iiinova — where your digital self keeps evolving

Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 09/10/2026

New in @natcomms.nature.com from Dr. Megan Baker and Dr. Lloyd Cantley: across 106 kidney biopsies, AIN concentrates CXCL9 T cell signaling in lymphoid aggregates that are rare in ATI and absent in healthy kidney, raising the possibility of new targets. medicine.yale.edu/internal-med...

medicine.yale.edu

New Study Maps Immune Pathways Driving Acute Interstitial Nephritis

In a new study published in Nature Communications, Yale researchers used advanced cell profiling techniques to obtain the most detailed view yet of how kidney

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 03/10/2026

Congratulations to Dr. Maryam Gondal, the Yale PKD Center of Excellence, and all of our speakers on a successful ADPKD Patient Symposium today, and thank you to the patients, families, and providers who joined us for a morning on everything from genetic testing to new therapies!

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Reposted by Megan Baker

Journal of Clinical Investigation @jci.org · 22/09/2026

The difference between cysts & no cysts in polycystic kidney disease: doi.org/10.1172/JCI2... Li et al. @yalenephrology.bsky.social show that upstream protein translation on the PKD1 transcript blunts Polycystin-1 expression & can be blocked to therapeutically increase expression in PKD

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 10/09/2026

CNN ranks New Haven #2 among America's best towns to visit in 2026, citing its walkability, museums, music, theater, and, of course, a century of pizza. It's also a great place to train in nephrology! If you're considering training here, we encourage you to come see for yourself!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 04/09/2026

Our first fellowship interview day of the season started off right, with 2nd year fellow Dr. Paola Gudiño giving Renal Rounds on HIV and the kidney. Tat & gp160, TGFβ-driven matrix remodeling, mesangial apoptosis, and Sidekick-1 in the glomerulus! @ubrewster.bsky.social @yaleschoolofmed.bsky.social

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Megan Baker @meganbaker.bsky.social · 27/08/2026

8/ Thank you to the patients who consented to biopsy research, the Yale Kidney Biobank, and my coauthors! @yalenephrology.bsky.social @yalemed.bsky.social

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Megan Baker @meganbaker.bsky.social · 27/08/2026

7/ Caveats matter here: the design is cross-sectional, and our ligand–receptor results are spatial co-expression, not proven signaling. What they give us is a set of testable targets — JAK-STAT inhibition, IFN-γ neutralization, complement, and the NAD+/NAMPT axis.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

6/ The regulatory brakes appear to be missing. Checkpoint-high CD8 tissue-resident memory cells were present in every reference kidney but absent from 7 of 8 AIN samples, and every patient above 50 predicted interactions/mm² lacked them entirely.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

5/ Those loops concentrate in lymphoid aggregates: 21 across 7 of 8 AIN patients, and none in reference tissue. CXCL9–CXCR3 signaling was 3.6-fold denser inside aggregates. Complement signaling was not — that stays at the tubular interface. Two distinct compartments.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

4/ The AIN-defining axis is interferon signaling. Predicted CXCL9–CXCR3 interactions were 44-fold higher in AIN than ATI, and 41% of them were CD8 T cell to CD8 T cell, meaning the chemokine network amplifies itself rather than only pulling cells toward tubules.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

3/ VCAM1+ injured proximal tubule cells are enriched 6.5-fold in AIN compared with acute tubular injury. They aren’t passive bystanders — they produce complement (C3, C4A, C4B, CFB), and C3AR1+ macrophages sit directly against them.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

2/ AIN causes 15–20% of biopsy-proven AKI, and management hasn’t moved in decades: stop the drug, try steroids, hope. Steroids fail in 20–40%. The infiltrate has been described for years, but the molecular circuits behind it haven’t.

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Megan Baker @meganbaker.bsky.social · 27/08/2026

Our study of acute interstitial nephritis is out in Nature Communications. We used imaging mass cytometry and single-cell spatial transcriptomics on 106 human kidney biopsies to ask what separates AIN from other causes of AKI at the tissue level. 🧵 www.nature.com/articles/s41...

nature.com

Spatial analysis reveals cellular microenvironments and mechanisms of inflammation and injury in acute interstitial nephritis - Nature Communications

Spatial analysis of human kidney biopsies reveals that acute interstitial nephritis differs from nonimmune kidney injury, identifying complement-producing injured tubules, T cell signaling and NAMPT a...

