchange on membrane proteins in detergent micelles and nanodiscs. Enjoy! pubs.acs.org/doi/full/10....
pubs.acs.org
Online Buffer Exchange Enables Automated Membrane Protein Analysis by Native Mass Spectrometry
Membrane proteins represent the majority of clinical drug targets and are actively involved in a range of cellular processes. However, the complexity of membrane mimetics for membrane protein solubili...
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