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Mike Clark

@michaelbclark.bsky.social

Genetics, transcriptomics, RNA and neuroscience. Lab head at the University of Melbourne, Australia. View own.

Mike Clark @michaelbclark.bsky.social · 30/03/2026

March 30th is World Bipolar Day, a global day to raise awareness of bipolar disorder and celebrate the resilience of those who live with this condition Today, the Clark Lab took part in Bipolar Australia's Bubbles for Bipolar to show our support for the more than 500k Australian’s who live with BPD

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Mike Clark @michaelbclark.bsky.social · 17/12/2025

If you're studying #RNA transcript isoforms, check out IsoVis (the Isoform Visualiser webserver). isomix.org/isovis/ Recent updates now also allow visualisation of: 1. RNA modification sites and levels 2. Peptides mapping to open reading frames in isoforms and their abundances. 🧪

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Mike Clark @michaelbclark.bsky.social · 15/12/2025

#LightOvercomesDarkness

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Mike Clark @michaelbclark.bsky.social · 26/11/2025

This project was led by the talented @jakobschuster.bsky.social in colab with @qgouil.bsky.social & @mritchieau.bsky.social As an example of the power of Matchbox, Jakob’s last tool was Restrander. A 17 line matchbox script achieved the same result as 1400 lines of C++ in Restrander!

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Mike Clark @michaelbclark.bsky.social · 26/11/2025

We’ve demonstrated Matchbox for demultiplexing long-read scRNA-seq data with 10X or SPLiT-seq barcodes; restranding RNA-seq reads; assessing CRISPR editing efficiency; and haplotyping repeat regions. Matchbox is implemented in rust and available from github.com/jakob-schust....

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Mike Clark @michaelbclark.bsky.social · 26/11/2025

Sequencing data requires read processing. Some tasks are common (trimming, de-multiplexing, filtering) & others bespoke, especially if you have non-standard read-structures. Introducing Matchbox: a fast and incredibly versatile read processor that can do all this & more 🧪 doi.org/10.1101/2025...

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Mike Clark @michaelbclark.bsky.social · 03/10/2025

Research has shown genetic risk for disease can be imparted at the isoform level, as well as the gene level. Therefore, understanding which isoforms genes express is essential to correctly determining the disease-associated isoforms and the molecular mechanisms behind disease aetiology.

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Mike Clark @michaelbclark.bsky.social · 03/10/2025

Overall we found more than 300 previously unreported RNA isoforms from 31 genes in brain. Some were highly abundant or even the dominant isoform, and we could show translation of novel RNAs into novel proteoforms, including new isoforms of the depression risk gene ITIH4 (see image).

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Mike Clark @michaelbclark.bsky.social · 12/08/2025

- Different RNA isoforms from the same gene can have different modification rates at the same m6A site. Distance to a splice site, transcript 3' end, and the CDS versus UTR status of a nucleotide all exert influence.

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