A methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical halogen...

Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.

Amino acids are one of nature’s most privileged building blocks for generating molecular diversity on length-scales ranging from small molecules to proteins. While amino acid products arising from cer...