Reposted by Ioannis (Yanni) Kipouros
New paper led by postdoc @yannikipouros.bsky.social is out today in Nature! We show how metal coordination mining of AlphaFold reveals dozens of new radical halogenase families, including the promiscuous biocatalyst BtnX. #enzymes #bioinformatics #biocatalysis #secmet
www.nature.com/articles/s41...
nature.com
Targeted enzyme discovery using metal-coordination mining - Nature
A methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical halogen...