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 21/08/2026

1/ Excellent Renal Rounds this morning: 2nd year fellow Dr. Akshaya Ramaswami on "Malignant Hypertension and Thrombotic Microangiopathy: Can they complement each other?" A patient presents with severe HTN, AKI, and TMA. Which one caused the other? The answer changes the treatment. 🧵

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 14/08/2026

Drs. Alani and Asch at Renal Rounds: “To Include or Not Include the Kidney: Decision-Making in Simultaneous Organ Transplantation.” SLKT volumes keep climbing, but deciding who actually needs the kidney is still a challenge. Excellent discussion from the room!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 13/08/2026

How do B cells survive the hypertonic kidney in lupus nephritis? At Medical Grand Rounds, Dr. Irene Chernova took us from the γ subunit of the Na-K-ATPase to extracellular ATP signaling via P2RX4 and P2RX7. Genuinely surprising axis & terrific discussion. Excited for what's next!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 07/08/2026

Renal Rounds this morning: 2nd year fellow Dr. Erica Marnet on “Lupus Nephritis: Treatment Paradigm.” Dysregulated B cells, sustained interferon signaling & how the mechanisms map onto what we actually reach for in clinic.

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 15/07/2026

Yale Nephrology faculty gathered at Harvest Wine Bar in downtown New Haven to celebrate Dr. Marzuq Billah and Dr. Deepa Jayaram and wish them well in their next chapters! Grateful for all they've brought to our section. Best of luck in what comes next!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 10/07/2026

Summer physiology noon conferences are back, starting today with Dr. Peter Aronson! A rite of passage for generations of Yale Nephrology fellows, learning physiology from the scientists who helped discover it. And somehow there is always something new to learn! @yaleschoolofmed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 07/07/2026

First Fellows Tuesday Teaching Conference for our first years, led by Dr. Perazella giving his high yield and practical annual Poisonings and Intoxications lecture! @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 01/07/2026

Stacks of nephrology textbooks, the small blue book all our alumni still have, & Dr. Brewster's meticulous binder: it's Orientation Day for our 2026 Nephrology Fellows! Welcome to Yale, Drs. Angammana, Min, Nazir, Okoro, Ramadhar, Wortman, & Yee! @ubrewster.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 16/06/2026

Few nights mean as much to us as our fellowship graduation. Last night the Yale Nephrology fellowship gathered at the Yale Schwarzman Center to celebrate our graduating fellows and the faculty who trained them. 🎓

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 05/06/2026

Renal Rounds this morning: our 2nd-year fellows presented their QI project on pre-biopsy DDAVP. A genuine multi-cycle PDSA effort, mapping where doses got delayed or missed and building the fix into a new kidney biopsy order set. Awesome job! 👏 @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 02/06/2026

Always a highlight: Dr. Crowley’s fellows Tuesday teaching session on the role of the dialysis medical director, covering patient safety responsibilities and the CMS Conditions for Coverage that define the job. Engaging and practical as always!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 15/05/2026

First-year fellow Dr. Akshaya Ramaswami took on green nephrology at renal rounds today, walking through water conservation strategies in hemodialysis and the many ideas on the horizon for shrinking our environmental footprint! 👣🌱

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 13/05/2026

First multicenter US real-world data on terlipressin for HRS-AKI from the HRS-HARMONY consortium. Response rates and adverse events tracked the CONFIRM trial closely. Yale among 16 contributing sites, with Dr. Justin Belcher! 🔗 ⬇️ pubmed.ncbi.nlm.nih.gov/42107856/

pubmed.ncbi.nlm.nih.gov

U.S. Experience with Terlipressin in Hepatorenal Syndrome: Response, Mortality, and Transplant Outcomes - Results from the HRS Harmony Consortium - PubMed

This U.S. multicenter study provides insights into real-world use of terlipressin for HRS-AKI. Terlipressin was frequently used in patients with ACLF grade 3. Adherence to FDA labeling criteria was as...

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 07/05/2026

Photo day at Yale Nephrology. 30+ people, one staircase, and a group of fellows with serious range. 2026 section photos are in! @yalemedicine.bsky.social @yalemed.bsky.social @ubrewster.bsky.social @meganbaker.bsky.social @fperrywilson.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 24/04/2026

Renal Rounds this morning with Dr. Daniel Guevara-Pineda and colleagues from Clínica Anglo Americana in Lima, Perú on the current status and challenges of kidney transplant in Perú. Excited to be developing this new sister transplant partnership with Yale and see where it leads!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 22/04/2026

One of our fellows' favorite outpatient rotations? PD clinic. Today alongside Dr. Brewster (@ubrewster.bsky.social), Drs. Moss, Alani, and Henderson worked on manual exchanges and troubleshooting catheter and exchange hiccups -- hands-on learning at its best!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 17/04/2026

1/ Renal Rounds this morning: first-year fellow Dr. Laura Onuchic walked us through Alport syndrome, from GBM biology to the new genomics-based classification, gene therapy horizons, and post-transplant considerations! 🧵on the highlights:

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 10/04/2026

This morning at Renal Rounds, first year fellow Dr. Erica Marnet delivered a masterclass on C3 glomerulopathy - a rare but mechanistically rich complement-mediated kidney disease. Key pearls:🧵

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 01/04/2026

2nd year fellow Dr. Becky Kurian just returned from a rotation at Mulago National Referral Hospital in Uganda through the Makerere University–Yale collaboration. Grateful for this partnership and the remarkable colleagues who make experiences like hers possible. Looks like so much fun!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 27/03/2026

