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Michael Kugler

@michaelkugler.bsky.social
63 followers 110 following 1 posts

Postdoctoral researcher | Hopfner lab | Gene Center #StructuralBiology #CryoEM #InnateImmunity

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Reposted by Michael Kugler
Hopfner Lab @hopfnerlab.bsky.social · 24/09/2026
A new member has arrived in the institute! 🎉🔬Our new Aquilos 2 cryo-FIB has made it to our cryoEM facility! We are very excited to add this powerful technology to our structural biology toolbox. 🧊#ElectronMicroscopy @katja-lammens.bsky.social @genecenter-lmu.bsky.social @nucleate-cluster.bsky.social
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Reposted by Michael Kugler
Hopfner Lab @hopfnerlab.bsky.social · 18/09/2025
Thrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
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Reposted by Michael Kugler
cryoEM papers @cryoempapers.bsky.social · 22/11/2024
Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1
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Reposted by Michael Kugler
Hopfner Lab @hopfnerlab.bsky.social · 17/03/2025
Happy to share our latest pre-print! We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨 www.biorxiv.org/content/10.1...
biorxiv.org
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...
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Reposted by Michael Kugler
Munich RNA Club @munichrna.bsky.social · 29/01/2025
Join us in our next #MunichRNA19F! 📍 @mpibiochem.bsky.social 📅 19/02/2025 We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian. Don't miss it! 🧬😀
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Michael Kugler @michaelkugler.bsky.social · 03/12/2024
Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and Katja Lammens in @hopfnerlab.bsky.social at @genecenter-lmu.bsky.social. Now online at @naturecomms.bsky.social.
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