iiinova — where your digital self keeps evolving

MetaMorpheus @metamorpheus.bsky.social · 09/04/2026

those who say it cannot be done should not interrupt those doing it

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MetaMorpheus @metamorpheus.bsky.social · 06/02/2026

I like the idea of you being able to write prescriptions

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MetaMorpheus @metamorpheus.bsky.social · 08/01/2026

incidentally. no language requirement for the chemistry phd at univ of michigan, which was your original question.

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MetaMorpheus @metamorpheus.bsky.social · 07/01/2026

Min 4 semesters of German in college for bs in chemistry at purdue in the late 80s. no requirement for a ba degree.

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MetaMorpheus @metamorpheus.bsky.social · 06/01/2026

Wanna know what's better than a curved monitor? Two curved monitors, donettes, poptarts and coffee. That's what. Oh and cool new preprints. That too!

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MetaMorpheus @metamorpheus.bsky.social · 06/01/2026

Here is a list of proteins that you won't be interested in despite having spent hours in the lab collecting and processing samples not to mention thousands of dollars. See you soon for more of same.

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MetaMorpheus @metamorpheus.bsky.social · 25/11/2025

I don't mean to poke the moose. But, if we need a certain number of professors, why does it matter if they are young or old. Shouldn't it matter that the professors are good at being professors? I'm receptive to a good argument why young are better than old. But i'm a little suspicious.

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Reposted by MetaMorpheus

Phil W @pwilmarth.bsky.social · 23/11/2025

Are you curious about what steps you need to do to analyze very large multi-plex TMT datasets? This is a reanalysis of some Gygi Lab mouse liver data from 2015 and 2021 with 14.5 million MS2/MS3 scans in total. The big data needed a big discussion (kind of a long read). github.com/pwilmart/mou...

github.com

GitHub - pwilmart/mouse_liver_TMT_reanalysis: Reanalysis of large-scale TMT mouse liver studies (2015 and 2021) from the Gygi Lab.

Reanalysis of large-scale TMT mouse liver studies (2015 and 2021) from the Gygi Lab. - pwilmart/mouse_liver_TMT_reanalysis

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MetaMorpheus @metamorpheus.bsky.social · 13/10/2025

so.....short answer is follow up any search guess w/ legit targeted proteomics. was my thinking. but i'm just trying to see what true believers would say.

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MetaMorpheus @metamorpheus.bsky.social · 13/10/2025

This is all completely hypothetical. According to Chat-GPT, it is rare to find a bacterial protein in plasma outside of a distinct cause (gut performation). But for the sake of argument it offered up flagellin from e. coli. So, let's say I had a couple peptide Ids from that.

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MetaMorpheus @metamorpheus.bsky.social · 13/10/2025

metaproteomics?????? skeptical scientist here: but, let's say for argument sake you wanted to confidently identify an adventitious bacterial protein in human plasma, is there a "gold-standard" method? I assume the search result is merely the start point.

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MetaMorpheus @metamorpheus.bsky.social · 10/10/2025

I've seen a spike in major ampullate spidroins (MaSp1 and MaSp2) from a "certain lab in pittsburgh".

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Reposted by MetaMorpheus

Lukas Käll @lukaskall.bsky.social · 08/10/2025

There is a position open in our lab, within this network. Our project deals with assessing identification and quantification errors for MS-based proteomics. www.protaiomics.eu/project/dc13... Please check out all the project descriptions at the site below:

protaiomics.eu

DC13-KTH – ProtAIomics

STOCKHOLM

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MetaMorpheus @metamorpheus.bsky.social · 24/09/2025

Not bike mechanic? Aren’t you all about the tour de French fries.

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MetaMorpheus @metamorpheus.bsky.social · 24/09/2025

No one has stepped up to be our cult leader. I’d follow you anywhere. Interested?

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MetaMorpheus @metamorpheus.bsky.social · 24/09/2025

So. I want to hear about everyone’s alternate life dream. When you finally get disenfranchised, what would you do if you could do what you want?

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MetaMorpheus @metamorpheus.bsky.social · 24/09/2025

I’m thinking we should all form a colony of off-grid proteomics ex-pats (read: formerly employed) where we can all live out our dreams. We can call it Animal Farm.