Excellent Renal Rounds this morning by first-year fellow Dr. Fernando Onuchic on Mesoamerican Nephropathy - a real conversation starter! 👏 Key takeaways from his presentation on this important and underrecognized topic 🧵 @ubrewster.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 26/03/2026

New pub from Drs. Larry Xu, Phylis Li, Lloyd Cantley, Jiankan Guo, Yuchu Chen, & Isabel Melchinger in Cell Death & Disease! CXCR6+ T cells drive tubular cell death during AKI→CKD: blocking CXCL16-CXCR6 axis may help slow CKD progression. @natureportfolio.nature.com www.nature.com/articles/s41...

nature.com

CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition - Cell Death & Disease

Cell Death & Disease - CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 20/03/2026

Always inspiring to hear from Dr. Will Chang at his Research in Progress talk - bringing creative approaches to kidney tissue engineering to tackle kidney disease! 🔬🧪

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 04/03/2026

Dr. @ubrewster.bsky.social delivered such an inspired Tuesday Fellow Teaching session on iron and EPO that our fellows needed a little boost of their own — and headed straight to Geronimo's afterward. Cheers to great teaching and even better company! 🍸

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 27/02/2026

Aloha and mahalo, Dr. Calvin Henderson! 🌺 Our 2nd year Hawaii-bound fellow gave his final Renal Rounds today, covering unique nephrology challenges in Hawaii, from heat-related AKI to leptospirosis to decompression sickness. Hawaiian shirt, lei and all 🌴 A first for Yale Neph!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 23/02/2026

Excellent foresight giving our fellows weighted blankets for Fellows Appreciation Month - buried under this thing, we’re all wondering, what nor’easter? ❄️ Of course, it pairs best with some very light reading from the pile of textbooks we gifted at orientation. We appreciate you!

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 20/02/2026

Congratulations to "Dr." Dr. Megan Baker (@meganbaker.bsky.social) on successfully defending her PhD through the Investigative Medicine Program yesterday! 🎉🎓 So proud of this accomplishment - Yale Nephrology showed up in full force to fill Fitkin Auditorium and cheer her on! 🥂

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 13/02/2026

2nd year fellow and rising nephrohematology expert Dr. Emily Moss presenting on sickle cell disease for her last Renal Rounds as a fellow! @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 10/02/2026

Calcium handling on the agenda for today’s fellow physiology chalk talk by 2nd year Dr. Alani! ✏️ 🩻 Complete with catered treats from Havenly downtown for Fellows Appreciation Month! @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 10/02/2026

From our International Food Day feast to a surprise visit from Heidi, Yale’s beloved retired police dog 🐾 – it’s been a pretty great couple of weeks in nephrology! Nothing warms up a cold February like great food and a visit from our four-legged friend! @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 06/02/2026

So proud of our 2nd year fellow and soon-to-be @mskcancercenter.bsky.social critical care fellow Dr. Shivankshi Berry on delivering her very last renal rounds this morning on CRRT! Great review of the primary data leading to a great discussion! @ubrewster.bsky.social @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 04/02/2026

🚨 New from the Cantley lab in @asnpublications.bsky.social! Bharathan et al. found that arginase-1+ macrophages team up with myofibroblasts to drive IGF1-dependent tubule repair after AKI - highlighting an unexpected reparative role for activated myofibroblasts. 🔗⬇️ journals.lww.com/kidney360/ab...

journals.lww.com

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 03/02/2026

February is Fellow (Extra) Appreciation Month! Kicking it off with Dr. Turner talking secondary HTN with cupcakes. Carbs and catecholamines — a winning combo. 🧁 @ubrewster.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 14/12/2025

Another wonderful Yale Nephrology holiday party last night! We love any excuse to gather this amazing group together, but this annual night at the Eli Whitney Museum is always a special one. Happy holidays to all! 🕎🎄❄️ @yalemedicine.bsky.social @yalemed.bsky.social @ubrewster.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 09/12/2025

Has been all outstanding research faculty talks since the #Match last week! Dr. @fperrywilson.bsky.social giving Yale Nephrology RIP, Dr. Whitney Besse teaching us about genetic testing and kidney disease, and Dr. Lloyd Cantley presenting at the HTI Seminar! @yalemed.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 09/12/2025

Congratulations to our Sectional Pitch Master Dr. Whitney Besse for winning 1st place at the 2025 Yale Life Science PitchFest live pitch session for her project PKD1 UORF-Blocking ASOs as Therapy for ADPKD!! So impressed, so proud!! @yaleventures.bsky.social

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Reposted by Megan Baker

Yale Nephrology @yalenephrology.bsky.social · 03/12/2025

Match Day is here! We're so excited to welcome an incredible group of future fellows to Yale Nephrology. We can't wait to have you join us in New Haven! 🎉 #FellowshipMatch2025 #Nephrology

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