The role of fast A-nociceptors in mechanical pain and protective reflexes is unclear. This study shows that these fibers mediate rapid reflexes and contribute to pain perception in humans and mice, an...

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

Psychosis is often characterized by disturbances in the sense of self, with patients frequently misattributing self-produced sensations to external sources. While somatic hallucinations and mispercept...

Researchers analyzed gene activity in different human sensory nerve cells to predict which would respond to stimuli such as heat, cold, and pressure

The diversity of mechanical pain sensations in humans cannot be explained based on our current understanding of pain-sensing neural classes in the skin. To begin to bridge this gap, we dissected the n...

TRPV1 ion channels allow for water flow through them and their activity can be suppressed by downregulating the permeation of cations through the channels via the administration of deuterated water.