α-Synuclein (αSyn) aggregation is a defining pathological feature of synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy (MSA). However, existing i...

Cell Death & Differentiation - ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection

Abstract. SET, the nuclear proto-oncogene, is primarily expressed as SETα in embryonic stem cells (ESCs). Upon pluripotency exit, a transcriptional switch

In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors rev...

Zara's Center is an after-school safe haven for AIDS orphans and vulnerable children in Bulawayo, Zimbabwe. The Center provides daily meals, academic enrichment, medical care, work training, recreatio...

Background Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset p...

Zijlmans and Stelloo et al. profiled in vivo proximal interactomes of PRC1 and PRC2 in mouse embryonic stem cells, identifying >100 proteins, including transcription factors and RNA-binding proteins. ...

Linker histone H1, the most abundant chromatin protein, condenses chromatin, modulates DNA transactions such as transcription and DNA replication/repair, and participates in differentiation, developme...