New paper from me (Kristen Harris lab at UT-Austin): doi.org/10.1371/jour... 🧪 #neurosckyence
This paper introduces our synaptopodin (Synpo) knockout rats. Synpo encodes an actin-binding protein (named for brain synapses and the kidney podocytes where it was first found).
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doi.org
Synaptopodin KO rat for assessing the dendritic spine apparatus and axonal cisternal organelle in synaptic plasticity, development, and behavior
The actin-binding protein synaptopodin (Synpo) regulates the cytoskeleton and organization of the endoplasmic reticulum, thereby amplifying intracellular Ca2+ signaling. Knockout (KO) mouse models hav...