In this preprint, Melody Parker as part of her DPhil, has analysed a series of infections in a neonatal intensive care unit. At the time there was concern that this could be an outbreak; if so the ICU team would want to improve their infection control measures. Whole genome sequencing can give you the really fine-grained resolution to be able to say that these two infections likely came from the same source or, more subtly for Enterobacterales, that the plasmid carrying the AMR gene in these two different species is identical and therefore is likely to have hopped from one to the other in the hospital environment.

Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...

Nature Genetics - Genome-wide analyses identify variants associated with infertility and reproductive hormone levels but find limited polygenic overlap between reproductive hormone levels and...