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MetaMorpheus @metamorpheus.bsky.social · 17/09/2025

What a missed opportunity!!!!!!! @proteomicsnews.bsky.social Backyard Proteomics: A Case Study with the Black Widow Spider | Journal of Proteome Research pubs.acs.org/doi/full/10....

pubs.acs.org

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MetaMorpheus @metamorpheus.bsky.social · 07/08/2025

I don't know anything about the monetary side of this. 1. I do love to see more of my old #TeamMassSpec friends here 2. But, the #TeamMassSpec conversation is a pale shadow of its former self :(

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MetaMorpheus @metamorpheus.bsky.social · 06/08/2025

Referee questioned the adoption/accessibility of lc-ms to the research community. I think that's reasonable. So, realistically, how big of a problem do I need to solve to make my method worth the investment and effort? What is a thoughtful response to this critique?

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MetaMorpheus @metamorpheus.bsky.social · 04/08/2025

Maybe you could work there and develop a new biometric test that will make it even harder and take longer to get through security? Honestly, it's getting to the point that it is not worth the effort for me to buy a 100 pounds of canned tuna to save 12cent.

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MetaMorpheus @metamorpheus.bsky.social · 04/08/2025

IDK. I'm confidant that I am wrong most of the time and I don't attend CS conferences. This may be a widespread problem.

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Reposted by MetaMorpheus

PastelBio @pastelbio.bsky.social · 30/07/2025

Improved Detection of Differentially Abundant Proteins through FDR-Control of Peptide-Identity-Propagation pubs.acs.org/doi/10.... --- #proteomics #prot-paper

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MetaMorpheus @metamorpheus.bsky.social · 23/07/2025

out of curiosity, and only if you are willing, what are your preferred modes of communication?

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MetaMorpheus @metamorpheus.bsky.social · 17/07/2025

on the off chance that you are wondering..... ChatGPT put this little questionnaire together for you to peform an at-home assessment. Enjoy.

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MetaMorpheus @metamorpheus.bsky.social · 17/07/2025

Phenotype of the contemporary grant referee:

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MetaMorpheus @metamorpheus.bsky.social · 15/07/2025

referees found a similar hole in my last grant application. must be spreading.

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MetaMorpheus @metamorpheus.bsky.social · 23/06/2025

Hey Team Proteomics. New release of MetaMorpheus now natively supports Bruker .d files for DDA PASEF. Also now supporting .msalign as inputs. get your copy free now while they last: github.com/smith-chem-w...

github.com

Releases · smith-chem-wisc/MetaMorpheus

Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities - smith-chem-wisc/MetaMorpheus

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MetaMorpheus @metamorpheus.bsky.social · 18/06/2025

Good luck. You've done everything within your control. recommend managing your expectations. don't ask me how i know.

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Will Fondrie @willfondrie.com · 05/06/2025

Stop by poster ThP 289 to… calmly discuss… metadata collection and management with Anastasiya 👏 #ASMS2025

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MetaMorpheus @metamorpheus.bsky.social · 15/05/2025

That's me! Why don't you respond to my inquires?

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MetaMorpheus @metamorpheus.bsky.social · 15/05/2025

There is an individual for whom I have reviewed several papers. I am quite used to being told by them that my suggestions are beyond the scope, blah blah. Unironically I am satisfied by this non-response because of my tremendous respect for that individual. You may get a + response to your "no".

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Reposted by MetaMorpheus

Michael Marty @michaelmarty.bsky.social · 14/05/2025

Two new IsoDec tutorial videos to go over top-down proteomics searching with a few different workflows, one with TopPIC and the other with MetaMorpheus @metamorpheus.bsky.social : youtu.be/OTQbplEezLQ and youtu.be/56OZJph48BU

youtu.be

IsoDec Tutorial 2: Analyzing LC-MS in the UniDec GUI with TopPIC search

YouTube video by Michael T Marty

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MetaMorpheus @metamorpheus.bsky.social · 14/05/2025

That referee probably works for doge

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Reposted by MetaMorpheus

Chris Ashwood @cashwood.proteaglyco.com · 08/05/2025

In a 2 year period, we have had three major DIA software platforms (one open source) establish companies. The newest, Fragmatics, is now licensing MSfragger instead of the University of Michigan. www.fragmatics.com

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